The effects of thromboxane receptor antagonists on oestrogen‐induced uterotrophic responses in the spontaneously hypertensive rat

Kerr, Mary; Marshall, Kay; Senior, Judith

doi:10.1111/j.1476-5381.1991.tb09794.x

Cited by 2 publications

(2 citation statements)

References 19 publications

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“…The correlation between the early stimulation of PLA2 activity and the proliferation of oviduct cells is discussed. Leukotrienes also have been implicated in the preimplantation period (5) and a supportive role for thromboxane in estradiol-induced uterine growth has been proposed in the rat (6). The arachidonic acid released is not stored within the cell but is either re-esterified into lipid stores or converted into bioactive substances such as prostaglandins, thromboxanes and leukotrienes (2).…”

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confidence: 99%

Regulation of quail oviduct phospholipase A2 activity by estradiol

Chanal²,

Felouati³

et al. 1994

European Journal of Endocrinology

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The phospholipase A2 (PLA2) activity was measured in the oviduct of immature and estradiol benzoate (EB)-treated quails. The pH profiles demonstrate the presence of two PLA2 isoforms in the avian oviduct: a neutral isoform, optimally active at pH 7-7.5 and calcium independent, responsible for most of the hydrolytic activity in the immature oviduct and poorly stimulated by estradiol; and an alkaline isoform, optimally active at pH 8-9.5 and calcium dependent, with little activity in the immature tissue but markedly stimulated by EB. After EB injection, PLA2 activation occurs at first during the prereplicative period of oviduct cells (+172% at 6 h), it is dose dependent from 0.01 to 1 mg/kg EB and can be prevented by cycloheximide together with ornithine decarboxylase activation. Moreover, estradiol was inactive on cell-free extracts of immature oviducts. These results suggest that EB increases PLA2 activity through gene activation and de novo protein synthesis. The correlation between the early stimulation of PLA2 activity and the proliferation of oviduct cells is discussed.

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confidence: 99%

Regulation of quail oviduct phospholipase A2 activity by estradiol

Chanal²,

Felouati³

et al. 1994

European Journal of Endocrinology

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“…These lipid compounds, which include prostaglandins, leukotrienes and also plateletactivating factor (PAF), play many physiological roles in reproduction. They are considered to be important mediators of implantation and decidualization (see [8] for a review) and have also been implicated together with thromboxane [9], non-esterified fatty acids [10], and phosphatidic acid (PA) and lysophosphatidic acids [11,12] in the proliferation of several cell types. PLA2 itself is known to be involved in the mitogenic signal triggered by epidermal growth factor [13].…”

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confidence: 99%

Oestradiol-induced changes in the composition of phospholipid classes of quail oviduct: specific replacement of arachidonic acid by docosahexaenoic acid in alkenylacyl-glycerophosphoethanolamine

Felouati

Pageaux

Fayard

et al. 1994

Biochemical Journal

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The phospholipid composition and the molecular species of the major subclasses of ethanolamine and choline glycerophospholipids were determined during the natural or oestradiol-induced development of the quail oviduct. The phospholipid concentration increased significantly during oviduct development, and the proportion of ethanolamine glycerophospholipids (EPL) remained constant while that of choline glycerophospholipids increased. The immature oviduct contained the majority of its endogenous arachidonic acid mass (71%) in EPL, mainly in alkenylacyl-glycerophosphoethanolamine (alkenylacyl-GPE) (49% of the total). Oestrogen treatment induced the depletion of 20:4,n-6 specifically from this pool, which indicates the biological importance of 20:4,n-6 molecular species in alkenylacyl-GPE as substrates for the oviduct phospholipases activated by oestradiol, and suggests that this EPL subclass is involved in the oestrogen-induced cell proliferation. Another striking result was the marked increase in 22:6,n-3 EPL molecular species following the oestradiol treatment and more particularly the strict substitution of 20:4,n-6 by 22:6,n-3 in alkenylacyl-GPE. We speculate that alkenylacyl-GPE molecular species containing 22:6,n-3 may participate in the arrest of oestrogen-induced proliferation.

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The effects of thromboxane receptor antagonists on oestrogen‐induced uterotrophic responses in the spontaneously hypertensive rat

Cited by 2 publications

References 19 publications

Regulation of quail oviduct phospholipase A2 activity by estradiol

Regulation of quail oviduct phospholipase A2 activity by estradiol

Oestradiol-induced changes in the composition of phospholipid classes of quail oviduct: specific replacement of arachidonic acid by docosahexaenoic acid in alkenylacyl-glycerophosphoethanolamine

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