Abstract:The role of adenosine A3 receptors and their distribution in the gastrointestinal tract have been widely investigated. Most of the reports discuss their role in intestinal inflammations. However, the role of adenosine A3 receptor agonist in pancreatitis has not been well established. The aim of this study is (Ed note: Purpose statements should be in present tense) to evaluate the effects of the adenosine A3 receptor agonist on the course of sodium taurocholate-induced experimental acute pancreatitis (EAP). The… Show more
“…11 A similar effect was described using an agonist of the A3 ADO receptor. 12 Considering the possible relationship between extracellular purines and AP, our group hypothesized that extracellular purinergic metabolism is accelerated in AP and is correlated with severity. In addition, serum phosphate may be increased due to nucleotide hydrolysis by ectonucleotidases.…”
“…11 A similar effect was described using an agonist of the A3 ADO receptor. 12 Considering the possible relationship between extracellular purines and AP, our group hypothesized that extracellular purinergic metabolism is accelerated in AP and is correlated with severity. In addition, serum phosphate may be increased due to nucleotide hydrolysis by ectonucleotidases.…”
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