The effects of SP110’s associated genes on fresh cavitary pulmonary tuberculosis in Han Chinese population

Abstract

SP110 is a promising anti-Mycobacterium tuberculosis (MTB) gene. To investigate the effects of SP110 and its associated genes, i.e., MYBBP1A and RELA, on pathological progression of MTB infection, an association study with 424 patients of fresh pulmonary tuberculosis (PTB) and 424 healthy controls was performed. Moreover, classification and regression tree and multifactor dimensionality reduction were employed to explore the effects of gene-gene interactions on cavitary PTB. The results indicated that both the heterozygous genotype GC and homozygous genotype CC in rs3809849 had significant effects on the risk of PTB (OR 1.42, 95 % CI 1.06-1.92, p 0.019; OR 1.55, 95 % CI 1.04-2.33, p = 0.033, respectively), and heterozygous genotype CT in rs9061 also had similar effects (OR 1.43, 95 % CI 1.07-1.90, p = 0.014). The rs3809849 and rs9905742 in MYBBP1A were also significantly associated with cavitary PTB (p = 0.00046 and 0.039, respectively), while rs9061 in SP110 had no such association (p = 0.06931) except its significant association with non-cavitary PTB (p = 0.0093). The interaction of MYBBP1A and RELA had significant effect on cavitary PTB (OR 4.24, 95 % CI 1.44-12.49, p = 0.005). These suggest that MYBBP1A instead of SP110 may be a genetic risk factor for cavitary PTB and play important effects on its whole progress.

Certain Polymorphisms in SP110 Gene Confer Susceptibility to Tuberculosis: A Comprehensive Review and Updated Meta-Analysis

“…Two of the ultimately selected articles included data from 4 independent studies 1221. Therefore, 11 articles including 13 studies were included in our meta-analysis, with 9 articles written in English and 2 in Chinese 1218192021223233343536. The flowchart of article sifting is shown in Fig.…”

“…However, these studies yielded inconsistent consequences. Abhimanyu, et al,12 Cai, et al,18 and Cong, et al19 identified the association of SP110 polymorphisms with TB by a case-control design while irrelevant results were found by Png, et al20, Fox, et al21, and Jiang, et al22 Thus, we performed a comprehensive review and updated meta-analysis with more SP110 polymorphisms, articles and subgroup analysis than before, and attempted to verify and offer an accurate and comprehensive understanding of the association between polymorphisms of SP110 gene and human TB susceptibility.…”

Association of cytotoxic T-lymphocyte antigen 4 gene with immune thrombocytopenia in Chinese Han children

“…Five milliliter peripheral blood samples were collected from participants in vacuum tubes containing 5% EDTA. Genomic DNA was isolated and stored using the genomic DNA purification kit (Tiangen Biotech, Beijing, China) according to the instructions [16,17].…”

A Missense Variant rs4645843 in <i>TNF-</i><i>α</i> Gene Is a Risk Factor of Polycystic Ovary Syndrome in the Uygur Population

“…A total of 2 ml anti-coagulated blood was drawn from each subject to extract genomic DNA using the previous methods (Cai et al 2013;Jiang et al 2016). The DNA was stored at −20℃ until it was used.…”