The Effects of Statin Medications on Aerobic Exercise Capacity and Training Adaptations

Murlasits, Zsolt; Radák, Zsolt

doi:10.1007/s40279-014-0224-4

Cited by 29 publications

(14 citation statements)

References 96 publications

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“…It has been demonstrated that metformin may attenuate the beneficial effects of exercise on glucose regulation, blood pressure, and blood lipid profile (Malin & Braun, 2016). Similarly, studies suggest that statins may attenuate exercise-induced adaptations as well (Mikus et al, 2013;Murlasits & Radak, 2014), although the opposite effect has also been observed (Meex et al, 2010). As our study was not sufficiently powered for a between-participant statistical comparison of the training adaptations in participants who were taking statins and/or metformin (n=12) vs. the participants who were not (n=4), we cannot determine whether the use of medication may have affected the response to training in the present study.…”

Section: Discussionmentioning

confidence: 99%

A comparison of the health benefits of reduced-exertion high-intensity interval training (REHIT) and moderate-intensity walking in type 2 diabetes patients

Ruffino

Songsorn

Haggett

et al. 2017

Appl. Physiol. Nutr. Metab.

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Section: Discussionmentioning

confidence: 99%

A comparison of the health benefits of reduced-exertion high-intensity interval training (REHIT) and moderate-intensity walking in type 2 diabetes patients

Ruffino

Songsorn

Haggett

et al. 2017

Appl. Physiol. Nutr. Metab.

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“…Second, it is possible that the inclusion of statin‐treated individuals in this study may have impaired our ability to detect improvements in skeletal muscle oxidative capacity and reduction mitochondrial ROS production following RET (Murlasits and Radak ). There were no significant differences in the changes in skeletal muscle oxidative capacity or mitochondrial ROS production in the statin users and non‐users following RET in this study.…”

Section: Discussionmentioning

confidence: 99%

Resistance exercise training and in vitro skeletal muscle oxidative capacity in older adults

et al. 2016

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Whether resistance exercise training (RET) improves skeletal muscle substrate oxidative capacity and reduces mitochondrial production of reactive oxygen species in older adults remains unclear. To address this, 19 older males (≥60 years) were randomized to a RET (n = 11) or to a waitlist control group (n = 8) that remained sedentary for 12 weeks. RET was comprised of three upper body and four lower body movements on resistance machines. One set of 8–12 repetitions to failure of each movement was performed on three nonconsecutive days/week. Improvements in chest press and leg press strength were assessed using a three‐repetition maximum (3 RM). Body composition was assessed via dual energy X‐ray absorptiometry. Muscle biopsies were obtained from the vastus lateralis muscle at baseline and at both 3 weeks and 12 weeks. Palmitate and pyruvate oxidation rates were measured from the 14 CO 2 produced from [1‐14C] palmitic acid and [U‐14C] pyruvate, respectively, during incubation of muscle homogenates. PGC‐1α, TFAM, and PPAR δ levels were quantified using qRT‐PCR. Citrate synthase (CS) and β‐HAD activities were determined spectrophotometrically. Mitochondrial production of reactive oxygen species (ROS) were assessed using the Amplex Red Hydrogen Peroxide/Peroxidase assay. There were no significant changes in body weight or body composition following the intervention. Chest press and leg press strength (3RM) increased ~34% (both P < 0.01) with RET. There were no significant changes in pyruvate or fatty acid oxidation or in the expression of target genes with the intervention. There was a modest increase (P < 0.05) in β HAD activity with RET at 12 weeks but the change in CS enzyme activity was not significant. In addition, there were no significant changes in ROS production in either group following RET. Taken together, the findings of this study suggest that 12 weeks of low volume RET does not increase skeletal muscle oxidative capacity or reduce ROS production in older adults.

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“…Although many patients with HF receive statins, and the use of ET interventions are increasingly incorporated into a patient-centered treatment approach, guidelines do not provide specific recommendations for a combined use strategy or appropriate timing for initiating ET and statin therapy (6,7). …”

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confidence: 99%

Statins and Exercise Training Response in Heart Failure Patients

Kelly

Dunning

Schulte

et al. 2016

JACC: Heart Failure

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OBJECTIVES The aim of this study was to assess for a treatment interaction between statin use and ET response. BACKGROUND Recent data suggest that statins may attenuate exercise training (ET) response, but limited data exist in patients with heart failure (HF). METHODS HF-ACTION (Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training) was a randomized trial of 2,331 patients with chronic HF with ejection fraction ≤35% who were randomized to usual care with or without ET. We evaluated whether there was a treatment interaction between statins and ET response for the change in quality of life and aerobic capacity (peak oxygen consumption and 6-min walk distance) from baseline to 3 months. We also assessed for a treatment interaction among atorvastatin, simvastatin, and pravastatin and change in these endpoints with ET. Multiple linear regression analyses were performed for each endpoint, adjusting for baseline covariates. RESULTS Of 2,331 patients in the HF-ACTION trial, 1,353 (58%) were prescribed statins at baseline. Patients treated with statins were more likely to be older men with ischemic HF etiology but had similar use of renin angiotensin system blockers and beta-blockers. There was no evidence of a treatment interaction between statin use and ET on changes in quality of life or exercise capacity, nor was there evidence of differential association between statin type and ET response for these endpoints (all p values >0.05). CONCLUSIONS In a large chronic HF cohort, there was no evidence of a treatment interaction between statin use and short-term change in aerobic capacity and quality of life with ET. These findings contrast with recent reports of an attenuation in ET response with statins in a different population, highlighting the need for future prospective studies. (Exercise Training Program to Improve Clinical Outcomes in Individuals With Congestive Heart Failure; NCT00047437)

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The Effects of Statin Medications on Aerobic Exercise Capacity and Training Adaptations

Cited by 29 publications

References 96 publications

A comparison of the health benefits of reduced-exertion high-intensity interval training (REHIT) and moderate-intensity walking in type 2 diabetes patients

A comparison of the health benefits of reduced-exertion high-intensity interval training (REHIT) and moderate-intensity walking in type 2 diabetes patients

Resistance exercise training and in vitro skeletal muscle oxidative capacity in older adults

Statins and Exercise Training Response in Heart Failure Patients

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