The effects of two types of Western diet on the induction of metabolic syndrome and cardiac remodeling in obese rats

Vileigas, Danielle Fernandes; Souza, Sérgio Luiz Borges de; Corrêa, Camila Renata; Silva, Carol Cristina Vágula de Almeida; Campos, Dijon Henrique Salomé de; Padovani, Carlos Roberto; Cicogna, Antônio Carlos

doi:10.1016/j.jnutbio.2021.108625

Cited by 7 publications

(2 citation statements)

References 79 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Due to their susceptibility to oxidation, erythrocytes have been used as a cell model to investigate damage to biological membranes. Lipid peroxidation promoted by REs leads to the generation of MDA, a marker associated with a variety of diseases [28]. EBSp did not promote erythrocyte hemolysis, suggesting any toxic effects.…”

Section: Discussionmentioning

confidence: 88%

Spondias purpurea L. Bark Extract Protects against Oxidative Stress and Reduces Hypercholesterolemia in Mice Fed High-Fat Diet

Antunes

Alfredo

Cunha

et al. 2022

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

Oxidative stress plays a key role in the initiation and progression of metabolic diseases, including obesity. Preventing the accumulation of reactive oxygen species and oxidative damage to macromolecules is a beneficial strategy for reducing comorbidities associated with obesity. Fruits from the Spondias genus are known for their antioxidant activity, but they are not available year-round due to their seasonality. In this context, we investigated the antioxidant activity and identified the chemical constituents of the aqueous extract of the stem bark of Spondias purpurea L. (EBSp). Additionally, we evaluated the effect of EBSp consumption on metabolic parameters in mice with obesity induced by a high-fat diet. Chemical analyses revealed 19 annotated compounds from EBSp, including flavan-3-ols, proanthocyanidins, methoxylated coumarin, and gallic and ellagic acids, besides other phenolic compounds. In vitro, EBSp showed antioxidant activity through the scavenging of the free radicals and the protection of macromolecules against oxidative damage. Cellular assays revealed that EBSp reduced the levels of malondialdehyde produced by erythrocytes exposed to the oxidizing agent AAPH. Flow cytometry studies showed that EBSp reduced reactive oxygen species levels in human peripheral blood mononuclear cells treated with hydrogen peroxide. Obese mice treated with EBSp (400 mg.kg-1) for 60 days showed reduced levels of malondialdehyde in the heart, liver, kidneys, and nervous system. The total cholesterol levels in mice treated with EBSp reached levels similar to those after treatment with the drug simvastatin. Together, the results show that the combination of the different phenolic compounds in S. purpurea L. bark promotes antioxidant effects in vitro and in vivo, resulting in cytoprotection in the context of oxidative stress associated with obesity and a reduction in hypercholesterolemia. From a clinical perspective, the reduction in oxidative stress in obese individuals contributes to the reduction in the emergence of comorbidities associated with this metabolic syndrome.

show abstract

Section: Discussionmentioning

confidence: 88%

Spondias purpurea L. Bark Extract Protects against Oxidative Stress and Reduces Hypercholesterolemia in Mice Fed High-Fat Diet

Antunes

Alfredo

Cunha

et al. 2022

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

show abstract

“…Goodman test was used to test differences in HF features. The correlation matrix was generated using a two‐tailed Pearson's correlation test 32 . All analyses were performed using Sigma Plot 12.0 (Systat Software, Inc.), except for the correlation matrix that was carried out in GraphPad Prism 8 (GraphPad Software Inc.).…”

Section: Methodsmentioning

confidence: 99%

Effects of early exercise on cardiac function and lipid metabolism pathway in heart failure

de Souza,

Mota,

da Silva

et al. 2023

J Cellular Molecular Medi

Self Cite

View full text Add to dashboard Cite

We employed an early training exercise program, immediately after recovery from surgery, and before severe cardiac hypertrophy, to study the underlying mechanism involved with the amelioration of cardiac dysfunction in aortic stenosis (AS) rats. As ET induces angiogenesis and oxygen support, we aimed to verify the effect of exercise on myocardial lipid metabolism disturbance. Wistar rats were divided into Sham, trained Sham (ShamT), AS and trained AS (AST). The exercise consisted of 5‐week sessions of treadmill running for 16 weeks. Statistical analysis was conducted by anova or Kruskal–Wallis test and Goodman test. A global correlation between variables was also performed using a two‐tailed Pearson's correlation test. AST rats displayed a higher functional capacity and a lower cardiac remodelling and dysfunction when compared to AS, as well as the myocardial capillary rarefaction was prevented. Regarding metabolic properties, immunoblotting and enzymatic assay raised beneficial effects of exercise on fatty acid transport and oxidation pathways. The correlation assessment indicated a positive correlation between variables of angiogenesis and FA utilisation, as well as between metabolism and echocardiographic parameters. In conclusion, early exercise improves exercise tolerance and attenuates cardiac structural and functional remodelling. In parallel, exercise attenuated myocardial capillary and lipid metabolism derangement in rats with aortic stenosis‐induced heart failure.

show abstract

Biochemical and morpho-mechanical properties, and structural organization of rat tail tendon collagen in diet-induced obesity model

Van Gulick,

Saby,

Mayer

et al. 2024

International Journal of Biological Macromolecules

View full text Add to dashboard Cite

The effects of two types of Western diet on the induction of metabolic syndrome and cardiac remodeling in obese rats

Cited by 7 publications

References 79 publications

Spondias purpurea L. Bark Extract Protects against Oxidative Stress and Reduces Hypercholesterolemia in Mice Fed High-Fat Diet

Spondias purpurea L. Bark Extract Protects against Oxidative Stress and Reduces Hypercholesterolemia in Mice Fed High-Fat Diet

Effects of early exercise on cardiac function and lipid metabolism pathway in heart failure

Biochemical and morpho-mechanical properties, and structural organization of rat tail tendon collagen in diet-induced obesity model

Contact Info

Product

Resources

About