The effects of temperature on the responses of Pacinian corpuscles

Inman, D. R.; Peruzzi, P

doi:10.1113/jphysiol.1961.sp006627

Cited by 49 publications

(32 citation statements)

References 22 publications

(39 reference statements)

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“…These authors also observed that conduction of the afferent nerve was maintained, suggesting that cooling resulted in a change in the ability of the mechanoreceptor itself to generate an action potential (Kunesch et al 1987). This is supported by work in the cat that found changes in the ability of isolated Pacinian corpuscles to initiate an action potential in response to mechanical stimulus when cooled (Inman and Peruzzi 1961). Although we did not systematically test this question, we often observed that increasing the amplitude of vibration was able to activate receptors once cooled, suggesting that cooling had caused an increase in the mechanical threshold of the receptor to be activated.…”

Section: Discussionmentioning

confidence: 80%

Cooling reduces the cutaneous afferent firing response to vibratory stimuli in glabrous skin of the human foot sole

Lowrey

Strzalkowski

Bent

2013

Journal of Neurophysiology

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Section: Discussionmentioning

confidence: 80%

Cooling reduces the cutaneous afferent firing response to vibratory stimuli in glabrous skin of the human foot sole

Lowrey

Strzalkowski

Bent

2013

Journal of Neurophysiology

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“…It has been consistently observed that the activation energy for mechanotransduction in vertebrate and invertebrate sensory receptors is very high compared with that of voltage-sensitive channels (Hoger and French 1999;Inman and Peruzzi 1961;Ishiko and Loewenstein 1961;Ottoson 1965). This is reflected by Q 10 values Ͼ3.0, measured for the amplitude of receptor potentials in the Pacinian corpuscle and spider mechanoreceptors (Hoger and French 1999;Ishiko and Loewenstein 1961).…”

Section: Discussionmentioning

confidence: 96%

Speed and Temperature Dependences of Mechanotransduction in Afferent Fibers Recorded From the Mouse Saphenous Nerve

Milenkovic¹,

Wetzel²,

Moshourab³

et al. 2008

Journal of Neurophysiology

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Milenkovic N, Wetzel C, Moshourab R, Lewin GR. Speed and temperature dependences of mechanotransduction in afferent fibers recorded from the mouse saphenous nerve. J Neurophysiol 100: 2771-2783, 2008. First published September 24, 2008 doi:10.1152/jn.90799.2008. Here we have systematically characterized the stimulus response properties of mechanosensitive sensory fibers in the mouse saphenous nerve. We tested mechanoreceptors and nociceptors with defined displacement stimuli of varying amplitude and velocity. For each sensory afferent investigated we measured the mechanical latency, which is the delay between the onset of a ramp displacement and the first evoked spike, corrected for conduction delay. Mechanical latency plotted as a function of stimulus strength was very characteristic for each receptor type and was very short for rapidly adapting mechanoreceptors (Ͻ11 ms) but very long in myelinated and unmyelinated nociceptors (49 -114 ms). Increasing the stimulus speed decreased mechanical latency in all receptor types with the notable exception of C-fiber nociceptors, in which mean mechanical latency was not reduced Շ100 ms, even with very fast ramp stimuli (2,945 m/s). We examined stimulus response functions and mechanical latency at two different temperatures (24 and 32°C) and found that stimulus response properties of almost all mechanoreceptors were not altered in this range. A notable exception to this rule was found for C-fibers in which mechanical latency was substantially increased and stimulus response functions decreased at lower temperatures. We calculated Q 10 values for mechanical latency in C-fibers to be 5.1; in contrast, the Q 10 value for conduction velocity for the same fibers was 1.4. Finally, we examined the effects of short-term inflammation (2-6 h) induced by carrageenan on nociceptor and mechanoreceptor sensitivity. We did not detect robust changes in mechanical latency or stimulus response functions after inflammation that might have reflected mechanical sensitization under the conditions tested.

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“…32 9°C in the case of Fig. 2A) were taken into account by making a correction using a Qlo of 3-5 (Inman & Peruzzi, 1961).…”

Section: Resultsmentioning

confidence: 99%

The influence of diameter of medullated nerve fibres of cats on the rising and falling phases of the spike and its recovery

Paintal¹

1966

The Journal of Physiology

144

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SUMMARY1. The relation of conduction velocity, i.e. fibre diameter (Hursh, 1939a) to certain temporal dimensions of the nerve impulse recorded monophasically was studied in medullated fibres of cats in vivo at temperatures mostly ranging between 21 and 370 C.2. Contrary to existing belief, it was demonstrated unequivocally that spike duration varies inversely with the conduction velocities of the fibres; so also the durations of the rising and the falling phases (rise-time and fall-time) of the impulse. The fall-time is linearly related to conduction velocity at all recorded temperatures. The rise-time varies steeply with conduction velocity at the lower levels of conduction rate, and very gradually at the higher conduction rates.3. The spike duration of preganglionic sympathetic fibres is identical with that of somatic medullated fibres with similar conduction velocities. There is therefore little justification for classifying them separately as so-called B fibres.4. The rate of recovery of spike amplitude following a preceding impulse also varies inversely with conduction velocity, and in the same manner as the absolute refractory period (ARP). In fact the relation of time for 40 % recovery of spike amplitude to conduction velocity is identical with the relation of conduction velocity to ARP. The Qlo for 40 % recovery of spike amplitude is 4*7 between 13 and 290 C.5. Rise-time increases exponentially with fall in temperature in all medullated fibres, fast (say 64 m/sec) and slow (say 16 m/sec), the Qlo being 2-5. Fall-time varies exponentially with temperature in slow fibres (Qlo = 3.5); in fast fibres it varies linearly. The Qlo for spike duration is the same in all fibres between 27 and 370 C only, its value being about 3-4. Below 270 C the Qlo depends on the conduction velocity of the fibres.Only in slow fibres does spike duration tend to vary exponentially with temperature.6. Only abortive spikes are generated during the interval between the end of a preceding spike and the end of the ARP which is about 1i times spike duration in fast fibres and about twice spike duration in slow fibres.

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The effects of temperature on the responses of Pacinian corpuscles

Cited by 49 publications

References 22 publications

Cooling reduces the cutaneous afferent firing response to vibratory stimuli in glabrous skin of the human foot sole

Cooling reduces the cutaneous afferent firing response to vibratory stimuli in glabrous skin of the human foot sole

Speed and Temperature Dependences of Mechanotransduction in Afferent Fibers Recorded From the Mouse Saphenous Nerve

The influence of diameter of medullated nerve fibres of cats on the rising and falling phases of the spike and its recovery

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