The effects of the nonsteroidal anti-inflammatory drug diclofenac sodium on the rat kidney, and alteration by furosemide

Beşen, Ali Ayberk; Köse, Fatih; Paydaş, Saime; Gönlüşen, Gülfiliz; İnal, Tamer; Doğan, Alper; Ki̇bar, Mustafa; Balal, Mustafa

doi:10.1007/s11255-008-9496-7

Cited by 19 publications

(17 citation statements)

References 13 publications

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“…In our patients the administration of saline solution and furosemide was also effective in decreasing serum calcium levels and contributed to renal function recovery. Furosemide seems to play a protective role against drug nephrotoxicity [27]. Other cases of AKI associated with excess vitamin D intake have been reported [28,29].…”

Section: Discussionmentioning

confidence: 99%

Acute kidney injury due to anabolic steroid and vitamin supplement abuse: report of two cases and a literature review

et al. 2009

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AKI is an important complication of anabolic steroid and vitamin supplement abuse. The exact pathophysiology of this type of AKI remains unclear. The main cause of renal dysfunction in these cases seems to be the vitamin D intoxication and drug-induced interstitial nephritis. It is mandatory to start early treatment for serious hypercalcemia, with vigorous venous hydration, diuretics and corticosteroids.

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Section: Discussionmentioning

confidence: 99%

Acute kidney injury due to anabolic steroid and vitamin supplement abuse: report of two cases and a literature review

et al. 2009

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“…SD did not cause liver abnormalities, but it did increase the serum urea level. The ability of SD to inhibit cyclooxygenases 1 and 2 in non-selective media explains this adverse effect on the renal system, 35) as well as gastrointestinal effects described previously. 36) OLM is considered to be a cardioprotective drug, due to its anti-inflammatory activity (via inhibition of the AT1 receptor of angiotensin II) and antioxidant properties.…”

Section: Discussionmentioning

confidence: 66%

Olmesartan Prevented Intra-articular Inflammation Induced by Zymosan in Rats

Guerra

Menezes

Araújo

et al. 2016

Biological & Pharmaceutical Bulletin

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The objective of this study was to study the effect of olmesartan medoxomil (OLM), an antihypertensive drug, on intra-articular inflammation induced by zymosan (Zy) in Wistar rats. Intra-articular inflammation was induced in the right knees of rats by 1 mg Zy dissolved in saline. The animals were divided into the following groups: saline only (oral saline and intra-articular saline); Zy only (intra-articular Zy and oral saline), and intra-articular Zy and oral OLM (5, 15, or 30 mg/kg) or diclofenac sodium (SD; 100 mg/ kg). Twenty-four hours after Zy injection, synovial fluid was collected for total leukocyte counts, blood was collected for biochemical measurements, and synovial tissue was collected for histopathology, immunohistochemistry, immunofluorescence and myeloperoxidase (MPO), malonaldehyde (MDA), and non-protein sulphydryl (NPSH) assays. OLM doses of 15 and 30 mg/kg had protective effects, as evidenced by improved histopathological parameters of synovium, reduced total leukocyte counts, reduced MPO and MDA levels, and increased NPSH group levels compared with the Zy group. OLM reduced immunostaining for cyclooxygenase 2, tumour necrosis factor and interleukin 17 and increased immunostaining for superoxide dismutase and glutathione peroxidase. SD produced similar results. The drugs studied caused no change in biochemical parameters of the animals. OLM showed protective effects in this model of Zy-induced intra-articular inflammation.

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“…Many past studies have also confirmed diclofenac induced body weight loss in rats 10,11 . Many other NSAIDs also suppress the weight gain of mice resulting decrease in body weight 12 .…”

Section: S Of Anterior Latissimus Dorsi Muscle Of Diclofenac Treatedmentioning

confidence: 75%

Effects of Intramuscular Diclofenac Use on Lipid Peroxidation and Skeletal Muscle Histology in Balb-C Mice

Sharma¹,

Thakur²

2017

Int. Res. J. Pharm.

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Diclofenac is a nonsteroidal anti-inflammatory drug that is widely used for the treatment of musculoskeletal complaints, osteoarthritis, rheumatoid arthritis, ankylosing spondylitis and acute muscle pain conditions. There is considerable interest in the toxicity of diclofenac because of its clinical uses. In the present study, the sub-chronic administration of diclofenac (10 mg/kg body weight; 30 days) resulted in various changes in activity of SOD enzyme (a marker of oxidative stress) and lipid peroxidation levels of mice. Changes in the activity of enzyme represent adaptive responses in muscle after diclofenac treatment. Results show that diclofenac is a strong inducer of oxidative stress. Increase in the formation of thiobarbituric acid reactive species (TBARS) and SOD activity is observed which indicates a link between oxidative stress and muscular toxicity. Maximum increase is seen in drug treated mice at 30 days' stage of investigation.

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The effects of the nonsteroidal anti-inflammatory drug diclofenac sodium on the rat kidney, and alteration by furosemide

Cited by 19 publications

References 13 publications

Acute kidney injury due to anabolic steroid and vitamin supplement abuse: report of two cases and a literature review

Acute kidney injury due to anabolic steroid and vitamin supplement abuse: report of two cases and a literature review

Olmesartan Prevented Intra-articular Inflammation Induced by Zymosan in Rats

Effects of Intramuscular Diclofenac Use on Lipid Peroxidation and Skeletal Muscle Histology in Balb-C Mice

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