The effects of some centrally acting drugs on the glucocorticold induction of hepatic tyrosine transaminase

Tolson, Wiley W.; Colson, Sylvia H.; Umberger, Ernest J.

doi:10.1016/0024-3205(69)90172-6

Life Sciences

1969

DOI: 10.1016/0024-3205(69)90172-6

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The effects of some centrally acting drugs on the glucocorticold induction of hepatic tyrosine transaminase

Wiley W. Tolson

Sylvia H. Colson

Ernest J. Umberger

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1970

1983

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Cited by 3 publications

(1 citation statement)

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“…(10) found chlorpromazine to be a potent inhibitor of the hexobarbital-metabolizing enzyme systems in the perfused rat liver. I n addition, Tdson et d. (11) reported that treatment with chlor-promazime or imipramine pot en t ia ted cortisol induction of hepatic tyrosine transaminase activity. Kato et al (12) observed that imipramine exhibited a strong inhibitory action on the in vivo and in vitro metabolism of barbiturates, carisoprodol, and strychnine.…”

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Effects of Various Drugs on the Uterotropic Response to Mestranol and Norethynodrel in the Rat

Calhoun

Tolson

Schrogie

1971

Experimental Biology and Medicine

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Mestranol and norethynodrel are synthetic steroids commonly used in oral contraceptive drug formulations. The efficacy of such preparations may be affected by other drugs which influence the hormonal activity of these agents.The present study utilizes the induction phase response of the rat uterus to a single dose of hormone as a method of evaluating possible interactions between mestranol, norethynodrel, and various other drugs.MateriaZs and Methods. Immature female rats (19 days old) were obtained from the Holtzman Colony, Madison, Wisconsin. The rats were caged individually and receivedPurina laboratory chow and water ad Zibiturn. Animal quarters were kept at a constant temperature (24') and on a controlled constant lighting schedule (12 hr dark, 12 hr light).Drugs were dissolved in saline with the exception of phenylbutazone and diphenylhydantoin, which were suspended in carboxymethylcellulose medium. Dru.gs were administered intraperitoneally twice daily for 3 days at the following doses: phenobarbital, 3 7 mgJkg; SKF 525A (Proadifen) 40 mg/kg; tolbutamide, 125 mg/kg ; chlorpromazine, 5 mg/kg; imipramine, 8 mg/kg: paraaminosalicylic acid, 3 mg/kg ; diphenylhydantoin, 12 5 mg/kg ; phenylbutazone, 60 mg/kg ; scopolamine hydrobromide, 0.5 mg/kg. The total volume per dose was 0.2 ml .Mestranol and norethynodrel were dissolved in corn oil and administered in a volume of 0.2 ml by oral intubation 18 hr following the last pretreatment dose.

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confidence: 99%

Effects of Various Drugs on the Uterotropic Response to Mestranol and Norethynodrel in the Rat

Calhoun

Tolson

Schrogie

1971

Experimental Biology and Medicine

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Inhibition of casein hydrolysate induction and insulin induction of hepatic tyrosine transaminase in the rat

1970

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Influence of chlorpromazine, reserpine, and lithium carbonate upon the induction of the tyrosine aminotransferase (TAT) in the rat liver

Kröger

Grätz

1983

General Pharmacology: The Vascular System

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The effects of some centrally acting drugs on the glucocorticold induction of hepatic tyrosine transaminase

Cited by 3 publications

References 15 publications

Effects of Various Drugs on the Uterotropic Response to Mestranol and Norethynodrel in the Rat

Effects of Various Drugs on the Uterotropic Response to Mestranol and Norethynodrel in the Rat

Inhibition of casein hydrolysate induction and insulin induction of hepatic tyrosine transaminase in the rat

Influence of chlorpromazine, reserpine, and lithium carbonate upon the induction of the tyrosine aminotransferase (TAT) in the rat liver

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