2022
DOI: 10.1038/s41398-022-02178-4
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The effects of social isolation stress and discrimination on mental health

Abstract: Social isolation and discrimination are growing public health concerns associated with poor physical and mental health. They are risk factors for increased morbidity and mortality and reduced quality of life. Despite their detrimental effects on health, there is a lack of knowledge regarding translation across the domains of experimental research, clinical studies, and real-life applications. Here, we review and synthesize evidence from basic research in animals and humans to clinical translation and intervent… Show more

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Cited by 45 publications
(23 citation statements)
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“…For example, employment and financial insecurity are well-known sources of chronic stress [ 97 , 98 ]. Similarly, social isolation and loneliness are societal challenges that can create ongoing background stress [ 78 , 79 , 99 ] that may weaken emotion regulation capacities as well as reduce perceived social coping resources.…”
Section: Applications Of a Stress Context Vulnerability Model Of Proc...mentioning
confidence: 99%
“…For example, employment and financial insecurity are well-known sources of chronic stress [ 97 , 98 ]. Similarly, social isolation and loneliness are societal challenges that can create ongoing background stress [ 78 , 79 , 99 ] that may weaken emotion regulation capacities as well as reduce perceived social coping resources.…”
Section: Applications Of a Stress Context Vulnerability Model Of Proc...mentioning
confidence: 99%
“…Social interactions have undergone profound alterations as a result of the pandemic [ 39 ]. Previous research has shown that the COVID-19 pandemic has caused excessive anxiety in the neighborhood; as a result, individuals attempt to keep their distance from one another in the streets and public areas to prevent spreading the virus to their families.…”
Section: Discussionmentioning
confidence: 99%
“…Social distancing not only caused a direct reduction in physical activity but also had a negative effect on mental health during the pandemic. Multiple longitudinal studies showed that individuals who experienced social isolation and loneliness tended to have more unhealthy behaviors ( 29 31 ), such as smoking and alcohol abuse, that may further be associated with the progression of CVD. Evidence from a large US prospective cohort study suggested social isolation and loneliness in the era of COVID-19 were independently associated with a modestly higher risk of CVD ( 32 ).…”
Section: Discussionmentioning
confidence: 99%