The effects of TNF-α inhibitors on carbon tetrachloride-induced nephrotoxicity

Özdemir, Ali; Tümkaya, Levent; Kalcan, Süleyman; Uyan, Mikail; Karakaya, Ahmet; Demiral, Gökhan; Samanci, Tugba Celik; Mercantepe, Tolga; Cüre, Medine Cumhur; Cüre, Erkan

doi:10.1080/10641963.2021.2018600

Cited by 6 publications

(1 citation statement)

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“…CCl 4 has been known for many years as a potent hepatotoxic agent (Ammar et al, 2022), and its threshold limit value is 5 ppm (Dhanasekaran and Ganapathy, 2011); this solvent can increase the level of liver enzymes and lead to liver necrosis in humans and animals (Abu et al, 2022; Okoro et al, 2022; Davis, 1934); despite the restrictions on the application of this toxic solvent, it is still used in various industries for various purposes (Ozdemir et al, 2022). It should be noted that workers in industries, in addition to exposure to this solvent, are also exposed to other physical risk factors such as lifting heavy loads, inappropriate ergonomic conditions and loud noise (Said et al, 2022; Onofrejova et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

The effect of subacute co-exposure to carbon tetrachloride and diclofenac on the liver of male wistar rats

et al. 2023

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Carbon tetrachloride (CCl4) is a potent liver toxin. Diclofenac (Dic), leading adverse effects on the liver, is used among the employees of the industries that use CCl4. The increased use of CCl4 and Dic in industrial workers has prompted us to investigate their synergistic effect on the liver using male Wistar rats as a model. Male Wistar rats were divided into seven groups ( n = 6), and the exposure was by intraperitoneal injection for 14 days as follows. Group 1: Control, 2: Olive oil, 3: CCl4 (0.8 mL/kg/day (3 times per week)), 4: Normal saline, 5: Dic (1.5 mg/kg/day per day), 6: Olive oil with normal saline, 7: CCl4 (0.8 mL/kg/day (3 times per week)) and Dic (1.5 mg/kg/day daily). At the end of day 14, the heart blood was collected to measure the liver enzymes, alanine-aminotransferase (ALT), aspartate-aminotransferase (AST), blood alkaline phosphatase (ALP), albumin (ALB), direct bilirubin, and total bilirubin. A pathologist examined the liver tissue. Prism software was used to analyze data using ANOVA and Tukey statistical tests. ALT, AST, ALP, and Total Bilirubin enzymes were increased significantly in the co-administered CCl4 and Dic group, while the ALB levels decreased ( p < 0.05). The histological findings reported liver necrosis, focal hemorrhage, adipose tissue change, and lymphocytic portal hepatitis. In conclusion, using Dic while exposed to CCl4 may exacerbate hepatotoxicity in rats. Therefore, it is suggested that more severe restrictions and safety regulations be placed on using CCl4 in the industry, and caution is advised to these industry workers to use Diclofenac.

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