The effects of some K+ channel blockers on scopolamine- or electroconvulsive shock-induced amnesia in mice

İnan, Salim Yalçın; Aksu, Fazilet; Baysal, Firuz

doi:10.1016/s0014-2999(00)00736-6

Cited by 26 publications

(8 citation statements)

References 24 publications

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“…Apamin treatment also accelerates learning during training trials in the Morris water maze, with apamin treated mice requiring fewer trials to learn the location of a hidden platform [66]. Apamin has also been shown to mitigate scopolamine induced memory deficits [67]. These results all suggest that KCa2 blockade facilitates hippocampus-dependent spatial memory encoding.…”

Section: Therapeutic Potential Of Kca2 Modulationmentioning

confidence: 99%

The therapeutic potential of small-conductance KCa2 channels in neurodegenerative and psychiatric diseases

Lam

Coleman

Garing

et al. 2013

Expert Opinion on Therapeutic Targets

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Introduction KCa2 or small-conductance Ca2+-activated K+ channels (SK) are expressed in many areas of the central nervous system where they participate in the regulation of neuronal afterhyperpolarization and excitability, and also serve as negative feedback regulators on the glutamate -NMDA pathway. Areas covered This review focuses on the role of KCa2 channels in learning and memory and their potential as therapeutic targets for Alzheimer’s and Parkinson’s disease, ataxia, schizophrenia, and alcohol dependence. Expert opinion There currently exists relatively solid evidence supporting the use of KCa2 activators for ataxia. Genetic KCa2 channel suppression in deep cerebellar neurons induces ataxia, while KCa2 activators like 1-EBIO, SKA-31 and NS13001 improve motor deficits in mouse models of episodic ataxia (EA) and spinal cerebellar ataxia (SCA). Use of KCa2 activators for ataxia is further supported by a report that riluzole improves ataxia in a small clinical trial. Based on accumulating literature evidence, KCa2 activators further appear attractive for the treatment of alcohol dependence and withdrawal. Regarding Alzheimer’s disease, Parkinson’s and schizophrenia further research, including long-term studies in disease relevant animal models, will be needed to determine whether KCa2 channels constitute valid targets and whether activators or inhibitors would be needed to positively affect disease outcomes.

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Section: Therapeutic Potential Of Kca2 Modulationmentioning

confidence: 99%

The therapeutic potential of small-conductance KCa2 channels in neurodegenerative and psychiatric diseases

Lam

Coleman

Garing

et al. 2013

Expert Opinion on Therapeutic Targets

View full text Add to dashboard Cite

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“…Potassium channels are known to be critical in regulating neuronal excitability and synaptic transmission, and they play an important role in learning and memory . Evidences suggest that Aβ influences cellular homeostasis and neuronal signaling through modulation of K channels functions .…”

Section: Discussionmentioning

confidence: 99%

Using a portable total reflection X‐ray fluorescence system for a multielement analysis of Swiss mice brains with experimental Alzheimer's disease induced by β‐amyloid oligomers

et al. 2019

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Alzheimer's disease (AD) is a progressive and irreversible disorder whose pathological features include β‐amyloid (Aβ) plaques and neuronal and synaptic loss. Metals such as iron, copper, and zinc are increased in the brains of patients with AD. Those metals can interact with Aβ, resulting in the promotion of Aβ deposition and formation of plaque. However, no study analyzing the effects of single injection of Aβ soluble oligomers (AβOs) in the elements' homeostasis in mice was developed. Total reflection X‐ray fluorescence (TXRF) is a multielement analytical technique that can be utilized to identify and quantify trace elements present in a sample at very low concentrations. In this study, in order to evaluate the concentration of metals in brain regions of Swiss mice, three groups of female mice and three of male mice were studied: control, AD10, and AD100. The AD groups received an AβOs intracerebroventricular injection so as to induce experimental AD. Afterwards, a craniotomy was performed, and six brain compartments were dissected and evaluated. TXRF measurements were performed using a portable TXRF system that uses an X‐ray tube with a molybdenum anode and a detector Si‐PIN. It is proved to determine the following elements' concentrations: phosphorus, sulfur, potassium, iron, copper, zinc, and rubidium. Results showed differences in the elemental concentration in some brain regions between AD groups. These alterations suggest that AβOs act quickly, even before the amyloid plaques' formation, explaining cognitive deficits independently of amyloid plaques. This study helped to understand that this modification on elemental concentration can be influenced by AβOs.

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“…It occurs through modulation of ion channel function such as K channels . K channels are known to be critical in regulating neuronal excitability and synaptic transmission, and they play an important role in learning and memory . The clinical hallmark of AD is progressive cognitive impairment.…”

Section: Discussionmentioning

confidence: 99%

Multielement concentration analysis of Swiss mice brains on experimental model of Alzheimer's disease induced by β‐amyloid oligomers

et al. 2017

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Alzheimer's disease (AD) is an insidious, progressive, and irreversible brain disorder that leads to memory loss and severe cognitive decline. However, the discovery that soluble β‐amyloid oligomers are potent central nervous system neurotoxins has led to a new view of AD pathogenesis. Metals, such as zinc, iron, and copper, are all increased in the aged brain, and the contents of those metals in the brain of AD patients are higher than non‐AD people. So, altered homeostasis of metal may result in the development of AD. Total reflection X‐ray fluorescence analysis (TXRF) is a multielement analytical technique, which can be used for elemental trace analysis. In this work, TXRF was used to evaluate the elemental concentration and distribution on mice brain regions. Three groups were studied: control, AD10, and AD100, being the two latter were given a single intracerebroventricular injection of 10 pmol and 100 pmol (β‐amyloid oligomers), respectively, to induce experimental AD. All samples were submitted to acid digestion. The TXRF measurements were performed at the X‐Ray Fluorescence Beamline at Brazilian National Synchrotron Light Laboratory, using a monochromatic beam (11.5 keV) for the excitation. It was possible to determine the concentrations of the following elements: P, S, K, Fe, Cu, and Zn. Results showed differences in the elemental concentration in some brain regions between the AD groups and the control group. Furthermore, the difference in the hypothalamus in AD10 groups, both female and male, suggests an association between AD and changes in these elements. Copyright © 2017 John Wiley & Sons, Ltd.

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The effects of some K+ channel blockers on scopolamine- or electroconvulsive shock-induced amnesia in mice

Cited by 26 publications

References 24 publications

The therapeutic potential of small-conductance KCa2 channels in neurodegenerative and psychiatric diseases

The therapeutic potential of small-conductance KCa2 channels in neurodegenerative and psychiatric diseases

Using a portable total reflection X‐ray fluorescence system for a multielement analysis of Swiss mice brains with experimental Alzheimer's disease induced by β‐amyloid oligomers

Multielement concentration analysis of Swiss mice brains on experimental model of Alzheimer's disease induced by β‐amyloid oligomers

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