The Effects of the Carrier and Ligand Spatial Conformation on RNA Nanodrug Cell Delivery
Zhuang Zhang,
Siying Li,
Hongda Wang
et al.
Abstract:Small interfering RNA (siRNA) highlights the immense therapeutic potential for cancer treatment. The major challenge in siRNA therapy is the effective RNA nanodrug delivery system, which is facilitated by the ligand and the carrier. In this study, we analyzed the binding specificity of linear RGD and circular RGD to α V β 3 integrins by mapping the morphology using super-resolution direct stochastic optical reconstruction microscopy. Meanwhile, the binding dynamics was investigated using single-molecule force … Show more
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