The effects of subthalamic deep brain stimulation on metaphor comprehension and language abilities in Parkinson’s disease

Tremblay, Cyntia; Macoir, Joël; Langlois, Mélanie; Cantin, Léo; Prudhomme, Michel; Monetta, Laura

doi:10.1016/j.bandl.2014.12.004

Cited by 15 publications

(13 citation statements)

References 51 publications

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“…The comparison between on-and off-conditions of DBS may be more indicative of the effect of the stimulation. Some previous studies using this approach found no differences in phonemic verbal fluency 12,13,14,23 , corroborating our analysis with the full sample, in which we did not find any effect of DBS on the phonemic fluency, despite finding a positive effect of the stimulation on the motor function.…”

Section: Variable M (Sd) or N (%)supporting

confidence: 81%

“…Among the adverse effects of STN-DBS in patients with PD, the postoperative decline in verbal fluency is well documented 4,5,6,7,8,9,10,11 . However, there are fewer studies about the effect of the stimulation per se, comparing on-and off-stimulation conditions 12,13,14 . Longitudinal studies verified a worsening of verbal fluency in the first months after surgery, but an improvement in the later studied months 9 .…”

Section: Subthalamic Nucleus Deep Brain Stimulation (Stn-dbs)mentioning

confidence: 99%

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Different outcomes of phonemic verbal fluency in Parkinson’s disease patients with subthalamic nucleus deep brain stimulation

Romann

Beber

Olchik

et al. 2017

Arq. Neuro-Psiquiatr.

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Subthalamic nucleus deep brain stimulation (STN-DBS) is a surgical technique to treat motor symptoms in patients withParkinson's disease (PD). Studies have shown that STN-DBS may cause a decline in verbal fluency performance. We aimed to verify the effects of STN-DBS on the performance of phonemic verbal fluency in Brazilian PD patients. Sixteen participants were evaluated on the Unified Parkinson's Disease Rating Scale -Part III and for phonemic fluency ("FAS" version) in the conditions of on-and off-stimulation. We identified two different patterns of phonemic verbal fluency outcomes. The results indicate that there may be no expected pattern of effect of bilateral STN-DBS in the phonemic fluency, and patients may present with different outcomes for some reason not well understood.Keywords: Parkinson disease; deep brain stimulation; language; cognition. RESUMOA estimulação cerebral profunda do núcleo subtalâmico (ECP-NST) é uma técnica cirúrgica para tratar sintomas motores na doença de Parkinson (DP). Estudos têm mostrado que ECP-NST pode causar um declínio no desempenho de fluência verbal. O objetivo do estudo foi verificar os efeitos da ECP-NST sobre o desempenho da fluência verbal fonêmica em indivíduos brasileiros com DP. Dezesseis participantes foram avaliados quanto ao desempenho motor (UPDRS-III) e à fluência verbal fonêmica (versão "FAS") nas condições de estimulação ligada e desligada. Identificamos dois padrões diferentes de resultados de fluência verbal fonêmica. Os resultados indicam que pode não haver um padrão esperado de efeito de ECP-NST bilateral na fluência fonêmica, e os pacientes podem apresentar desfechos diferentes de acordo com alguma razão não bem compreendida.Palavras-chave: doença de Parkinson; estimulação encefálica profunda; linguagem; cognição. Subthalamic nucleus deep brain stimulation (STN-DBS)is a procedure used to treat patients with Parkinson's disease (PD) when pharmacological treatment is no longer efficient 1 . It has been proven that DBS suppresses motor symptoms and reduces the total dose of the antiparkinsonian drugs 2,3 . Among the adverse effects of STN-DBS in patients with PD, the postoperative decline in verbal fluency is well documented 4,5,6,7,8,9,10,11 . However, there are fewer studies about the effect of the stimulation per se, comparing on-and off-stimulation conditions 12,13,14 . Longitudinal studies verified a worsening of verbal fluency in the first months after surgery, but an improvement in the later studied months 9 . These authors suggest that this effect of the DBS on the verbal fluency may be due to the micro-lesions caused by the implantation procedure of the electrodes in the STN.The verbal fluency test evaluates the capacity to search and retrieve data stored in long-term memory within a certain category and demonstrates the capacities of

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Section: Variable M (Sd) or N (%)supporting

confidence: 81%

Section: Subthalamic Nucleus Deep Brain Stimulation (Stn-dbs)mentioning

confidence: 99%

Different outcomes of phonemic verbal fluency in Parkinson’s disease patients with subthalamic nucleus deep brain stimulation

Romann

Beber

Olchik

et al. 2017

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

show abstract

“…Third, all studies did not assess patients in the same pharmacological condition, with most studies assessing patients ON antiparkinsonian medications, some studies assessing them OFF antiparkinsonian medications [ 38 , 51 – 53 , 63 , 67 , 75 ], and some other studies assessing them in a nonhomogenous way [ 25 ]. Some authors did not specify the medication and/or stimulation status of the patients at the time of cognitive evaluation [ 27 , 28 , 35 ]. Finally, cognitive worsening after DBS might be at least partially secondary to a postoperative reduction in antiparkinsonian medications, which is seen more after STN DBS than GPi DBS [ 9 , 34 ].…”

Section: Discussionmentioning

confidence: 99%

Cognitive Impact of Deep Brain Stimulation on Parkinson’s Disease Patients

Mehanna

Bajwa

Fernández

et al. 2017

Parkinson's Disease

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Subthalamic nucleus (STN) or globus pallidus interna (GPi) deep brain stimulation (DBS) is considered a robust therapeutic tool in the treatment of Parkinson's disease (PD) patients, although it has been reported to potentially cause cognitive decline in some cases. We here provide an in-depth and critical review of the current literature regarding cognition after DBS in PD, summarizing the available data on the impact of STN and GPi DBS as monotherapies and also comparative data across these two therapies on 7 cognitive domains. We provide evidence that, in appropriately screened PD patients, worsening of one or more cognitive functions is rare and subtle after DBS, without negative impact on quality of life, and that there is very little data supporting that STN DBS has a worse cognitive outcome than GPi DBS.

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“…Several instruments were used to assess the EF of PD patients with STN-DBS, but the most recurrent were verbal fluency tasks, both semantic and phonemic,13 , 14 , 16 - 18 , 20 , 21 , 23 , 26 , 27 , 29 , 30 , 32 , 34 , 35 , 37 , 38 followed by the WCST 1316 , 18 , 23 , 30 , 32 , 34 These tasks, in particular, underwent different adaptations in each article.…”

Section: Discussionmentioning

confidence: 99%

“…Few articles assessed Language,14 , 35 , 37 Attention,23 Perception35 and Visuospatial Skills 2736 One study43 reported PD patients without dementia who exhibited impairment in verbal comprehension, grammatically complex sentence identification, repetitive speech, decreased abstraction capacity, slow processing speed and attention deficit 44.…”

Section: Discussionmentioning

confidence: 99%

Systematic review of neuropsychological instruments used in subthalamic nucleus deep brain stimulation in Parkinson´s disease patients

Barbosa

Charchat‐Fichman

2019

Dement. neuropsychol.

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ABSTRACT. In addition to drug treatment, surgical intervention represents an alternative to PD patients with motor deficits. The most common intervention is subthalamic nucleus deep brain stimulation (STN-DBS). It is extremely important to perform a neuropsychological assessment in patients with STN-DBS, not only to identify losses related to the disease, but also to compare influence on cognition both pre and postoperatively. Objective: the objective of this systematic review was to investigate the instruments frequently used in studies related to STN-DBS in PD patients. Methods: articles were retrieved from Medline/Pubmed databases published in the 2007-2017 period using PRISMA criteria. Results: after analyzing 27 articles, the absence of a specific evaluation protocol for PD with STN-DBS was evident. Conclusion: non-motor symptoms are not given due importance in neuropsychological assessments. It is crucial to acknowledge that these symptoms have a major impact on the quality of life of patients. Greater engagement in assessing these aspects is required, in order to bridge the gaps in research.

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The effects of subthalamic deep brain stimulation on metaphor comprehension and language abilities in Parkinson’s disease

Cited by 15 publications

References 51 publications

Different outcomes of phonemic verbal fluency in Parkinson’s disease patients with subthalamic nucleus deep brain stimulation

Different outcomes of phonemic verbal fluency in Parkinson’s disease patients with subthalamic nucleus deep brain stimulation

Cognitive Impact of Deep Brain Stimulation on Parkinson’s Disease Patients

Systematic review of neuropsychological instruments used in subthalamic nucleus deep brain stimulation in Parkinson´s disease patients

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