The effects of spirulina on allergic rhinitis

Cingi, Cemal; Dalay, Meltem Conk; Çaklı, Hamdi; Bal, Cengiz

doi:10.1007/s00405-008-0642-8

Cited by 77 publications

(56 citation statements)

References 6 publications

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“…16,17 Based on the available data, we hypothesized that dietary Spirulina supplementation can improve anemia as well as immune function in volunteers .50 years of age with a diagnosis of anemia who were supplemented with Spirulina for 12 weeks. Endpoints included red blood cell (RBC) indices within complete blood count (CBC) and indoleamine 2,3-dioxygenase (IDO) enzyme activity as a sign of immune function 18 at baseline and weeks 6 and 12.…”

Section: Introductionmentioning

confidence: 99%

The effects of Spirulina on anemia and immune function in senior citizens

et al. 2011

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Anemia and immunological dysfunction (i.e. immunosenescence) are commonly found in older subjects and nutritional approaches are sought to counteract these phenomena. Spirulina is a filamentous and multicellular bule-green alga capable of reducing inflammation and also manifesting antioxidant effects. We hypothesized that Spirulina may ameliorate anemia and immunosenescence in senior citizens with a history of anemia. We enrolled 40 volunteers of both sexes with an age of 50 years or older who had no history of major chronic diseases. Participants took a Spirulina supplementation for 12 weeks and were administered comprehensive dietary questionnaires to determine their nutritional regimen during the study. Complete cell count (CCC) and indoleamine 2,3-dioxygenase (IDO) enzyme activity, as a sign of immune function, were determined at baseline and weeks 6 and 12 of supplementation. Thirty study participants completed the entire study and the data obtained were analyzed. Over the 12-week study period, there was a steady increase in average values of mean corpuscular hemoglobin in subjects of both sexes. In addition, mean corpuscular volume and mean corpuscular hemoglobin concentration also increased in male participants. Older women appeared to benefit more rapidly from Spirulina supplements. Similarly, the majority of subjects manifested increased IDO activity and white blood cell count at 6 and 12 weeks of Spirulina supplementation. Spirulina may ameliorate anemia and immunosenescence in older subjects. We encourage large human studies to determine whether this safe supplement could prove beneficial in randomized clinical trials.

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Section: Introductionmentioning

confidence: 99%

The effects of Spirulina on anemia and immune function in senior citizens

et al. 2011

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“…Mao et al (2005) had shown that allergic patients consuming 2,000 mg of Spirulina daily can reduce the production of IL-4 from PHA stimulated PBMCs by 32%. Another double-blind, placebo-controlled study from Turkey evaluating the effectiveness and tolerability of Spirulina for treating patients with allergic rhinitis, Spirulina consumption significantly improved the symptoms and physical findings compared with placebo (p<0.001), including nasal discharge, sneezing, nasal congestion and itching (Cingi et al, 2008).…”

Section: Discussionmentioning

confidence: 98%

The Immunomodulatory Effects of Probiotic Bacteria on Peripheral Blood Mononuclear Cells (Pbmcs) of Allergic Patients

Sheikh¹,

Shalaby²,

Hafez³

et al. 2014

American Journal of Immunology

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Allergic diseases represent major health burden. An allergic reaction is characterized by a disrupted Thelper 1⁄T-helper 2 balance toward a preferential allergen specifically induced TH2 cytokine profile, causing allergic inflammation Probiotic bacteria have various benificial effects in many pathologic situation. Studies have shown that the bacteria present in the intestinal micro flora play a role in the TH1/TH2 balance and its modulation can promote the control of infectious and immune processes. Testing the effects of probiotic bacteria on TH1/TH2 cytokine production by peripheral blood mononuclear cells of allergic patients and control subjects. This study included 24 patients allergic to date pollen and 16 healthy control subjects. PBMC of both groups were separated and cultured for 72 h with date pollen allergen (home-made) in the presence or absence of Lactobacillus rhamnosus ATCC 7469 (Living and dead) and Cphycocyanin (extracted from Spirulina platensis). The cell culture supernatants were collected to measure Interlukin 4 and Interferon gamma by quantitative ELISA. Incubation of PBMCs of allergic patients with living Lactobacillus rhamnosus ATCC 7469 showed marked reduction in IL4 production (median IL4 concentarion = 3.9 pg.) compared to PBMCs callenged with pollen alone (mediam IL4 conentration = 52.6 pg). When PBMC were incubated with living Lactobacillus rhamnosus in absence of allergen significant increase in and IFNγ (median concentration = 42.75 pg.) was obtained, compared to PBMC challenged with allergen alone (median = 22.8 pg). When PBMCs incubated with heat killed Lactobacillus rhamnosus either in presence or absence of the offending allergen, marked reduction in IL4 production was obtained (median = 10.6, 3.6 pg respectively) compared to PBMC incubated with allergen alone (median = 52.6 pg). When PBMCs incubated with dead Lactobacillus rhamnosus, marked increase in IFNγ production was obtained (median = 49 pg) when compared to IFNγ production by PBMC challenged with allergen (median 22.8 pg). PBMCs challenged with PC in the presence or absence of allergen showed marked decrease of IL4 production (median = 19.8, 17 pg respectively) when compared to PBMC incubated with the offending allergen alone (median = 52.6 pg). PBMCs incubated with PC showed significant increase of and IFNγ production (median= 319.6 pg) when compared to PBMC incubated with the offending allergen alone (median = 22.8 pg). Conclusion Lactobacillus rhamnosus ATCC 7469 and C-phycocyanin (extracted from Spirulina platensis) inversed the TH1: TH2 polarization in allergic patients and could be a promissing line of treatmen.

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“…IFN-g production and Natural Killer (NK) cell damage were increased after administration of the microalgal extracts to male volunteers (17). In a recent double blind, placebo controlled study from Turkey evaluating the effectiveness and tolerability of Spirulina for treating patients with allergic rhinitis, Spirulina consumption significantly improved the symptoms and physical findings compared with placebo, including nasal discharge, sneezing, nasal congestion, and itching (36). It is well understood that deficiency of nutrients is responsible for changes in immunity which manifests as changes in production of T-cells, secretory IgA antibody response, cytokines, and NK-cell activity.…”

Section: Spirulina In Allergy and Rhinitismentioning

confidence: 95%

Microalgae and Immune Potential

Raja

Hemaiswarya

2010

Dietary Components and Immune Function

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Key PointsImmunopotentiating activities have been found in whole cells such as bacteria, mush-• rooms, algae, lichens, and higher plants.Microalgae with its long history of food use, easy cultivation, and high nutritional • content make it a valuable source for immunomodulating studies.One of the main components that possesses the immunomodulating activity is the • polysaccharides of the cell. The basic mechanism of the immunostimulatory activity is through the stimulation • of the macrophages and modulation of the complement system.

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The effects of spirulina on allergic rhinitis

Cited by 77 publications

References 6 publications

The effects of Spirulina on anemia and immune function in senior citizens

The effects of Spirulina on anemia and immune function in senior citizens

The Immunomodulatory Effects of Probiotic Bacteria on Peripheral Blood Mononuclear Cells (Pbmcs) of Allergic Patients

Microalgae and Immune Potential

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