The effects of static magnetic fields on bone

Zhang, Jian; Ding, Chong; Ren, Li; Zhou, Yimin; Shang, Peng

doi:10.1016/j.pbiomolbio.2014.02.001

Cited by 91 publications

(65 citation statements)

References 61 publications

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“…The positive effects of static magnetic fields on bone tissue engineering are reported by several scholars . Thus, the magnetic properties of nano‐Fe 3 O 4 /PLLA composites developed in this study were explored using quantum interference.…”

Section: Resultsmentioning

confidence: 88%

Fabrication of Fe₃O₄/PLLA composites for use in bone tissue engineering

Pan

Wang

et al. 2016

Polymer Composites

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The aim of this study was to incorporate nanoscale Fe3O4 particles into a poly‐l‐lactide (PLLA) matrix to fabricate a magnetic and biodegradable composite. The physical and osteogenic functions of this material were tested. Injection molding was used to fabricate four nano‐Fe3O4/PLLA composites with Fe3O4 mix ratios of 0%, 20%, 30%, and 40% (w/w). X‐ray diffraction and hysteresis loop tests were performed to evaluate the physical properties of the nano‐Fe3O4/PLLA composites. Tensile strength tests showed that the progressive addition of nano‐Fe3O4 particles to the PLLA matrix results in higher elastic modulus and lower tensile strength. Images from scanning electron microscopy demonstrated that osteoblasts cultured on the 20% nano‐Fe3O4/PLLA surface exhibited abundant filaments, which are a morphologic characteristic of osteoblastic differentiation. These results suggest that the 20% nano‐Fe3O4/PLLA composite used in this study has the potential for future tissue engineering applications. POLYM. COMPOS., 38:2881–2888, 2017. © 2016 Society of Plastics Engineers

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Section: Resultsmentioning

confidence: 88%

Fabrication of Fe₃O₄/PLLA composites for use in bone tissue engineering

Pan

Wang

et al. 2016

Polymer Composites

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“…However, there has been little research concerned with the effects of SMF on osteoclast. For osteoblast, according to the evaluation of matrix mineralization and expression of osteogenic markers under various magnetic flux densities, we found that differentiation potential was dependent on magnetic strength (Zhang et al, 2014a). Our previous results showed that SMF exposure with 0.2 T and 500 nT had a retarded effect, whereas 16 T improved osteogenesis compared to that of the non-stimulated group (Zhang et al, 2014b).…”

Section: Introductionmentioning

confidence: 72%

“…Data shown are mean ± SD. *p < 0.05. bone remodeling promotes osteogenic differentiation (Zhang et al, 2014a), we supposed that osteoclast differentiation was inhibited at the same time. Our results demonstrate that osteoclast formation and TRAP activity were dramatically inhibited under HiMF of 16 T, which enhanced osteogenic differentiation.…”

Section: Discussionmentioning

confidence: 99%

“…Our studies prove that the biological activity of bone cells can be modulated from the perspective of an in vitro system. The approved therapeutic effects of SMF should consider the special microstructure of bone tissue, resulting in electrodynamic interaction of the Hall Effect and piezoelectric effect (Zhang et al, 2014a). This may indirectly yield unexpected cellular responses.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, it is of great significance to systematically elucidate the biological effects and mechanisms of SMFs ranging from hypo, weak, moderate to high. SMF has been studied as a noninvasive physical treatment for promoting bone growth and bone healing, and preventing bone loss (Zhang et al, 2014a). Animal studies have revealed that certain SMFs have a synergistic role in such circumstances as bone surgical invasion (~50 mT) (Yan et al, 1998), ischemic bones (~50 mT) (Xu et al, 2001), ovariectomized rats (180 mT) (Xu et al, 2011), adjuvant arthritis rats (30-80 mT) (Taniguchi et al, 2004), bone fracture (4 mT) (Puricelli et al, 2006) and bone grafts (4 mT) (Puricelli et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

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Regulation of osteoclast differentiation by static magnetic fields

Zhang

Meng

Ding

et al. 2016

Electromagnetic Biology and Medicine

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Static magnetic field (SMF) modulates bone metabolism, but little research is concerned with the effects of SMF on osteoclast. Our previous studies show that osteogenic differentiation is strongly correlated with magnetic strength from hypo (500 nT), weak (geomagnetic field, GMF), moderate (0.2 T) to high (16 T) SMFs. We speculated that the intensity that had positive (16 T) or negative (500 nT and 0.2 T) effects on osteoblast differentiation would inversely influence osteoclast differentiation. To answer this question, we examined the profound effects of SMFs on osteoclast differentiation from pre-osteoclast Raw264.7 cells. Here, we demonstrated that 500 nT and 0.2 T SMFs promoted osteoclast differentiation, formation and resorption, while 16 T had an inhibitory effect. Almost all the osteoclastogenic genes were highly expressed under 500 nT and 0.2 T, including RANK, matrix metalloproteinase 9 (MMP9), V-ATPase, carbonic anhydrase II (Car2) and cathepsin K (CTSK), whereas they were decreased under 16 T. In addition, 16 T disrupted actin formation with remarkably decreased integrin β3 expression. Collectively, these results indicate that osteoclast differentiation could be regulated by altering the intensity of SMF, which is just contrary to that on osteoblast differentiation. Therefore, studies of SMF effects could reveal some parameters that could be used as a physical therapy for various bone disorders.

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A Magnetic Iron Oxide/Polydopamine Coating Can Improve Osteogenesis of 3D‐Printed Porous Titanium Scaffolds with a Static Magnetic Field by Upregulating the TGFβ‐Smads Pathway

Huang

Chang

et al. 2020

Adv Healthcare Materials

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Abstract3D‐printed porous titanium–aluminum–vanadium (Ti6Al4V, pTi) scaffolds offer surgeons a good option for the reconstruction of large bone defects, especially at the load‐bearing sites. However, poor osteogenesis limits its application in clinic. In this study, a new magnetic coating is successfully fabricated by codepositing of Fe3O4 nanoparticles and polydopamine (PDA) on the surface of 3D‐printed pTi scaffolds, which enhances cell attachment, proliferation, and osteogenic differentiation of hBMSCs in vitro and new bone formation of rabbit femoral bone defects in vivo with/without a static magnetic field (SMF). Furthermore, through proteomic analysis, the enhanced osteogenic effect of the magnetic Fe3O4/PDA coating with the SMF is found to be related to upregulate the TGFβ‐Smads signaling pathway. Therefore, this work provides a simple protocol to improve the osteogenesis of 3D‐printed porous pTi scaffolds, which will help their application in clinic.

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The effects of static magnetic fields on bone

Cited by 91 publications

References 61 publications

Fabrication of Fe₃O₄/PLLA composites for use in bone tissue engineering

Fabrication of Fe₃O₄/PLLA composites for use in bone tissue engineering

Regulation of osteoclast differentiation by static magnetic fields

A Magnetic Iron Oxide/Polydopamine Coating Can Improve Osteogenesis of 3D‐Printed Porous Titanium Scaffolds with a Static Magnetic Field by Upregulating the TGFβ‐Smads Pathway

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The effects of static magnetic fields on bone

Cited by 91 publications

References 61 publications

Fabrication of Fe3O4/PLLA composites for use in bone tissue engineering

Fabrication of Fe3O4/PLLA composites for use in bone tissue engineering

Regulation of osteoclast differentiation by static magnetic fields

A Magnetic Iron Oxide/Polydopamine Coating Can Improve Osteogenesis of 3D‐Printed Porous Titanium Scaffolds with a Static Magnetic Field by Upregulating the TGFβ‐Smads Pathway

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Product

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Fabrication of Fe₃O₄/PLLA composites for use in bone tissue engineering

Fabrication of Fe₃O₄/PLLA composites for use in bone tissue engineering