The effects of type 2 diabetes mellitus on the corneal endothelium and central corneal thickness

Kim, Yoo Jin; Kim, Tae Gi

doi:10.1038/s41598-021-87896-3

Cited by 31 publications

(29 citation statements)

References 33 publications

(7 reference statements)

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“…They found that among all age groups, the subjects with T2DM had shown significantly lower endothelial cell density (ECD), hexagonality, higher CV, and thicker CCT compared to non-diabetic. This difference was more noticeable among long duration DM (more than ten years) patients & higher HbA1c (more than equal to seven percent) [33,34]. When stratified by age criteria, from 60 years groups, corneal endothelial cell findings had shown significantly alteration among DM and controls.…”

Section: Various Studies For Effect Diabetes On Corneamentioning

confidence: 89%

A Study of Corneal Thickness in Type 2 Diabetes Mellitus with and without Diabetic Retinopathy

Ramani¹

2022

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Background: It is essential to assess the corneal thickness in diabetes patient. Introduction: diabetes mellitus is a major cause of blindness throughout the worldDiabetic retinopathy is the most importance given on day to day basics studies especially for ophthalmologist studied indicators in eye. However, functional oddities have been recognised in cornea too like changes in central corneal thickness. Objectives: 1. To estimate the central corneal thickness (CCT) of type 2 diabetes mellitus patients without diabetic retinopathy age/sex matched normal people. 2. To measure central corneal thickness (CCT) of type 2 diabetes mellitus patient with diabetic retinopathy with age/ sex matched normal person. Methods: This is a hospital based case control study. Expected Results: The central corneal thickness is more in type 2 diabetes patients than non-diabetic individual.

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Section: Various Studies For Effect Diabetes On Corneamentioning

confidence: 89%

A Study of Corneal Thickness in Type 2 Diabetes Mellitus with and without Diabetic Retinopathy

Ramani¹

2022

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“…We observed apparent corneal edema and increased corneal thickness in the diabetic mice over the 6 months, which was consistent with the manifestation of corneal thickening and endothelial cell loss of diabetic patients in the clinic. 8 , 32 – 34 Further, studies have shown that microvascular complications are more common among children with type 2 diabetes at the time of presentation than among those with type 1 diabetes. 35 Mice with type 2 diabetes not only had hyperglycemia but also had increased insulin and glucagon, which may be the reason for greater vulnerability.…”

Section: Discussionmentioning

confidence: 99%

Pathogenic Role of Endoplasmic Reticulum Stress in Diabetic Corneal Endothelial Dysfunction

Chen

Zhang

Xue

et al. 2022

Invest. Ophthalmol. Vis. Sci.

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Purpose Progressive corneal edema and endothelial cell loss represent the major corneal complications observed in diabetic patients after intraocular surgery. However, the underlying pathogenesis and potential treatment remain incompletely understood. Methods We used streptozotocin-induced type 1 diabetic mice and db/db type 2 diabetic mice as diabetic animal models. These mice were treated with the endoplasmic reticulum (ER) stress agonist thapsigargin; 60-mmHg intraocular pressure (IOP) with the ER stress antagonist 4-phenylbutyric acid (4-PBA); mitochondria-targeted antioxidant SkQ1; or reactive oxygen species scavenger N -acetyl- l -cysteine (NAC). Corneal thickness and endothelial cell density were measured before and after treatment. Human corneal endothelial cells were treated with high glucose with or without 4-PBA. The expression of corneal endothelial- and ER stress–related genes was detected by western blot and immunofluorescence staining. Mitochondrial bioenergetics were measured with an Agilent Seahorse XFp Analyzer. Results In diabetic mice, the appearance of ER stress preceded morphological changes in the corneal endothelium. The persistent ER stress directly caused corneal edema and endothelial cell loss in normal mice. Pharmacological inhibition of ER stress was sufficient to mitigate corneal edema and endothelial cell loss in both diabetic mice after high IOP treatment. Mechanistically, inhibiting ER stress ameliorated the hyperglycemia-induced mitochondrial bioenergetic deficits and improved the barrier and pump functional recovery of the corneal endothelium. When compared with NAC, 4-PBA and SkQ1 exhibited better improvement of corneal edema and endothelial cell loss in diabetic mice. Conclusions Hyperglycemia-induced ER stress contributes to the dysfunction of diabetic corneal endothelium, and inhibiting ER stress may offer therapeutic potential by improving mitochondrial bioenergetics.

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“…Storr-Paulsen et al 3 Schultz et al 37 Busted et al 15 Keoleian et al 38 Olsen et al 16 Inoue et al 39 Larsson et al 17 Sudhir et al 40 McNamara et al 14 Ziadi et al 41 Roszkowska et al 18 Sonmez et al 42 Rosenberg et al 19 Wiemer et al 43 Lee et al 20 Beato et al 47 Su et al 21 Wang et al 54 Oriowo et al 22 Xiao et al 55 Modis et al 23 Wang et al 57 Ozdamar et al 24 Calvo-Maroto et al 25 Briggs et al 26 Sanchis-Gimeno et al 27 Altay et al 30 Kumar et al 44 Jeziorny et al 45 Luo et al 46 Ramm et al 48 Çolak et al 49 Hanyuda et al 50 Taşlı et al 51 Srećković et al 52 Suraida et al 53 Deák et al 56 Kim and Kim 58 CCT, central corneal thickness.…”

Section: Increase In Cct Values No Increase In Cct Valuesmentioning

confidence: 99%

“…Larsson et al 17 Storr-Paulsen et al 3 Lee et al 20 Busted et al 15 Calvo-Maroto et al 25 Olsen et al 16 Luo et al 46 Roszkowska et al 18 Srećković et al 52 Rosenberg et al 19 Kim and Kim. 58 Oriowo et al 22 Ozdamar et al 24 Briggs et al 26 Sanchis-Gimeno et al 27 Altay et al 30 Çolak et al 49 Xiao et al 55 conditions in Type-1 DM patients. Blood glucose levels were pharmacologically controlled in these patients.…”

Section: Andmentioning

confidence: 99%

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Effect of diabetes mellitus on quantitative corneal anatomy – A systemic review

Sanchis‐Gimeno

Hasrod

Calvo-Maroto

et al. 2022

Afr. vis. eye health

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Background: Corneal changes occur as a direct consequence of diabetes mellitus (DM). The central corneal thickness (CCT) is a useful parameter that provides information about the status of the metabolism of the cornea and can therefore help monitor the progression of DM.Aim: The aim of this study was to determine the impact of DM on CCT and its correlation with diabetes duration and glycated haemoglobin (HbA1c) levels.Methods: The systematic review was undertaken to answer: (1) What effect does DM have on CCT values? (2) What effect does DM duration have on CCT values? (3) What effect does HbA1c levels have on CCT values? The Web of Science was used to conduct a computerised search for articles of CCT values in DM.Results: A total of 38 articles that met the criteria for inclusion were included in this systemic review. The researchers found 27 articles that observed increased CCT values in DM patients compared with control subjects. There were six studies in which increased CCT values were related to DM duration and 12 studies in which DM duration did not alter CCT values. Also, eight studies showed that CCT values increased with glycated haemoglobin levels, and 12 studies did not observe this.Conclusion: Diabetes mellitus patients usually present with increased CCT values although there is no unanimity about the effect of DM duration and increased HbA1c levels (poor glycaemic control) in the CCT values of DM patients.

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The effects of type 2 diabetes mellitus on the corneal endothelium and central corneal thickness

Cited by 31 publications

References 33 publications

A Study of Corneal Thickness in Type 2 Diabetes Mellitus with and without Diabetic Retinopathy

A Study of Corneal Thickness in Type 2 Diabetes Mellitus with and without Diabetic Retinopathy

Pathogenic Role of Endoplasmic Reticulum Stress in Diabetic Corneal Endothelial Dysfunction

Effect of diabetes mellitus on quantitative corneal anatomy – A systemic review

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