The effects of unilateral 6-OHDA lesion in medial forebrain bundle on the motor, cognitive dysfunctions and vulnerability of different striatal interneuron types in rats

Ma, Yuxin; Zhan, Mali; Ouyang, Liang; Li, Youlan; Chen, Si; Wu, Jiajia; Chen, Jiachang; Luo, Cheng; Lei, Wanlong

doi:10.1016/j.bbr.2014.02.039

Cited by 65 publications

(44 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Based on these findings, we postulate that Calb2 may initiate PD development in the gut. Our hypothesis is supported by previous findings that Calb2 expression is reduced in neurons following 6-OHDA treatment in a PD rat model 118,119 .…”

Section: Discussionsupporting

confidence: 91%

See 1 more Smart Citation

Functional and molecular early enteric biomarkers for Parkinson’s disease in mice and men

Gries

Christmann

Schulte

et al. 2020

Preprint

View full text Add to dashboard Cite

Parkinson's disease (PD) usually has a late clinical onset. The lack of early biomarkers for the disease represents a major challenge for developing timely treatment interventions. Here, we use an -synuclein-overexpressing transgenic (Th-1-SNCA-A30P) mouse model of PD to identify appropriate candidate markers in the gut for early stages of PD before hallmark symptoms begin to manifest. A30P mice did not show alterations in gait parameters at 2 months of age, and these mice were therefore defined as pre-symptomatic A30P mice (psA30P). We discovered early functional motility changes in the gut and early molecular dysregulations in the myenteric plexus of psA30P mice by comparative protein and miRNA profiling and cell culture experiments. We found that the proteins neurofilament light chain, vesicle-associated membrane protein 2 and calbindin 2, together with the miRNAs that regulate them, are potential biomarkers of early PD that may facilitate timely treatment and/or prevention of PD in men.

show abstract

Section: Discussionsupporting

confidence: 91%

“…Moreover, Calb2 has been associated with other neurological disorders including schizophrenia and autism 119,120,121 . The density of Calb2-positive neurons is reduced in the caudate nucleus in autism.…”

Section: Discussionmentioning

confidence: 99%

Functional and molecular early enteric biomarkers for Parkinson’s disease in mice and men

Gries

Christmann

Schulte

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…The degeneration of nigrostriatal terminals is also reflected in reduced concentrations of proteins associated with dopamine production and transport (tyrosine hydroxylase and dopamine transporters [DATs]; Sun et al, ), whereas the long‐lasting impact of 6‐OHDA on proteins related to ACh is not yet clear. For instance, while Ma et al () reported a decrease in striatal choline acetyltransferase concentration following 6‐OHDA infusions, no changes could be observed by Pezzi, Checa, & Alberch (). We used the 6‐OHDA model to test the efficacy of a single intrastriatal administration of BoNT‐A.…”

Section: Introductionmentioning

confidence: 94%

“…For instance, while Ma et al (2014) reported a decrease in striatal choline acetyltransferase concentration following 6-OHDA infusions, no changes could be observed by Pezzi, Checa, & Alberch (2005). We used the 6-OHDA model to test the efficacy of a single intrastriatal administration of BoNT-A.…”

mentioning

confidence: 99%

Intrastriatal administration of botulinum neurotoxin A normalizes striatal D₂R binding and reduces striatal D₁R binding in male hemiparkinsonian rats

Wedekind

Oskamp

Lang

et al. 2017

J of Neuroscience Research

View full text Add to dashboard Cite

Cerebral administration of botulinum neurotoxin A (BoNT-A) has been shown to improve disease-specific motor behavior in a rat model of Parkinson disease (PD). Since the dopaminergic system of the basal ganglia fundamentally contributes to motor function, we investigated the impact of BoNT-A on striatal dopamine receptor expression using in vitro and in vivo imaging techniques (positron emission tomography and quantitative autoradiography, respectively). Seventeen male Wistar rats were unilaterally lesioned with 6-hydroxydopamine (6-OHDA) and assigned to two treatment groups 7 weeks later: 10 rats were treated ipsilaterally with an intrastriatal injection of 1 ng BoNT-A, while the others received vehicle (n 5 7). All animals were tested for asymmetric motor behavior (apomorphine-induced rotations and forelimb usage) and

show abstract

“…The Morris water maze task was performed on day 6 after the KA injection according to our previous study and others [14][15][16]. In brief, the rats were trained four times a day for five consecutive days, followed by the probe trial on the last day in the water maze task.…”

Section: Morris Water Maze Taskmentioning

confidence: 99%

Effects on Spatial Cognition and Nociceptive Behavior Following Peripheral Nerve Injury in Rats with Lesion of the Striatal Marginal Division Induced by Kainic Acid

Zhou

et al. 2015

Neurochem Res

Self Cite

View full text Add to dashboard Cite

Neuropathic pain and cognitive deficit are frequently comorbidity in clinical, but their underlying correlation and mechanisms remain unclear. Here, we utilized a combined rat model including kainic acid (KA) injection into bilateral striatal marginal division and chronic constriction nerve injury (CCI). PET/CT scans revealed that the SUVmax of KA rats was significantly decreased when compared to naive and saline rats. In contrast to the naive and saline rats, KA rats had longer latencies in locating the hidden platform on day 4, 5 in Morris water maze task. Thermal hyperalgesia and mechanical allodynia of KA rats were alleviated following CCI. Immunostaining results showed that substance P was markedly increased within ipsilateral spinal cord dorsal horn of KA rats after CCI, especially on the post-operative day 14. By means of real-time PCR, the up-regulation of GluR within ipsilateral spinal cord dorsal horn was observed in all KA and CCI rats. PKCγ, IL-6 and NF-κB were up-regulated in both CCI rats when compared to naive and their respective sham rats. These results suggest that cognitive impairment of rats altered the pain behaviors, and these intracellular regulators play crucial roles in the process of neuropathic pain.

show abstract

The effects of unilateral 6-OHDA lesion in medial forebrain bundle on the motor, cognitive dysfunctions and vulnerability of different striatal interneuron types in rats

Cited by 65 publications

References 34 publications

Functional and molecular early enteric biomarkers for Parkinson’s disease in mice and men

Functional and molecular early enteric biomarkers for Parkinson’s disease in mice and men

Intrastriatal administration of botulinum neurotoxin A normalizes striatal D₂R binding and reduces striatal D₁R binding in male hemiparkinsonian rats

Effects on Spatial Cognition and Nociceptive Behavior Following Peripheral Nerve Injury in Rats with Lesion of the Striatal Marginal Division Induced by Kainic Acid

Contact Info

Product

Resources

About

The effects of unilateral 6-OHDA lesion in medial forebrain bundle on the motor, cognitive dysfunctions and vulnerability of different striatal interneuron types in rats

Cited by 65 publications

References 34 publications

Functional and molecular early enteric biomarkers for Parkinson’s disease in mice and men

Functional and molecular early enteric biomarkers for Parkinson’s disease in mice and men

Intrastriatal administration of botulinum neurotoxin A normalizes striatal D2R binding and reduces striatal D1R binding in male hemiparkinsonian rats

Effects on Spatial Cognition and Nociceptive Behavior Following Peripheral Nerve Injury in Rats with Lesion of the Striatal Marginal Division Induced by Kainic Acid

Contact Info

Product

Resources

About

Intrastriatal administration of botulinum neurotoxin A normalizes striatal D₂R binding and reduces striatal D₁R binding in male hemiparkinsonian rats