The effects of systemic isotretinoin and antibiotic therapy on the microbial floras in patients with acne vulgaris

Başak, Pınar Yüksel; Çetin, Emel Sesli; Gürses, İclal; Özseven, Alper

doi:10.1111/j.1468-3083.2011.04397.x

Cited by 17 publications

(14 citation statements)

References 32 publications

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“…Higher rates of colonization with S aureus have been seen in patients taking systemic isotretinoin, leading to increased rates of minor skin infections, such as folliculitis and furunculosis. 300,301 On rare occasions, the combination of cheilitis and S aureus colonization can cause lip or perioral abscesses, a serious complication requiring prompt attention. 300 The teratogenic effects of isotretinoin and the risk for retinoic acid embryopathy are well known.…”

Section: Hormonal Agentsmentioning

confidence: 99%

“…300,301 On rare occasions, the combination of cheilitis and S aureus colonization can cause lip or perioral abscesses, a serious complication requiring prompt attention. 300 The teratogenic effects of isotretinoin and the risk for retinoic acid embryopathy are well known. After introduction of isotretinoin in the United States in 1982, there were hundreds of reports of isotretinoinexposed pregnancies within just several years, resulting in a high rate of congenital malformations.…”

Section: Hormonal Agentsmentioning

confidence: 99%

See 1 more Smart Citation

Guidelines of care for the management of acne vulgaris

Zaenglein

Pathy

Schlosser

et al. 2016

Journal of the American Academy of Dermatology

1,136

1,424

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Acne is one of the most common disorders treated by dermatologists and other health care providers. While it most often affects adolescents, it is not uncommon in adults and can also be seen in children. This evidence-based guideline addresses important clinical questions that arise in its management. Issues from grading of acne to the topical and systemic management of the disease are reviewed. Suggestions on use are provided based on available evidence.

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Section: Hormonal Agentsmentioning

confidence: 99%

Section: Hormonal Agentsmentioning

confidence: 99%

Guidelines of care for the management of acne vulgaris

Zaenglein

Pathy

Schlosser

et al. 2016

Journal of the American Academy of Dermatology

1,136

1,424

View full text Add to dashboard Cite

show abstract

“…Oral isotretinoin induces changes in the type and number of microorganisms that colonize the skin and anterior nasal mucosa, with increased colonization by Staphylococcus aureus and a marked reduction in Propionibacterium acnes from the start of treatment that continues after treatment ends. 75…”

Section: Skin Microfloramentioning

confidence: 99%

<p>Challenges and Solutions in Oral Isotretinoin in Acne: Reflections on 35 Years of Experience</p>

Bettoli¹,

Guerra‐Tapia²,

Herane³

et al. 2019

CCID

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Acne vulgaris affects more than 80% of adolescents and young adults and forms a substantial proportion of the dermatologist's and general practitioner's caseload. Severity of symptoms varies but may result in facial scarring and psychological repercussions. Oral isotretinoin is highly effective but can only be prescribed by specialists. Side effects are recognized and mostly predictable, ranging from cosmetic effects to teratogenicity. These can affect patients' quality of life and treatment adherence. This article provides a commentary on 4 key areas: the use of oral isotretinoin vs oral antibiotics, including the importance of early recognition of nonresponse to treatment, the psychological effects of acne and isotretinoin treatment, the side effects of isotretinoin therapy, and cosmetic treatment options that can help alleviate predictable side effects. The authors, who have all participated in various international expert groups, draw on relevant literature and their extensive professional experience with oral isotretinoin in the treatment of acne. The aim of this article is to provide an informative and practical approach to managing oral isotretinoin treatment in patients with acne, to help optimize treatment of this skin disease.

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“…Başak ve ark. 13 benzer bir çalışmada isotretinoin tedavisi alan akneli hastalarda nazal MSSA kolonizasyonunu tedavi öncesinde %15 (n=3), 4-6 aylık tedavi sonrasında %70 (n=14) olarak bildirmişlerdir. Tedavi sonrasında elde edilen 14 izolatın 2'sinin MRSA olduğunu tespit etmişlerdir.…”

Section: Discussionunclassified

Assessment of nasal carriage of staphylococcus aureus in patients with acne vulgaris

Demir¹,

Denk²,

Erden³

et al. 2015

TURKDERM

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Background and Design: Systemic antibiotics, such as tetracycline and doxycycline are used in the treatment of inflammatory forms of moderate acne, or acne that is resistant to topical treatment. Oral isotretinoin treatment is the most effective treatment option in severe papulopustular and nodular forms of acne. Dose-related nasal carrier state of Staphylococcus aureus (S. aureus), has been reported in 90% of patients using isotretinoin. Long-term oral and/or topical antibiotic use in the treatment of acne causes changes in antibiotic susceptibility and emergence of methicillin-resistant S. aureus (MRSA) pathogens. The present retrospective study examined the colonization rates of S. aureus in patients who had an increase in acneiform lesions while taking medications for the treatment of acne and whose nasal swap samples were obtained and also investigated their relationship with treatment options. Materials and Methods: A total of 86 patients with moderate acne who attended our dermatology outpatient clinic with the complaints of acne and in whom nasal swap samples were obtained due to increased pustules during acne therapy. The patients were divided into three groups according to the treatment methods as patients receiving topical treatment, patients treated with oral doxycycline, and patients treated with oral isotretinoin. The results of the cultures were evaluated in three groups: no growth, methicillin-sensitive S. aureus (MSSA), and MRSAisolated.

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The effects of systemic isotretinoin and antibiotic therapy on the microbial floras in patients with acne vulgaris

Cited by 17 publications

References 32 publications

Guidelines of care for the management of acne vulgaris

Guidelines of care for the management of acne vulgaris

<p>Challenges and Solutions in Oral Isotretinoin in Acne: Reflections on 35 Years of Experience</p>

Assessment of nasal carriage of staphylococcus aureus in patients with acne vulgaris

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