The effects of statin therapy on inflammatory cytokines in patients with bacterial infections: a randomized double-blind placebo controlled clinical trial

Abstract

Statin therapy may be associated with a reduction in the levels of inflammatory cytokines in patients with acute bacterial infections. Large controlled trials will determine if this reduction will translate into a clinical benefit.

Association of Statin Use with Risk and Outcome of Acute Kidney Injury in Community-Acquired Pneumonia

“…Statins have many pleiotrophic effects (12)(13)(14), and although some studies suggest that these pleiotrophic effects may decrease the risk for severe sepsis (i.e., sepsis with coexisting severe acute organ dysfunction) (15), other studies have shown no benefit (16). Our prior work suggests that statins do not decrease the risk for severe sepsis or death in patients with CAP (17).…”

Simvastatin and a Plant Galactolipid Protect Animals from Septic Shock by Regulating Oxylipin Mediator Dynamics through the MAPK-cPLA2 Signaling Pathway

“…Results of a randomized, doubleblind, placebo-controlled clinical trial associated simvastatin administration with lower levels of inflammatory cytokines in patients with acute bacterial infections while another study suggested that prior statin therapy may have a role in the primary prevention and management of severe sepsis syndrome (13)(14)(15). Nutritional substrates, including omega-3 PUFA-enriched fish oils and plant sources that contain galactolipids (such as green vegetables and soybeans) have also been shown to modulate pathways involved in the release of inflammatory cytokines or a few types of eicosanoids (16,17).…”

The association between prior statin use and long-term outcomes after critical care admission

“…[21][22][23][24][25][26] Studies have also reported a reduction in attributable mortality from 20% to 3% (P = 0.010). 9 In contrast, our five-year study found no associated mortality-benefit between sepsis-survival and pre-prescription of a statin.…”