The effects of the second generation antipsychotics and a typical neuroleptic on collagen-induced platelet aggregation<i>in vitro</i>

Dietrich‐Muszalska, Anna; Rabe‐Jabłońska, Jolanta; Olas, Beata

doi:10.3109/15622970903144020

Cited by 14 publications

(3 citation statements)

References 36 publications

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“…The occlusion/occlusion-like syndrome conceptual background as a large multicausal class effect, peripheral and central was realized only quite recently [ 1 , 2 , 3 , 4 , 5 , 6 , 7 ]. Here, there was a general cytoprotective endothelial threat (i.e., a disturbed dopamine system as a long-lasting essential pitfall in cytoprotection maintenance [ 30 , 31 , 32 , 33 , 34 , 35 ], endothelium lesions, and thrombosis induced by neuroleptics [ 36 , 37 , 38 , 39 , 40 , 41 ], domperidone [ 42 ], and amphetamine [ 43 , 44 , 45 ]). This accorded a major challenge of multicausal pathology (i.e., major vessel occlusion [ 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 ] peripherally and centrally and similar noxious procedures [ 19 , 20 , 21 , 22 , 23 , 24 ] severely affecting endothelium function).…”

Section: Introductionmentioning

confidence: 99%

Innate Vascular Failure by Application of Neuroleptics, Amphetamine, and Domperidone Rapidly Induced Severe Occlusion/Occlusion-like Syndromes in Rats and Stable Gastric Pentadecapeptide BPC 157 as Therapy

et al. 2023

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Even before behavioral disturbances, neuroleptics, amphetamine, and domperidone application rapidly emerged severe occlusion/occlusion-like syndrome, shared innate vascular and multiorgan failure in rats, comparable to occlusion/occlusion-like syndrome described with vessel(s) occlusion or similar noxious procedures application. As therapy, i.e., activation of the collateral pathways, “bypassing key” (activated azygos vein pathway, direct blood flow delivery), the stable gastric pentadecapeptide BPC 157 is a novel solution. Recently, BPC 157 therapy particularly counteracted neuroleptic- or L-NAME-induced catalepsy, lithium intoxication, and schizophrenia positive and negative symptoms (amphetamine/methamphetamine/apomorphine/ketamine). In rats with complete calvariectomy, medication (BPC 157 10 µg/kg, 10 ng/kg ip or ig) was given 5 min after distinctive dopamine agents (mg/kg ip) (haloperidol (5), fluphenazine (5), clozapine (10), risperidone (5), olanzapine (10), quetiapine (10), or aripiprazole (10), domperidone (25), amphetamine (10), and combined amphetamine and haloperidol) and assessed at 15 min thereafter. All neuroleptic-, domperidone-, and amphetamine-induced comparable vascular and multiorgan failure severe syndrome was alleviated with BPC 157 therapy as before major vessel(s) occlusion or other similar noxious procedures. Specifically, all severe lesions in the brain (i.e., immediate swelling, hemorrhage), heart (i.e., congestion, arrhythmias), and lung (i.e., congestion, hemorrhage), as well as congestion in the liver, kidney, and gastrointestinal (stomach) tract, were resolved. Intracranial (superior sagittal sinus), portal, and caval hypertension and aortal hypotension were attenuated or eliminated. BPC 157 therapy almost annihilated arterial and venous thrombosis, peripherally and centrally. Thus, rapidly acting Virchow triad circumstances that occur as dopamine central/peripheral antagonists and agonist essential class-points, fully reversed by BPC 157 therapy, might be overwhelming for both neuroleptics and amphetamine.

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Section: Introductionmentioning

confidence: 99%

Innate Vascular Failure by Application of Neuroleptics, Amphetamine, and Domperidone Rapidly Induced Severe Occlusion/Occlusion-like Syndromes in Rats and Stable Gastric Pentadecapeptide BPC 157 as Therapy

et al. 2023

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“…We test the effect of antipsychotics on ADP and collagen as widely used platelet agonists, that has been previously tested with antipsychotics with controversial results [10][11][12][13]. No significant effect of any antipsychotics (at high concentration) used on platelet aggregation induced by ADP or collagen was observed, this result was expected as no affinity of antipsychotics for ADP purinergic receptors or collagen platelet receptors was shown previously.…”

Section: Link Between Platelets 5-ht Cardiovascular Disorders and Amentioning

confidence: 81%

“…Several antipsychotic drugs that antagonize 5-HT 2A receptor such as clozapine, risperidone and olanzapine have demonstrated some inhibitory effects on platelet aggregation induced by platelet agonists such as collagen, adenosine diphosphate (ADP) and 5-HT in in vitro studies [10][11][12]. However, in one study clozapine markedly increased platelet aggregation induced by 5-HT [13].…”

Section: (Page Number Not For Citation Purposes)mentioning

confidence: 99%

The effect of atypical antipsychotics on platelet aggregation

Almuqdadi¹,

Bulatova²,

Yousef³

2016

Open J Hematol

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Background: There is a high prevalence of arterial thrombosis in schizophrenia. Several studies investigated the cause of this high risk among schizophrenic patients and variable finding reported. The aim of this study was to investigate whether second generation antipsychotics (risperidone, olanzapine and ziprasidone) exert antiplatelet action in the presence of different platelet agonists. Methods: We performed an in vitro study of different antipsychotics (risperidone, olanzapine and ziprasidone) effect on platelet aggregation induced by different platelet agonists (ADP, collagen, serotonin and epinephrine) when added to blood of healthy volunteers using Multiplate® analyzer. Results: Risperidone and ziprasidone but not olanzapine showed clinically significant inhibition of platelet aggregation induced by by serotonin, while only ziprasidone showed statistically significant inhibition on serotonin aggregation. All tested antipsychotics showed clinically (but not statistically) significant inhibition on platelet aggregation induced by epinephrine. On the other hand, no remarkable effect of antipsychotics on platelet aggregation induced by ADP or collagen was observed. Marked amplification reaction between serotonin and epinephrine was observed (AUC 66 U). When antipsychotics were added to serotonin-epinephrine combination, all of them produced AUC inhibition in a dose-dependent manner with highest potency for risperidone (IC50= 14.86 nM) and the lowest potency for olanzapine (IC50= 27.56 nM). Conclusion: All tested antipsychotics showed clinically (but not statistically) significant inhibition effect on platelet aggregation induced by either serotonin or epinephrine. All antipsychotics studied inhibited platelet aggregation induced by a combination of serotonin and epinephrine in a dose-dependent manner.

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Fish Oil and Antipsychotic Drug Risperidone Modulate Oxidative Stress in PC12 Cell Membranes Through Regulation of Cytosolic Calcium Ion Release and Antioxidant System

et al. 2010

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Oxidative stress is a critical route of damage in various psychological disorders such as schizophrenia, although fish oil and risperidone (RISP) induce antioxidant effects in the human body. However, the mechanisms behind these effects remain elusive. We investigated the effects of fish oil and RISP in the PC12 cell line by evaluating Ca(2+) mobilization, lipid peroxidation (LP) and antioxidant levels. PC12 cells were divided into eight flasks: control, fish oil, RISP, H(2)O(2), fish oil + H(2)O(2), RISP + H(2)O(2), fish oil + RISP and fish oil + RISP + H(2)O(2). Cells were incubated with fish oil and RISP for 24 and 48 h, respectively. Then, cells were exposed to H(2)O(2) for 15 min before analysis. Ca(2+) release and LP levels were higher in the H(2)O(2) group than in the control, RISP and fish oil groups, although their levels were decreased by incubation of cells in fish oil and RISP. Glutathione peroxidase activity, reduced glutathione and vitamin C levels in the cells were lower in the H(2)O(2) group than in the control, RISP and fish oil groups, although levels were higher in cells incubated with fish oil and RISP than in those in the H(2)O(2) groups. In conclusion, these results indicate that RISP and fish oil induced protective effects on oxidative stress in PC12 cells by modulating cytosolic Ca(2+) release and antioxidant levels.

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The effects of the second generation antipsychotics and a typical neuroleptic on collagen-induced platelet aggregationin vitro

Cited by 14 publications

References 36 publications

Innate Vascular Failure by Application of Neuroleptics, Amphetamine, and Domperidone Rapidly Induced Severe Occlusion/Occlusion-like Syndromes in Rats and Stable Gastric Pentadecapeptide BPC 157 as Therapy

Innate Vascular Failure by Application of Neuroleptics, Amphetamine, and Domperidone Rapidly Induced Severe Occlusion/Occlusion-like Syndromes in Rats and Stable Gastric Pentadecapeptide BPC 157 as Therapy

The effect of atypical antipsychotics on platelet aggregation

Fish Oil and Antipsychotic Drug Risperidone Modulate Oxidative Stress in PC12 Cell Membranes Through Regulation of Cytosolic Calcium Ion Release and Antioxidant System

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