The Effects of the Heparin-Coated Maximum Arterial Re-Creation (MAC) Stent on Porcine Coronary Stent Restenosis

Park, Hyung Wook; Jeong, Myung Ho; Jang, Yang Soo; Kim, Yong Rok; Kim, Wan; Park, Woo Suck; Kim, Nam Ho; Kim, Joon‐Woo; Kim, Sung Hee; Cho, Jang Hyun; Ahn, Young Keun; Cho, Jung Gwan; Cho, Dong Lyun; Kim, Hyun Jin; Park, Jong Chun; Lee, Jae Hyuck; Park, Chang Soo; Kang, Jung Chaee

doi:10.4070/kcj.1999.29.5.498

Cited by 5 publications

(2 citation statements)

References 26 publications

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“…The role of caspases is crucial in intracellular apoptosis (Hou et al 2022; Park et al 2022; Sevimli, Bayram, Özgöçmen, Armağan, & Semerci Sevimli 2022). ISM1 has 14 invariant cysteine residues, of which the TRS1 structural domain contains 6 and the AMOP structural domain contains 8 (Ciccarelli et al 2002; Osório et al 2014).…”

Section: Biological Function Of Ism1mentioning

confidence: 99%

Advances in research of biological functions of Isthmin-1

Yang

Qianhe

et al. 2023

J. Cell Commun. Signal.

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Isthmin-1 (ISM1) was initially thought to be a brain secretory factor, but with the development of technical means of research and the refinement of animal models, numerous studies have shown that this molecule is expressed in multiple tissues, suggesting that it may have multiple biological functions. As a factor that regulates growth and development, ISM1 is expressed in different animals with spatial and temporal variability and can coordinate the normal development of multiple organs. Recent studies have found that under the dependence of a non-insulin pathway, ISM1 can lower blood glucose, inhibit insulin-regulated lipid synthesis, promote protein synthesis, and affect the body's glucolipid and protein metabolism. In addition, ISM1 plays an important role in cancer development by promoting apoptosis and anti-angiogenesis, and by regulating multiple inflammatory pathways to influence the body's immune response. The purpose of this paper is to summarize relevant research results from recent years and to describe the key features of the biological functions of ISM1. We aimed to provide a theoretical basis for the study of ISM1 related diseases, and potential therapeutic strategies. Graphical abstract The main biological functions of ISM1. Current studies on the biological functions of ISM1 focus on growth and development, metabolism, and anticancer treatment. During embryonic development, ISM1 is dynamically expressed in the zebrafish, African clawed frog, chick, mouse, and human, is associated with craniofacial malformations, abnormal heart localization, and hematopoietic dysfunction. ISM1 plays an important role in regulating glucose metabolism, lipid metabolism, and protein metabolism in the body. ISM1 affects cancer development by regulating cellular autophagy, angiogenesis, and the immune microenvironment.

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Section: Biological Function Of Ism1mentioning

confidence: 99%

Advances in research of biological functions of Isthmin-1

Yang

Qianhe

et al. 2023

J. Cell Commun. Signal.

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“…Green and blue green algae in Iraq are available in huge quantities, approximately in all surface water resources and marshes (Al-Hassany, 2003;Kassim, 2007). Fixed and fluidized beds have been used widely by chemical industry, pharmaceutical industry, food industry, wastewater treatment and recovery of different substance (Park et al, 1999). Fluidized beds are common and important reactors in process engineering because of the good mass and heat transfer rate between the fluid and the particles, and between the particles and the side wall of the column (Fu and Liu, 2007).…”

Section: Introductionmentioning

confidence: 99%

Multicomponent Biosorption of Heavy Metals Using Fluidized Bed of Algal Biomass

Sulaymon¹,

Mohammed²,

Al-Musawi³

2023

jcoeng

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This paper aims to study the biosorption for removal of lead, cadmium, copper and arsenic ions using algae as a biosorbent. A series of experiments were carried out to obtain the breakthrough data in a fluidized bed reactor. The minimum fluidization velocities of beds were found to be 2.27 and 3.64 mm/s for mish sizes of 0.4-0.6 and 0.6-1 mm diameters, respectively. An ideal plug flow model has been adopted to characterize the fluidized bed reactor. This model has been solved numerically using MATLAB version 6.5. The results showed a well fitting with the experimental data. Different operating conditions were varied: static bed height, superficial velocity and particle diameter. The breakthrough curves were plotted for each metal. Pb2+ showed the largest breakthrough time compared with others, while Cd2+ had the lowest value

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Inhibitory Effect of Double Coating with Echinomycin and Hydrophobic Heparin in a Porcine Coronary In-Stent Restenosis Model

et al. 2009

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Stent thrombosis and in-stent restenosis are still major limitations of coronary stenting. Here, we report on a new type of drug-eluting stent (DES) aimed to prevent restenosis and thrombosis. The DES was prepared by coating a bare metal stent with echinomycin (an anti-proliferative drug) and hydrophobic heparin. The echinomycin-hydrophobic heparin double-coating stents were compared with control stents in a porcine coronary stent restenosis model. Stent overdilation injury (stent : artery＝1.1 : 1.0) was compared in porcine coronary arteries between 4 groups: bare stent group (Group I, n=3), 1% echinomycin-heparin coating stent group (Group II, n=3), 5% echinomycin-heparin coating stent group (Group III, n=3), and 10% echinomycin-heparin coating stent group (Group IV, n=3). Follow-up quantitative coronary angiography was performed 4 weeks after the stents were inserted. The histopathologic assessments of the stented porcine coronary arteries were compared between the 4 groups. The neointimal areas of the stented arteries were 4.3±1.3 mm 2 in Group I, 5.7±1.3 mm 2 in Group II, 3.7±1.0 mm 2 in Group III, and 2.7±1.1 mm 2 in Group IV; the neointimal area was significantly larger in Group II than in the other groups (p＜0.001). The histopathologic areas of stenosis were 61.4±18.1% in Group I, 79.8±24.0% in Group II, 52.0±18.5% in Group III, and 30.9±14.6% in Group IV; the histopathologic area was significantly smaller in Group IV than in the other groups (p＜0.001). In conclusion, echinomycin-hydrophobic heparin double-coating stents effectively inhibit neointimal proliferation at a relatively high level.

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The Effects of the Heparin-Coated Maximum Arterial Re-Creation (MAC) Stent on Porcine Coronary Stent Restenosis

Cited by 5 publications

References 26 publications

Advances in research of biological functions of Isthmin-1

Advances in research of biological functions of Isthmin-1

Multicomponent Biosorption of Heavy Metals Using Fluidized Bed of Algal Biomass

Inhibitory Effect of Double Coating with Echinomycin and Hydrophobic Heparin in a Porcine Coronary In-Stent Restenosis Model

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