The Effects of Soman on Human Isolated Uterine Arteries

Abstract

<jats:p> 1 The effects of soman on the resting contractile tension of human uterine arteries, and on contractions of these arteries to vasoactive agents were investigated. </jats:p><jats:p> 2 Soman did not alter the resting tension of helically-cut strips of human uterine arteries. </jats:p><jats:p> 3 Soman did not alter concentration-response curves of the strips to noradrenaline, serotonin, potassium chloride or histamine. </jats:p><jats:p> 4 Soman increased contractile tension of human uterine artery strips to subsequently added 1 μM noradrenaline. </jats:p><jats:p> 5 It is possible that this enhancement may be involved in decreased regional blood flow following soman administration. </jats:p>