The Effects of Stress on Measures of Alcohol Drinking in Rodents

Radke, Anna K.; Pickens, Charles L.; Holmes, Andrew

doi:10.1016/b978-0-12-405941-2.00006-7

Cited by 4 publications

(5 citation statements)

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“…Consumption of ethanol could be described as a stressor in and of itself. Ethanol exposure has been found to increase activity in the hypothalamic-pituitary-adrenal (HPA) axis, and withdrawal from ethanol has been associated with increased levels of corticotropin releasing factor (Radke et al, 2014). Thus, ethanol exposure in adolescence may be necessary to reveal the effects of infant footshock on aversion-resistant drinking, possibly by acting as a secondary stressor that potentiates the effects of infant footshock.…”

Section: Discussionmentioning

confidence: 99%

“…In preclinical studies, stress has been found to have wide-ranging effects on ethanol drinking behavior (e.g., Becker et al, 2011; Radke et al, 2014), although at least one prior review of the literature estimated that acute stress increased drinking in fewer than 50% of studies (Becker et al, 2011). The limited and/or variable effects of acute stress exposure on drinking are in contrast with chronic stress exposure, which increase drinking behaviors much more consistently, especially when administered in early stages of development (Becker et al, 2011; Radke et al, 2014). The current set of experiments examined the effects of acute, infant footshock on adult drinking behaviors in mice, based on prior demonstrations that this protocol can potentiate alcohol drinking behaviors in rats (Meyer et al, 2013; Radke et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

“…Long-Evans rats are an outbred line, and thus in a given set of subjects there is increased genetic diversity compared to the inbred C57BL/6J line. The effect of stress on ethanol consumption has been found to vary between mouse strains (Radke et al, 2014). Furthermore, PTSD-AUD comorbidity is not ubiquitous in individuals who have experienced trauma (Gilpin & Weiner, 2017; Young-Wolff et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

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Effects of early life stress paired with adolescent alcohol consumption on two-bottle choice alcohol drinking behaviors in mice

Perry

Sneddon

Reichert

et al. 2023

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In humans, early life stress (ELS) is associated with an increased risk for developing both alcohol use disorder (AUD) and post-traumatic stress disorder (PTSD). We have previously used an infant footshock model to explore this shared predisposition. Infant footshock produces stress-enhanced fear learning (SEFL) in rats and mice and increases aversion resistant alcohol drinking in rats. The goal of the current study was to extend this model of comorbid PTSD and AUD to male and female C57BL/6J mice. Acute ELS was induced using 15 foot-shocks on postnatal day 17. In adulthood, after PND 90, ethanol drinking behavior was tested in one of three two-bottle choice drinking paradigms: continuous access, limited access drinking in the dark, or intermittent access. In continuous access, mice were given 24h access to 5% or 10% ethanol and water. Each ethanol concentration was provided for five consecutive drinking sessions. In limited access drinking in the dark, mice were given 2 hours of access to 15% ethanol and water across 15 sessions. Ethanol was provided three hours into the dark cycle so as to maximize task engagement. In intermittent access, mice were presented with 20% ethanol and water Monday, Wednesday and Friday, for four consecutive weeks. In a fifth week of intermittent access drinking, increasing concentrations of quinine (10 mg/L, 100 mg/L, 200 mg/L) were added to the ethanol to test aversion-resistant drinking. Our results indicate that infant footshock does not influence adult ethanol consumption in mice. Infant footshock did not affect ethanol-only consumption or preference in any of the three drinking paradigms. Further, and in contrast to our previous results in rats, infant footshock did not appear to influence consumption of quinine-adulterated ethanol. The biological sex of the mice did affect ethanol-only consumption in all three drinking paradigms, with females consuming more ethanol than males. Preference for ethanol vs. water was higher in females only under continuous access conditions. Our results suggest that infant footshock alone may not be sufficient to increase drinking levels in mice. We hypothesize that infant footshock may require a secondary, adolescent stress exposure to influence ethanol drinking behavior. Further research is needed to create a valid model of PTSD-AUD comorbidity in male and female mice.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Effects of early life stress paired with adolescent alcohol consumption on two-bottle choice alcohol drinking behaviors in mice

Perry

Sneddon

Reichert

et al. 2023

Preprint

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“…The effects of stress on alcohol drinking are variable and dependent on a number of factors, including animal strain and the timing, duration, and nature of the stressor 20,32,65 . Because childhood stress exposure predicts early-onset adolescent drinking in humans, we were interested in whether acute ELS would alter alcohol drinking in adolescence or adulthood.…”

Section: Discussionmentioning

confidence: 99%

“…PTSD and AUD exhibit significant comorbidity in clinical populations, suggesting that the neural substrates mediating vulnerability for these two disorders may be similar [27][28][29][30][31] . While acute stress does increase rodent alcohol consumption in some studies, results are inconsistent 20,32 . Rats exposed to an adult SEFL protocol have been shown to develop subsequent increases in voluntary alcohol consumption, suggesting that this type of manipulation may be suitable for studying stress-induced increases in alcohol drinking behaviors 33 .…”

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Additive influences of acute early life stress and sex on vulnerability for aversion‐resistant alcohol drinking

et al. 2019

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Acute early life stress (ELS) alters stress system functioning in adulthood and increases susceptibility to posttraumatic stress disorder (PTSD) and alcohol use disorder (AUD). The current study assessed the effects of acute, infant ELS on alcohol drinking, including aversion-resistant drinking, in male and female Long Evans rats. Acute ELS was induced using a stress-enhanced fear learning (SEFL) protocol that consisted of 15 footshocks delivered on postnatal day (PND) 17. Alcohol drinking during adolescence and adulthood was measured with a two-bottle choice intermittent alcohol access paradigm. Aversion-resistant drinking was assessed in adulthood by adding quinine (0.01, 0.1, and 1.0 g/L) to the alcohol bottle after 5 to 6 weeks and 11 to 12 weeks of drinking. ELS had minimal influences on adolescent and adult alcohol consumption and preference. However, ELS, sex, and alcohol exposure history all influenced aversion-resistant alcohol drinking in an additive fashion. Higher concentrations of quinine were tolerated in females, ELS-exposed rats, and after 11 to 12 weeks of drinking. Tests of quinine sensitivity in a separate cohort of animals found that rats can detect concentrations of quinine as low as 0.001 g/L in water and that quinine sensitivity is not influenced by sex or ELS exposure. These results agree with reports of sex differences in aversion-resistant drinking and are the first to demonstrate an influence of ELS on this behavior. Our results also suggest that a single traumatic stress exposure in infancy may be a promising model of comorbid PTSD and AUD and useful in studying the interactions between ELS, sex, and alcohol dependence. K E Y W O R D S (6) alcohol, compulsive drinking, early life stress, quinine, sex differences, stress enhanced fear learning 1 | INTRODUCTION Drinking in spite of negative consequences is a core feature of alcohol use disorder (AUD) 1. In rodents, this behavior is modeled by pairing an aversive stimulus with alcohol delivery 2-6. For example, rats with extended alcohol exposure have been shown to consume alcohol adulterated with the bitter tastant quinine 7,8. Such models of "aversion-resistant drinking" have been used to reveal important insights into the neurobiology of alcohol dependence 9-12. Early life stress (ELS) is associated with a number of adverse outcomes in humans, including psychopathology and an increased propensity for alcohol and drug dependence 13-17. Exposure to childhood

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Distinct roles of the left and right prelimbic cortices in the modulation of ethanol consumption in male mice under acute and chronic social defeat stress

Canto-de-Souza,

Baptista-de-Souza,

Nunes-de-Souza

et al. 2024

Psychopharmacology

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The Effects of Stress on Measures of Alcohol Drinking in Rodents

Cited by 4 publications

References 191 publications

Effects of early life stress paired with adolescent alcohol consumption on two-bottle choice alcohol drinking behaviors in mice

Effects of early life stress paired with adolescent alcohol consumption on two-bottle choice alcohol drinking behaviors in mice

Additive influences of acute early life stress and sex on vulnerability for aversion‐resistant alcohol drinking

Distinct roles of the left and right prelimbic cortices in the modulation of ethanol consumption in male mice under acute and chronic social defeat stress

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