The Effects of Sodium Antimony Tartrate on the Myocardium

Honey, M

doi:10.1136/hrt.22.5.601

Cited by 27 publications

(13 citation statements)

References 21 publications

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“…Electrocardiographic abnormalities have been consistently recorded during treatment with antimonials (Honey, 1960;Davis, 1961;Sommers & Rosanelli 1962;Surawicz, 1970;Sapire & Silverman, 1970;Stemmer, 1976). In this study of sodium stibogluconate the drug did not appear to influence PR interval, QRS duration or R wave height.…”

Section: Ambulatory Monitoringmentioning

confidence: 67%

“…In agreement with others however (Dempsey, 1965;Kaplan et al, 1978) (Coumel et al, 1980;Schwartz, 1980). This is of great importance during antimonial therapy as QT prolongation, malignant ventricular arrhythmias and even sudden death have been reported (Honey, 1960;Davis, 1961;Sommers & Rosanelli, 1962;Surawicz, 1970;Stemmer, 1976). Interestingly the effect on QT interval is not uniform (Davis 1961;Sommers & Rosanelli, 1962 (Schwartz, 1980).…”

Section: Ambulatory Monitoringmentioning

confidence: 99%

“…In dogs it reduces myocardial contractile force (BrombergerBarnea & Stephens, 1965) and in man the trivalent antimonials have been associated with a variety of serious cardiac side-effects including hypotension, bradycardia, ventricular tachycardia, syncope, electrocardiographic changes (deformed P waves, QT prolongation and reduced T wave amplitude) and occasionally sudden death (Honey, 1960;Davis, 1961;Sommers & Rosanelli, 1962;Surawicz, 1970;Sapire & Silverman, 1970;Stemmer, 1976). Sodium stibogluconate, a pentavalent antimonial, was introduced as a safer alternative (Editorial, 1961;Stemmer, 1976) and has now assumed a place of great importance in the treatment of Kala-azar and potentially metastatic cutaneous leishmaniasis due to Leishmania braziliensis (Maegraith, 1980;MansonBahr, 1982).…”

Section: Introductionmentioning

confidence: 99%

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Cardiac effects of sodium stibogluconate.

Henderson¹,

Jolliffe²

1985

Brit J Clinical Pharma

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1 Sodium stibogluconate although potentially cardiotoxic is the drug of choice for Kalaazar and cutaneous leishmaniasis due to Leishmania braziliensis. Increasing use of this drug in the British Army has necessitated a formal evaluation of its cardiac side-effects. 2 Consequently a detailed study of the cardiac effects of sodium stibogluconate was undertaken in 22 male soldiers using for the first time modern non-invasive techniques. 3 Intravenous sodium stibogluconate 600 mg daily for 10 days did not affect blood pressure, heart rate, left ventricular contractile function or rhythm. Electrocardiography showed a reversible reduction of T wave amplitude.

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Section: Ambulatory Monitoringmentioning

confidence: 67%

Section: Ambulatory Monitoringmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cardiac effects of sodium stibogluconate.

Henderson¹,

Jolliffe²

1985

Brit J Clinical Pharma

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“…Tartar emetic, as other antimony compounds, is a drug that can induce cardiotoxicity (Honey, 1960;Thakur, 1998;Kuryshev et al, 2006). In this case, the most important ECG abnormalities are ST segment inversion, QT interval prolongation, and therefore 'torsades de points' and sudden heart attack (Lacerda-Junior et al, 1965;Chulay et al, 1985).…”

Section: Discussionmentioning

confidence: 99%

Reduced cardiovascular alterations of tartar emetic administered in long-circulating liposomes in rats

et al. 2010

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Trivalent antimonial drugs, including tartar emetic (TA), are known to induce important cardiotoxicity observed by electrocardiographic abnormalities. Liposome encapsulation was found to reduce the overall acute toxicity of TA. The present work investigated the cardiovascular parameters alterations of rats submitted to the treatment with free and encapsulated TA in long-circulating liposomes. Liposomes were made using lipids DSPC, DSPE-PEG and cholesterol. The cardiovascular signals, electrocardiogram (ECG) and arterial blood pressure (AP), were recorded from anaesthetized Wistar rats after intravenous (IV) administration of a single specially high dose (17 mg/kg) of TA in liposomes and in free form. The IV administration of TA solution caused significant increase of QT interval of ECG and significant reduction of AP when compared to the control group. These alterations were not observed when liposomes TA were administered and the profile of ECG and AP data was quite similar to the control groups. In conclusion, a liposomal formulation of TA showed a reduced cardiotoxic profile for TA when compared to the free form.

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“…These alterations are similar to the findings with arsenic poisoning. The myocardial toxicity of both the older and newer forms of antimonials has been the subject of several reports (379)(380)(381).…”

Section: Metallic Compoundsmentioning

confidence: 99%

Drug-induced cardiomyopathies

Wenzel

1967

Journal of Pharmaceutical Sciences

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The Effects of Sodium Antimony Tartrate on the Myocardium

Cited by 27 publications

References 21 publications

Cardiac effects of sodium stibogluconate.

Cardiac effects of sodium stibogluconate.

Reduced cardiovascular alterations of tartar emetic administered in long-circulating liposomes in rats

Drug-induced cardiomyopathies

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