The effects of tobacco smoking and rheumatoid factor seropositivity on disease activity and joint damage in early rheumatoid arthritis

Manfredsdottir, Valdis; Vikingsdottir, T.; Jónsson, Þorbjörn; Geirsson, Árni Jón; Kjartansson, Ólafur; Heimisdóttir, María; Sigurðardóttir, Sigrún; Valdimarsson, H.; Vikingsson, Arnor

doi:10.1093/rheumatology/kei240

Cited by 136 publications

(79 citation statements)

References 34 publications

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“…Smokers are more likely to have citrullinated proteins in lung lavage [19], and they have increased rheumatoid arthritis disease activity [20]. As reported by other investigators, in our cohort, smoking was associated with a UIP pattern on HRCT.…”

Section: Discussionsupporting

confidence: 79%

Predictors of mortality in rheumatoid arthritis-associated interstitial lung disease

et al. 2015

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Interstitial lung disease (ILD) is a common pulmonary manifestation of rheumatoid arthritis. There is lack of clarity around predictors of mortality and disease behaviour over time in these patients.We identified rheumatoid arthritis-related interstitial lung disease (RA-ILD) patients evaluated at National Jewish Health (Denver, CO, USA) from 1995 to 2013 whose baseline high-resolution computed tomography (HRCT) scans showed either a nonspecific interstitial pneumonia (NSIP) or a "definite" or "possible" usual interstitial pneumonia (UIP) pattern. We used univariate, multivariate and longitudinal analytical methods to identify clinical predictors of mortality and to model disease behaviour over time.The cohort included 137 subjects; 108 had UIP on HRCT (RA-UIP) and 29 had NSIP on HRCT (RA-NSIP). Those with RA-UIP had a shorter survival time than those with RA-NSIP (log rank p=0.02). In a model controlling for age, sex, smoking and HRCT pattern, a lower baseline % predicted forced vital capacity (FVC % pred) (HR 1.46; p<0.0001) and a 10% decline in FVC % pred from baseline to any time during follow up (HR 2.57; p<0.0001) were independently associated with an increased risk of death.Data from this study suggest that in RA-ILD, disease progression and survival differ between subgroups defined by HRCT pattern; however, when controlling for potentially influential variables, pulmonary physiology, but not HRCT pattern, independently predicts mortality. @ERSpublications In rheumatoid-arthritis associated interstitial lung disease, physiology, and not HRCT pattern, predicts mortality

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Section: Discussionsupporting

confidence: 79%

Predictors of mortality in rheumatoid arthritis-associated interstitial lung disease

et al. 2015

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“…A combination of genetic predisposition, immunological deregulation and environmental factors contribute to its pathogenesis [1]. The most recognized environmental risk factor for the development and severity of RA is cigarette smoking [2][3][4]. RA synovium is characterized by synovial hyperplasia and infiltration of inflammatory cells together with high production of proinflammatory cytokines such as tumor necrosis alpha (TNFα) [5].…”

Section: Introductionmentioning

confidence: 99%

Regulation and function of SIRT1 in rheumatoid arthritis synovial fibroblasts

et al. 2015

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Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation and destruction of synovial joints. The function of sirtuin (SIRT)1 in RA is inconclusive. In human synovial cells, SIRT1 was shown to promote cytokine production and apoptosis resistance. However, deletion of SIRT1 aggravated inflammatory arthritis in mice and increased production of pro-inflammatory cytokines in murine macrophages. In the current study, we investigated the regulation, expression, and function of SIRT1 in RA, in particular its role in adhesion and proliferation of human RA synovial fibroblasts (RASF). We found that expression of SIRT1 was increased in vivo in synovial tissues of RA smokers and in vitro by stimulation of RASF with TNF, but decreased upon treatment with cigarette smoke extract. Synovial tissues of RA smokers showed higher leukocytic infiltration that positively correlated with enhanced levels of SIRT1. Global transcriptome analysis revealed that SIRT1 modulates expression of genes involved in the regulation of inflammatory response and cell adhesion. In functional studies, silencing of SIRT1 reduced proliferation and leukocytic adhesion to RASF but showed inconsistent results in the regulation of adhesion to plastic. In conclusion, SIRT1 modulates the proliferative and potentially also adhesive properties of RASF and can therefore promote progression of RA. KEY MESSAGES: SIRT1 is upregulated by TNF but decreased upon CSE treatment of RASF. Upregulation of SIRT1 in RA smokers correlates with increased leukocytic infiltration. SIRT1 modulates expression of genes regulating cell adhesion and inflammation. SIRT1 regulates proliferation of RASF. AbstractRheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation and destruction of synovial joints. The function of sirtuin (SIRT)1 in RA is inconclusive. In human synovial cells SIRT1 was shown to promote cytokine production and apoptosis resistance. However, deletion of SIRT1 aggravated inflammatory arthritis in mice and increased production of pro-inflammatory cytokines in murine macrophages. In the current study we investigated the regulation, expression and function of SIRT1 in RA, in particular its role in adhesion and proliferation of human RA synovial fibroblasts (RASF). We found that expression of SIRT1 was increased in vivo in synovial tissues of RA smokers and in vitro by stimulation of RASF with TNFα, but decreased upon treatment with cigarette smoke extract.Synovial tissues of RA smokers showed higher leukocytic infiltration that positively correlated with enhanced levels of SIRT1. Global transcriptome analysis revealed that SIRT1modulates expression of genes involved in the regulation of inflammatory response and cell adhesion. In functional studies, silencing of SIRT1 reduced proliferation and leukocytic adhesion to RASF, but showed inconsistent results in the regulation of adhesion to plastic. In conclusion, SIRT1 modulates the proliferative and potentially also adhesive properties of RASF and can t...

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“…Manfredsdottir et al 44 found gradient of increase in disease activity was observed from never smokers to former smokers to current smokers defined by number of swollen joints (SJC), tender joints (TJC) and visual analogue scale for pain, while Vesperini V et al 45 foundsmoking status had no significant effect on disease activity and disability but did reduce 1-year radiographic disease progression, this due to difference in number of smoker and non smoker in that study the number of smoker was 138 and 335 was non smoker while in our study the number of smoker was 22 while non smoker was 78.…”

Section: Discussionmentioning

confidence: 99%

Romatoid Artritte Hastalık Aktivitesi ile Anti-CCP İlişkisi

Merza¹,

Tofiq²,

Radhi³

et al. 2014

Cukurova Medical Journal

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Purpose: To determine the value of Anti-CCP as predictor for disease activity in rheumatoid arthritis assessed by DAS-28, and to find the effect of smoking on disease activity in rheumatoid arthritis. Materials and Methods: One hundred patients with rheumatoid arthritis involved in this study, consisted of 88 female and 12 male who fulfilled the 2010 ACR-EULAR classification criteria for rheumatoid arthritis attending the rheumatology department in general hospital, or attended the center of rheumatology and rehabilitation in sulaimani city, for 6 months ( from October, 2012 to March, 2013). Thorough Demographic information of patients was recorded through history of age, sex, and history of smoking, disease duration, physical evaluation according to DAS-28. and serological test for RF and Anti-CCP. Results: There was highly significant association between DAS-28 and Anti-CCP value (p =0.0001). there was no significant correlation between DAS-28 and RF (p= 0.252),According to smoking there was highly significant association between smoking with Anti-CCP value and DAS-28 (p=0.003-0.0001) respectively while there was no significant association between smoking and RF(p=0.15). Conclusion: A highly significant correlation was found between Anti-CCP value and disease activity in rheumatoid arthritis, smoker patients had higher value of Anti-CCP compared to non-smoker patients. Smokers demonstrated a more active and severe disease activity compared to non-smokers.

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The effects of tobacco smoking and rheumatoid factor seropositivity on disease activity and joint damage in early rheumatoid arthritis

Abstract: Tobacco smoking has an adverse effect on patients with early RA and this is possibly immunologically mediated. IgM RF does not predict poorer prognosis in RA unless it is associated with a concomitant elevation of IgA RF.

Cited by 136 publications

References 34 publications

Predictors of mortality in rheumatoid arthritis-associated interstitial lung disease

Predictors of mortality in rheumatoid arthritis-associated interstitial lung disease

Regulation and function of SIRT1 in rheumatoid arthritis synovial fibroblasts

Romatoid Artritte Hastalık Aktivitesi ile Anti-CCP İlişkisi

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