The effects of topical treatment with acidified nitrite on wound healing in normal and diabetic mice

Weller, Richard; Finnen, Michael J.

doi:10.1016/j.niox.2006.04.002

Cited by 69 publications

(53 citation statements)

References 21 publications

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“…However, as the tissues were first analysed on the fifth day after laparotomy, iNOS expression could have been high in the early stages of healing, since inflammation and tissue repair start quickly following lesion manifestation. It would be in accordance with the study realized by Finnen et al 19 that showed early healing after NO application.…”

Section: Discussionsupporting

confidence: 93%

Oral or topical administration of L-arginine changes the expression of TGF and iNOS and results in early wounds healing

et al. 2016

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Brazil. Design of the study, statistical analysis, analysis of data, manuscript writing. ABSTRACT PURPOSE:To evaluate the contribution of L-arginine oral or topical rout of administration in the surgical wound healing process.METHODS: L-arginine was orally or topically administrated to mice after a laparotomy model procedure. The wounds were analyzed to evaluate the granulation tissue by HE analysis, collagen deposition, iNOS and cytokines production by immunochemisyry on wound progress. Mice used in this model were healthy, immunosupressed or diabetic and all of them were treated with different concentration of L-arginine and rout of administration. RESULTS:Suggested that groups treated with L-arginine orally or topically improved wound repair when compared with non-treatad mice. L-arginine treatment stimulated TGF-β and restricted NO production leading to a mild Th1 response and collagen deposition in injured area, when it was orally administrated. Topical administration decreased IL-8 and CCR1 expression by wound cells but did not interfere with TNF-α and IL-10 production, ratifying the decrease of inflammatory response, the oral administration however, presented a higher iNOS and TGF-β expression then. L-arginine treatment also improved the improved the wound healing in immunosupressed or diabetic mice.CONCLUSION: L-arginine administrated orally or topically can be considered an important factor in the recuperation of tissues.

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Section: Discussionsupporting

confidence: 93%

Oral or topical administration of L-arginine changes the expression of TGF and iNOS and results in early wounds healing

et al. 2016

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“…Recently, Weller and Finnen [42] reported that the topical application of acidified nitrite (NO 2 -) cream promote wound healing in normal and diabetic mice. These authors showed that applications starting from day 0 impair wound healing while an acceleration of wound closure is observed when applications start from days 1, 2, or 4.…”

Section: Discussionmentioning

confidence: 99%

Nitric Oxide Donor Improves Healing if Applied on Inflammatory and Proliferative Phase

Amadeu

Seabra

Oliveira

et al. 2008

Journal of Surgical Research

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“…80 The same concept has been demonstrated to increase microcirculatory blood flow in Raynaud patients 81,82 and to accelerate wound healing. 83 Although the effects of acidified nitrite are typically ascribed to the generation of NO, the possibility that part of the nitrite applied is absorbed and converted into NO-related products in the tissue cannot be excluded.…”

Section: Acidified Nitritementioning

confidence: 99%

Therapeutic Uses of Inorganic Nitrite and Nitrate

2008

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Abstract-Potential carcinogenic effects, blue baby syndrome, and occasional intoxications caused by nitrite, as well as the suspected health risks related to fertilizer overuse, contributed to the negative image that inorganic nitrite and nitrate have had for decades. Recent experimental studies related to the molecular interaction between nitrite and heme proteins in blood and tissues, the potential role of nitrite in hypoxic vasodilatation, and an unexpected protective action of nitrite against ischemia/reperfusion injury, however, paint a different picture and have led to a renewed interest in the physiological and pharmacological properties of nitrite and nitrate. The range of effects reported suggests that these simple oxyanions of nitrogen have a much richer profile of biological actions than hitherto assumed, and several efforts are currently underway to investigate possible beneficial effects in the clinical arena. We provide here a brief historical account of the medical uses of nitrite and nitrate over the centuries that may serve as a basis for a careful reassessment of the health implications of their exposure and intake and may inform investigations into their therapeutic potential in the future. Key Words: cardiovascular diseases Ⅲ drugs Ⅲ history of medicine Ⅲ nitric oxide Ⅲ pharmacology T he presence of nitrite (NO 2 Ϫ ) and nitrate (NO 3 Ϫ ) in bodily fluids has been known for some time. Dietary studies carried out by Mitchell et al 1 at the beginning of the 20th century established that the amounts of nitrate excreted in the urine are higher than those ingested with the food, suggesting that the excess nitrate must be a product of endogenous biosynthesis. Later metabolic balance studies by Green et al 2,3 showed that this assumption was correct and provided unequivocal evidence for mammalian nitrate biosynthesis. Griess, 4 using his eponymous chemical test, showed that human saliva contains small quantities of nitrite, and the detection of very high levels of nitrite in the urine of a volunteer, who happened to have contracted a fever, was the first indication that endogenous production of nitric oxide (NO) is part of the immune response. Nitrite is not normally present in urine, and it was Cruickshank and Moyes 5 who realized that it originated from bacterial reduction of urinary nitrate, an observation that forms the basis of today's dipstick tests for urinary tract infection. Shortly after the discovery by Palmer et al 6 that vascular endothelial cells produce NO from L-arginine, Marletta et al 7 reported that the same pathway accounts for the production of nitrite and nitrate by activated macrophages, and countless investigators have since used nitrite and nitrate to assess NO production in basic and translational research studies. More recently, the ease with which nitrate is reduced to nitrite and nitrite is converted into NO has occasioned interest in the role of plasma nitrite in vascular smooth muscle relaxation, 8 the control of blood pressure and flow, 8 and possible therapeutic uses...

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The effects of topical treatment with acidified nitrite on wound healing in normal and diabetic mice

Cited by 69 publications

References 21 publications

Oral or topical administration of L-arginine changes the expression of TGF and iNOS and results in early wounds healing

Oral or topical administration of L-arginine changes the expression of TGF and iNOS and results in early wounds healing

Nitric Oxide Donor Improves Healing if Applied on Inflammatory and Proliferative Phase

Therapeutic Uses of Inorganic Nitrite and Nitrate

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