“…For example, strong interactions between protein molecules and the surface, such as occur upon adsorption onto hydrophobic surfaces, often lead to structural alterations in the protein structure (1,3,5,6,9,12,14). For the contact of proteins with hydrophilic silica surfaces, both similar structural features as adopted by the protein in solution (5,12,13) and adsorption-induced structural changes (14, 21) have been observed.…”