This study compares the effects of ion and neutron irradiation on Fe 6%Cr irradiated to the same dose and at the same temperature by these two methods, and compared with unirradiated material. In recent work reported elsewhere, the materials were characterised by Transmission Electron Microscopy (TEM) and Atom Probe Tomography (APT). This paper reports further investigation of the alloy using nanoindentation and micromechanical testing. Irradiated and un-irradiated micro-cantilevers with a wide range of dimensions were used to study the interrelationships between irradiation hardening and size effects in small-scale plasticity. TEM and APT results identified that the dislocation loop densities were ~2.9x1022m-3 for the neutron irradiated material and only ~1.4x1022m-3 for the ion irradiated material. Cr segregation to loops was only found for the neutron-irradiated material. The nanoindentation hardness increase due to neutron irradiation was 3 GPa, and that due to ion irradiation 1 GPa. The differences between the effects of the two irradiation types are discussed, taking into account inconsistencies in damage calculations, and the differences in PKA spectra, dose rate and transmutation products for the two irradiation types. Nanoindentation was conducted with an MTS NANO Indenter XP (MTS NANO Oak Ridge Tennessee, USA) with a single Berkovich tip; the tip shape was calibrated before each test series. The "continuous stiffness measurement" (CSM) indentation and analysis method [7] was used to make at least 16 indents with a depth of 1000 nm in each sample, in arrays with a indent-to-indent spacing of 40 µm. The amplitude and frequency of the CSM technique was 2 nm and 45 Hz respectively. Due to the small grain size of the samples, data from each indent series, averaged across all indents, includes the response of several grains. Micro-cantilevers were manufactured by Focused Ion Beam (FIB) milling in the un-irradiated and ion irradiated material using a Zeiss Auriga FIB/SEM dual beam system in the Department of Materials, Oxford University. Micro-cantilevers were manufactured in the neutron irradiated material using the 'hot' FEI Quanta dual beam microscope at the Center for Advanced Energy Studies in Idaho Falls (USA). The following test specimens were produced: i. Neutron irradiated sample-66 cantilevers with cross-sectional heights from 0.82 to 7.30 µm (figure 3). ii. Ion irradiated sample-30 cantilevers with cross-sectional heights from 0.36 to 2.3 µm iii. Un-irradiated sample-32 cantilevers with cross-sectional heights from 0.53 to 5.11 µm The cantilever beams were FIB milled by using various beam currents depending on the beam size and were finished with lower polishing currents to achieve a geometry with sharp edges. The All beams were measured by stereo-imaging techniques using the principles described in ref. [8]. Tests were conducted using the Nano-XP nanoindenter by bending the beams to a final maximum peak strain (at the lower surface at the beam root), , of ~0.05 and a target strain rate at the beam ...