The effects of time-restricted eating on sleep, cognitive decline, and Alzheimer's disease

Ezzati, Armin; Pak, Victoria M.

doi:10.1016/j.exger.2022.112033

Cited by 15 publications

(8 citation statements)

References 57 publications

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“…Increasing evidence suggests that neuroinflammation involves in the pathogenesis of AD along with classic pathological features such as misfolded and aggregated proteins, like Aβ and p-Tau ( 46 ). The increased levels of IL-1β, IL-6, and TNF-α were also found in the brain tissue of AD mice ( 47 ) and AD patients ( 48 ). On the contrary, anti-inflammatory factors, such as Il-4, IL-5, IL-10, and G-CSF, can inhibit central nervous system inflammation and have neuroprotective effects.…”

Section: Discussionmentioning

confidence: 89%

Qi-fu-yin attenuated cognitive disorders in 5xFAD mice of Alzheimer's disease animal model by regulating immunity

Yang

et al. 2023

Front. Neurol.

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IntroductionCognitive impairment is the main symptom of Alzheimer's disease (AD). Accumulating evidence implicate that immunity plays an important role in AD. Here, we investigated the effect of Qi-fu-yin (QFY) on cognitive impairment and cytokine secretion of 5xFAD mice.MethodsWe used 2.5-month-old 5xFAD transgenic mice for behavioral tests to observe the changes in cognitive function after QFY treatment. After the behavioral experiment, the whole brain, cortex and plasma of each mouse were collected for soluble Aβ analysis, immunohistochemical experiment and cytokine analysis.ResultsHere we found that the treatment of QFY ameliorated the ability of object recognition, passive avoidance responses and the ability of spatial learning and memory in 5xFAD mice. The deposits of β1 − 42 and Aβ1 − 40 were alleviated and the ration of Aβ1 − 42/Aβ1 − 40 was decrease in the plasma and brain of 5xFAD mice administrated with QFY. The administration of QFY promoted the secretion of anti-inflammatory cytokines, IL-5, IL-10 and G-CSF, and reduced the content of proinflammatory cytokines IFN-γ in plasma of 5xFAD mice. Notably, we found that the treatment of QFY decreased the concentration of CCL11 in the brain and plasma of 5xFAD mice.ConclusionThis suggested that QFY improved cognition and reduced Aβ deposits in 5xFAD mice by regulating abnormal immunity in 5xFAD mice. QFY may be as a potential therapeutic agent for AD.

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Section: Discussionmentioning

confidence: 89%

Qi-fu-yin attenuated cognitive disorders in 5xFAD mice of Alzheimer's disease animal model by regulating immunity

Yang

et al. 2023

Front. Neurol.

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“…Consistent with these findings, a review study has highlighted the potential of IFA in reducing depression scores within the general population, albeit without significant effects on anxiety or mood ( Fernández-Rodríguez et al, 2022 ). In another review study, preliminary indications propose that TRE exhibits potential for eliciting neuroprotective effects on cognitive function and mitigating neuroinflammatory markers linked to Alzheimer's disease in human subjects ( Ezzati and Pak, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

Effect of time-restricted eating and intermittent fasting on cognitive function and mental health in older adults: A systematic review

Sharifi,

Rostami,

Babaei Khorzoughi

et al. 2024

Preventive Medicine Reports

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“…The Pittsburgh Sleep Quality Index (PSQI) will be used to assess the sleep quality of the participants in the last month before and after the intervention. Sleep disturbances are common in people with MCI and may accelerate MCI progression ( 47 ). The PSQI provides a global sleep quality score based on seven components (sleep quality, latency, duration, efficiency, disturbance, use of sleep medication and daytime dysfunction).…”

Section: Design and Methodsmentioning

confidence: 99%

Clinical observation and mechanism of acupuncture on amnestic mild cognitive impairment based on the gut-brain axis: study protocol for a randomized controlled trial

et al. 2023

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BackgroundAmnestic mild cognitive impairment (aMCI) is a pre-dementia condition associated with declined cognitive function dominated by memory impairment. The occurrence of aMCI is associated with the gut-brain axis. Previous studies have shown cognitive improvements in MCI after acupuncture treatment. This study evaluates whether acupuncture can produce a therapeutic effect in patients with aMCI by modulating the gut-brain axis.Methods and designThis is a prospective, parallel, multicenter randomized controlled trial. A total of 40 patients with aMCI will be randomly assigned to an acupuncture group (AG) or a waiting-list group (WG), participants in both groups will receive health education on improving cognitive function at each visit, and acupuncture will be conducted twice a week for 12 weeks in the AG. Another 20 matched healthy volunteers will be enrolled as normal control. The primary outcome will be the change in Alzheimer’s Disease Assessment Scale-cognitive scale score before and after treatment. Additionally, functional magnetic resonance imaging data, faeces, and blood will be collected from each participant to characterize the brain function, gut microbiota, and inflammatory cytokines, respectively. The differences between patients with aMCI and healthy participants, and the changes in the AG and WG groups before and after treatment will be observed. Ultimately, the correlation among brain function, gut microbiota, inflammatory cytokines, and clinical efficacy evaluation in patients with aMCI will be analyzed.DiscussionThis study will identify the efficacy and provide preliminary data on the possible mechanism of acupuncture in treating aMCI. Furthermore, it will also identify biomarkers of the gut microbiota, inflammatory cytokines, and brain function correlated with therapeutic effects. The results of this study will be published in peer-reviewed journals.Clinical trial registrationhttp://www.chictr.org.cn, identifier ChiCTR2200062084.

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The effects of time-restricted eating on sleep, cognitive decline, and Alzheimer's disease

Cited by 15 publications

References 57 publications

Qi-fu-yin attenuated cognitive disorders in 5xFAD mice of Alzheimer's disease animal model by regulating immunity

Qi-fu-yin attenuated cognitive disorders in 5xFAD mice of Alzheimer's disease animal model by regulating immunity

Effect of time-restricted eating and intermittent fasting on cognitive function and mental health in older adults: A systematic review

Clinical observation and mechanism of acupuncture on amnestic mild cognitive impairment based on the gut-brain axis: study protocol for a randomized controlled trial

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