The Effects of Topical Agents of Fluticasone Propionate, Oxymetazoline, and 3% and 0.9% Sodium Chloride Solutions on Mucociliary Clearance in the Therapy of Acute Bacterial Rhinosinusitis In Vivo

İnanlı, Selçuk; Öztürk, Özmen; Korkmaz, Mukadder; Tutkun, Alper; Batman, Caglar

doi:10.1097/00005537-200202000-00022

Cited by 59 publications

(62 citation statements)

References 18 publications

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“…There is minimal evidence regarding the use of decongestants in adult ARS. Inanli et al 203 performed an RCT looking at this topic. The primary outcome measure in this study was saccharin transit time.…”

Section: Vd3 Ars Management: Other Treatmentsmentioning

confidence: 99%

“…Multiple studies have shown it to improve saccharin transit times in normal patients and those with ARS. 203,[206][207][208] Limited evidence also exists to suggest it improves symptoms and QoL for patients with ARS. 15,209 A number of systematic reviews and clinical guidelines on the subject of saline irrigation in ARS have been published and have found an overall benefit in symptom reduction (Table V-13).…”

Section: Vd3 Ars Management: Other Treatmentsmentioning

confidence: 99%

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International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Orlandi

Kingdom

Hwang

et al. 2016

Int Forum Allergy Rhinol

554

888

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Background:The body of knowledge regarding rhinosinusitis (RS) continues to expand, with rapid growth in number of publications, yet substantial variability in the quality of those presentations. In an effort to both consolidate and critically appraise this information, rhinologic experts from around the world have produced the International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR:RS). Methods:Evidence-based reviews with recommendations (EBRRs) were developed for scores of topics, using previously reported methodology. Where existing evidence was insufficient for an EBRR, an evidence-based review (EBR) was produced. The sections were then synthesized and the entire manuscript was then reviewed by all authors for consensus. Results:The resulting ICAR:RS document addresses multiple topics in RS, including acute RS (ARS), chronic RS (CRS) with and without nasal polyps (CRSwNP and CRSsNP), recurrent acute RS (RARS), acute exacerbation of CRS (AE-CRS), and pediatric RS. Conclusion:As a critical review of the RS literature, ICAR:RS provides a thorough review of pathophysiology and evidence-based recommendations for medical and surgical treatment. It also demonstrates the significant gaps in our understanding of the pathophysiology and optimal management of RS. Too o en the foundation upon which these recommendations are based is comprised of lowerlevel evidence. It is our hope that this summary of the evidence in RS will point out where additional research efforts may be directed. C 2016 ARS-AAOA, LLC. Key Words:rhinosinusitis; chronic rhinosinusitis; acute rhinosinusitis; recurrent acute rhinosinusitis; evidence-based medicine; systematic review; endoscopic sinus surgery List of Abbreviations Used

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Section: Vd3 Ars Management: Other Treatmentsmentioning

confidence: 99%

Section: Vd3 Ars Management: Other Treatmentsmentioning

confidence: 99%

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Orlandi

Kingdom

Hwang

et al. 2016

Int Forum Allergy Rhinol

554

888

View full text Add to dashboard Cite

show abstract

“…İnanlı et al observed that fluticasone propionate administered topically for 3 weeks caused no improvement in MC in patients with acute sinusitis [5]. Similarly, Braat et al reported no decrease in ciliary cells in mucosal specimens taken from the anterior part of the concha and no statistically significant difference in MC values following 6-week administration of fluticasone propionate in patients with allergic rhinitis [9].…”

Section: Discussionmentioning

confidence: 99%

“…They also emphasized that care was required during the use of topical nasal decongestants [4]. İnanlı et al reported prolongation of MCT in patients with acute sinusitis, but observed that oxymetazoline significantly shortened MCT [5]. Van de Donk et al reported that oxymetazoline and xylometazoline reduced the ciliary beat frequency in the mucosa of the sphenoid sinus but did not alter MCT [6].…”

Section: Discussionmentioning

confidence: 99%

“…They also reported that it did this by altering the structural characteristics of mucus, rather than increasing the ciliary beat rate [13]. One study that used the saccharin test in patients with acute sinusitis compared pretreatment MC values with those after 3 weeks of treatment and reported that isotonic saline solution had no effect on nasal MC, but that hypertonic saline (3%) significantly shortened MCT [5].…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of the effects on nasal mucociliary clearance of various nasal solutions applied topically in patients with sinusitis

Yasar¹,

Sutbeyaz²,

Sakat³

et al. 2017

Med-Science

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Mucociliary clearance (MC) is one of the main defense mechanisms of the nasal respiratory mucosa. The purpose of this study was to determine changes occurring nasal MC in patients with sinusitis, and how medical treatment affects changes in MC, and to identify an appropriate topical solution with positive effects on MC for use in the treatment of sinusitis by examining the effects of various topical solutions on MC. 60 patients diagnosed with rhinosinusitis at the ear, nose and throat clinic were included in this prospective study. Patients were randomly assigned into groups. Group 1 (n:10) received no topical treatment. Group 2 (n:10) was administered with fluticasone propionate, Group 3 (n:10) received mometasone furoate and Group 4 (n:10) received oxymetazoline. Group 5 (n:10) received isotonic sea water for nasal irrigation, while Group 6 (n:10) received isotonic Ringer's solution for nasal irrigation. Group 7 represented the control group (non-sinusitis). The saccharin test was used to determine nasal mucociliary clearance times. The saccharin test was performed before and on the 2nd week of treatment in all groups. Basal MCT and 2nd week MCT values were compared in all groups. When measurements performed 20 min and 14 days after administration of topical agents were compared with basal values, mean MCT values at 20 min. and 14 days were shorter in all groups compared to mean basal MCT values. However, the difference between 20-min, 14th day and basal MCT values was only statistically significant in the oxymetazoline and isotonic Ringer's solution groups (p<0.05). We think that oxymetazoline and isotonic Ringer's solution can be used as supportive therapy in the treatment of sinusitis since these produce a significant shortening of MCT.

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A 51-Year-Old Woman With Acute Onset of Facial Pressure, Rhinorrhea, and Tooth Pain

Hwang

2009

JAMA

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The Effects of Topical Agents of Fluticasone Propionate, Oxymetazoline, and 3% and 0.9% Sodium Chloride Solutions on Mucociliary Clearance in the Therapy of Acute Bacterial Rhinosinusitis In Vivo

Cited by 59 publications

References 18 publications

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Evaluation of the effects on nasal mucociliary clearance of various nasal solutions applied topically in patients with sinusitis

A 51-Year-Old Woman With Acute Onset of Facial Pressure, Rhinorrhea, and Tooth Pain

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