The effects of stress on wound healing in male tree lizards (Urosaurus ornatus)

French, Susannah S.; Matt, Kathleen S.; Moore, Michael C.

doi:10.1016/j.ygcen.2005.08.005

Cited by 97 publications

(101 citation statements)

References 21 publications

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Section: Discussionsupporting

confidence: 63%

“…A number of studies using a variety of animal species and stressors report that stress is associated with delayed healing [35,36,73]. Consistent with the human studies, this finding has been reported across different wound models, including punch-biopsy cutaneous wounds and tape-stripped skin [35,36,74,75]. It is interesting that a comparison of the size of the relationship found by this metaanalysis with that reported by a frequently cited animal study investigating the impact of restraint upon the time taken for a cutaneous punch biopsy wound in a murine wound model to heal [73] (r=−0.79 experiment 1, r=−0.94 experiment 2) indicates a stronger negative impact of stress upon wound healing.…”

Section: Discussionmentioning

confidence: 99%

“…Only studies with human participants were included since the stress paradigms used in animal studies, such as enforced social disruption [35] or periods of restraint [35,36], are qualitatively different to those used in studies using human participants.…”

Section: Participantsmentioning

confidence: 99%

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Psychological stress and wound healing in humans: A systematic review and meta-analysis

Walburn

Vedhara

Hankins

et al. 2009

Journal of Psychosomatic Research

281

187

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(2009) Psychological stress and wound healing in humans: a systematic review and meta-analysis. Journal of Psychosomatic Research, 67 (3). pp. [253][254][255][256][257][258][259][260][261][262][263][264][265][266][267][268][269][270][271] This version is available from Sussex Research Online: http://sro.sussex.ac.uk/2232/ This document is made available in accordance with publisher policies and may differ from the published version or from the version of record. If you wish to cite this item you are advised to consult the publisher's version. Please see the URL above for details on accessing the published version. Copyright and reuse:Sussex Research Online is a digital repository of the research output of the University.Copyright and all moral rights to the version of the paper presented here belong to the individual author(s) and/or other copyright owners. To the extent reasonable and practicable, the material made available in SRO has been checked for eligibility before being made available.Copies of full text items generally can be reproduced, displayed or performed and given to third parties in any format or medium for personal research or study, educational, or not-for-profit purposes without prior permission or charge, provided that the authors, title and full bibliographic details are credited, a hyperlink and/or URL is given for the original metadata page and the content is not changed in any way. Abstract Objective: The current review aims to synthesize existing knowledge about the relationship between psychological stress and wound healing. Methods: A systematic search strategy was conducted using electronic databases to search for published articles up to the end of October 2007. The reference lists of retrieved articles were inspected for further studies and citation searches were conducted. In addition, a meta-analysis of a subset of studies was conducted to provide a quantitative estimation of the influence of stress on wound healing. Results: Twenty-two papers met the inclusion criteria of the systematic review and a subsample of 11 was included in a meta-analysis. The studies assessed the impact of stress on the healing of a variety of wound types in different contexts, including acute and chronic clinical wounds, experimentally created punch biopsy and blister wounds, and minor damage to the skin caused by tape stripping. Seventeen studies in the systematic review reported that stress was associated with impaired healing or dysregulation of a biomarker related to wound healing. The relationship between stress and wound healing estimated by the meta-analysis was r=−0.42 (95% CI=−0.51 to −0.32) (Pb.01). Conclusion: Attention now needs to be directed towards investigating potential moderators of the relationship, mediating mechanisms underpinning the association, as well as the demonstration of a causal link by the development of experimental interventions in healthy populations.

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Section: Discussionsupporting

confidence: 63%

Section: Discussionmentioning

confidence: 99%

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Psychological stress and wound healing in humans: A systematic review and meta-analysis

Walburn

Vedhara

Hankins

et al. 2009

Journal of Psychosomatic Research

281

187

View full text Add to dashboard Cite

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“…Because most experiments aim to extrapolate to humans, mammals are usually used, although e.g. chicken chorioallantoic membrane can be used for angiogenesis assays 51 and the effect of stress on wound healing has been investigated in lizards 52 . Rats, mice, pigs and rabbits are the most frequently used animals.…”

Section: In Vivo Assaysmentioning

confidence: 99%

Models for the study of skin wound healing. The role of Nrf2 and NF-κB

Ambrožová¹,

Ulrichová²,

Galandáková³

2017

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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a,bNrf2 and NF-κB transcription factors act in wound healing via their anti-inflammatory and anti-oxidant effects or through the immune response. Studying this process is a matter of some importance given the high cost of wound treatment. A major contribution in this regard is being made by models that enable investigation of the involvement of multiple factors in wound healing and testing new curative substances. This literature review was carried out via searches in the PubMed and Web of Science databases up to 2016. It covers skin wound healing, available models for its study (part I), the role of Nrf2 and NF-κB, substances that influence them and whether they can be used as markers (part II). Was found that in vitro assays are used for their availability but a holistic view must be established in vivo. In silico approaches are facilitating assessment of a vast amount of research data. Nfr2 and NF-κB play a crucial and reciprocal role in wound healing. Nrf2 controls repair-associated inflammation and protects against excessive accumulation of ROS while Nf-κB activates the innate immune reaction, proliferation and migration of cells, modulates expression of matrix metalloproteinases, secretion and stability of cytokines and growth factors for wound healing.

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“…However, this does not imply that arbitrarily subjecting the turtles to acute stressors is consistent with good animal care, and there exists the potential that repeated acute stress episodes may lead to compromised wound healing and pathology (French et al 2005;Warwick 2004). …”

Section: Behavioural Considerationsmentioning

confidence: 99%

Welfare and Environmental Implications of Farmed Sea Turtles

Arena

Warwick²,

Steedman³

2013

J Agric Environ Ethics

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Various captivity-related health problems have been described as arising in the farming of sea turtles at the Cayman Turtle Farm (CTF). Our study included a desktop review of turtle farming, direct onsite inspection at the CTF, assessment of visual materials and reports provided by investigators from the World Society for the Protection of Animals (WSPA), and a limited analysis of water quality for potential pathogens. In particular, we assessed physical and behavioural condition of animals for signs of stress, injury and disease. During the onsite inspection we identified three distinct signs of physical injury and disease, six distinct signs of abnormal and problematic arousal-and discomfort-related behaviour; and three distinct signs of normal quiescence-and comfort-related behaviour. On evaluation of evidence provided by the WSPA we identified ten distinct signs of physical injury and disease, and managementor genetic-related conditions; six distinct signs of abnormal and problematic arousaland discomfort-related behaviour; and three distinct signs of normal quiescence-and comfort-related behaviour. We conclude that sea turtles at the CTF manifested important physical and behavioural signs that are indicative of problematic management and captivity-related stress, and the limitations of sea turtle adaptive plasticity in captivity. The problematic physical and behavioural signs, in our view, related to the inherent nature of intensive turtle propagation which in particular involves overt-and cryptoovercrowding and understimulating environments, and an associated failure to meet all the physical, biological and innate behavioural needs of sea turtles.

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The effects of stress on wound healing in male tree lizards (Urosaurus ornatus)

Cited by 97 publications

References 21 publications

Psychological stress and wound healing in humans: A systematic review and meta-analysis

Psychological stress and wound healing in humans: A systematic review and meta-analysis

Models for the study of skin wound healing. The role of Nrf2 and NF-κB

Welfare and Environmental Implications of Farmed Sea Turtles

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