The Effects of Smoke Carcinogens on Bone

Yan, Carol H.; Avadhani, Narayan G.; Iqbal, Jameel

doi:10.1007/s11914-011-0068-x

Cited by 39 publications

(15 citation statements)

References 37 publications

(37 reference statements)

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“…Yan and colleagues () have reported a negative influence of smoking on BMD. Although our sample consisted of heavy smokers (on average 30.6 pack‐years), we were unable to find a negative correlation between smoking and BMD.…”

Section: Discussionmentioning

confidence: 99%

Markers of Bone Resorption and Formation During Abstinence in Male Alcoholic Patients

Malík

Gasser

Moncayo

et al. 2012

Alcoholism Clin & Exp Res

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Section: Discussionmentioning

confidence: 99%

Markers of Bone Resorption and Formation During Abstinence in Male Alcoholic Patients

Malík

Gasser

Moncayo

et al. 2012

Alcoholism Clin & Exp Res

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“…Nutrient deficiency impairs fetal bone development. 17,26,27) In a prospective birth cohort study that aimed to evaluate the effect of parental smoking during pregnancy on the bone mass of 7,121 children at 10 years of age, maternal smoking was associated with an increased risk of total body less head, spine BMC, bone area, and BMD in girls; however, the relationship was not significant for boys. 25 large birth cohort study of 6,718 children in Northern Finland showed that MSDP was directly associated with an increased risk of in-hospital-treated fractures at pre-school age (RR, 1.83fold; 95% CI, 1.06-3.02; P=0.022).…”

Section: Discussionmentioning

confidence: 99%

Association between maternal smoking during pregnancy and risk of bone fractures in offspring: a systematic review and meta-analysis

2021

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This study aimed to investigate the effect of maternal smoking during pregnancy (MSDP) on the risk of bone fractures in the offspring through a systematic review and meta-analysis. The PubMed, Web of Science, and Scopus databases were systematically searched for relevant articles published through July 2019. According to heterogeneity, the pooled risk ratio (RR) and odds ratio (OR) and their corresponding 95% confidence interval (CI) were obtained using fixed or random effects models. The heterogeneity and quality of the included studies were assessed by the I-squared (I 2) statistic and the Newcastle-Ottawa scale, respectively. Sensitivity analyses were performed to test the effect of MSDP misclassification on the results. The review of 842 search records yielded 5 studies including 8,746 mother-child pairs that were included in the meta-analysis. Pooling adjusted effect measures showed that MSDP was not associated with a later risk of bone fractures in the offspring (pooled RR, 1.15; 95% CI, 0.84-1.58; I 2 =66.8%; P=0.049). After the adjustment for misclassification, MSDP may be associated with a 27% increased risk of bone fracture (pooled OR, 1.27; 95% CI, 1.00-1.62; I 2 =0%; P=0.537). After the adjustment for misclassification, MSDP is associated with an increased risk of bone fractures among children whose mothers smoked during pregnancy.

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“…In preclinical studies, tobacco smoking has been associated with increased intervertebral disc degeneration, decreased bone mineral density and reduced microstructural integrity of cerebral white matter. 9,11,31 Furthermore, nicotine treatment results in stenosis of and a decrease in the number of vascular bulbs, enlargement of vascular endothelial cells, and reduced blood flow.…”

Section: Discussionmentioning

confidence: 99%

Predicting the minimum clinically important difference in patients undergoing surgery for the treatment of degenerative cervical myelopathy

Tetreault

Wilson

Kotter

et al. 2016

FOC

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OBJECTIVE The minimum clinically important difference (MCID) is defined as the minimum change in a measurement that a patient would identify as beneficial. Before undergoing surgery, patients are likely to inquire about the ultimate goals of the operation and of their chances of experiencing meaningful improvements. The objective of this study was to define significant predictors of achieving an MCID on the modified Japanese Orthopaedic Association (mJOA) scale at 2 years following surgery for the treatment of degenerative cervical myelopathy (DCM). METHODS Seven hundred fifty-seven patients were prospectively enrolled in either the AOSpine North America or International study at 26 global sites. Fourteen patients had a perfect preoperative mJOA score of 18 and were excluded from this analysis (n = 743). Data were collected for each participating subject, including demographic information, symptomatology, medical history, causative pathology, and functional impairment. Univariate log-binominal regression analyses were conducted to evaluate the association between preoperative clinical factors and achieving an MCID on the mJOA scale. Modified Poisson regression using robust error variances was used to create the final multivariate model and compute the relative risk for each predictor. RESULTS The sample consisted of 463 men (62.31%) and 280 women (37.69%), with an average age of 56.48 ± 11.85 years. At 2 years following surgery, patients exhibited a mean change in functional status of 2.71 ± 2.89 points on the mJOA scale. Of the 687 patients with available follow-up data, 481 (70.01%) exhibited meaningful gains on the mJOA scale, whereas 206 (29.98%) failed to achieve an MCID. Based on univariate analysis, significant predictors of achieving the MCID on the mJOA scale were younger age; female sex; shorter duration of symptoms; nonsmoking status; a lower comorbidity score and absence of cardiovascular disease; and absence of upgoing plantar responses, lower-limb spasticity, and broad-based unstable gait. The final model included age (relative risk [RR] 0.924, p < 0.0001), smoking status (RR 0.837, p = 0.0043), broad-based unstable gait (RR 0.869, p = 0.0036), and duration of symptoms (RR 0.943, p = 0.0003). CONCLUSIONS In this large multinational prospective cohort, 70% of patients treated surgically for DCM exhibited a meaningful functional gain on the mJOA scale. The key predictors of achieving an MCID on the mJOA scale were younger age, shorter duration of symptoms, nonsmoking status, and lack of significant gait impairment.

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The Effects of Smoke Carcinogens on Bone

Cited by 39 publications

References 37 publications

Markers of Bone Resorption and Formation During Abstinence in Male Alcoholic Patients

Markers of Bone Resorption and Formation During Abstinence in Male Alcoholic Patients

Association between maternal smoking during pregnancy and risk of bone fractures in offspring: a systematic review and meta-analysis

Predicting the minimum clinically important difference in patients undergoing surgery for the treatment of degenerative cervical myelopathy

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