The effects of small molecule organic additives on the self-assembly and rheology of betaine wormlike micellar fluids

McCoy, Thomas M.; King, Joshua P.; Moore, Jackson E.; Kelleppan, Veena T.; Соколова, Aнна; Campo, Liliana de; Manohar, Madhura; Darwish, Tamim A.; Tabor, Rico F.

doi:10.1016/j.jcis.2018.09.046

Cited by 55 publications

(32 citation statements)

References 84 publications

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“…According to Figures 3C,D, as the incorporated betaine increased, the cumulative release percentage of betaine decreased, but the cumulative release amounts of betaine increased. This could be due to the strong intermolecular electrostatic interactions between zwitterionic betaine pairs and between betaine and collagen matrix, which could tighten the sponge networks and thus impose an additional barrier for releasing betaine from the sponge (Zheng et al, 2018;McCoy et al, 2019).…”

Section: Characterization Of Bet@colmentioning

confidence: 99%

Highly Water-Preserving Zwitterionic Betaine-Incorporated Collagen Sponges With Anti-oxidation and Anti-inflammation for Wound Regeneration

Chen

Huang

et al. 2020

Front. Cell Dev. Biol.

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A core problem in wound healing-with both fundamental and technological significance-concerns the rational design of bioactive and moist microenvironments. Here, we design a new class of zwitterionic betaine-incorporated collagen sponges (BET@COL) with integrated anti-oxidation and anti-inflammatory properties for promoting wound healing in a full-thickness wound model. The presence of zwitterionic betaine in a 3D network structure of collagen enables tightly bound and locked water molecules inside sponges via ionic solvation and confinement effect, while the integration of this amino acid also empowers the sponge with anti-oxidation and anti-inflammatory functions. In vitro results demonstrated that BET@COL collagen sponges strongly preserved water content up to 33.78 ± 0.78% at the 80th min at 37 • C (only 0.44 ± 0.18% in control), and also exhibited high cell biocompatibility. Further, BET@COL collagen sponges with different betaine contents were applied to a full-thickness cutaneous wound model in mice, followed by a systematical evaluation and comparison of the effect of preserved water on wound healing efficiency in vivo. The optimal BET@COL collagen sponges were able to maintain high water content (e.g., moist microenvironment), suppress oxidative stress, improve antiinflammation, all of which impose synergetic healing effects to promote wound closure, granulation formation, re-epithelization, collagen deposition and angiogenesis. This work demonstrates a new material as a promising candidate for wound dressing.

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Section: Characterization Of Bet@colmentioning

confidence: 99%

Highly Water-Preserving Zwitterionic Betaine-Incorporated Collagen Sponges With Anti-oxidation and Anti-inflammation for Wound Regeneration

Chen

Huang

et al. 2020

Front. Cell Dev. Biol.

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“…It should be noted that the 2 wt. % OB solution, even without SDS, possesses viscoelastic properties indicating to the presence of WLMs [23,24]. At the same time, the solution of 0.1 wt.…”

Section: Viscoelasticity Of Wlm Network With Embedded Nanoclay Partimentioning

confidence: 88%

“…For the preparation of the WLM hydrogel, the nontoxic zwitterionic surfactant oleylamidopropyldimethylcarboxybetaine (OB) was used. This surfactant can make transient network of long WLMs, as was shown recently [23,24]. Betaines demonstrate a strong synergism when mixed with anionic surfactant [25], in particular, sodium dodecyl sulfate (SDS) [26].…”

Section: Introductionmentioning

confidence: 84%

Injectable ultra-soft hydrogel with natural nanoclay

Молчанов¹,

Efremova²,

Kiseleva³

et al. 2019

Nanosystems: Phys. Chem. Math.

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Soft hydrogels based on a transient network of wormlike surfactant micelles containing bentonite nanoclay tactoids as physical cross-links were developed. The network was composed of mixed micelles of nontoxic zwitterionic surfactant oleylamidopropyldimethylcarboxybetaine and an anionic surfactant sodium dodecyl sulfate. It was demonstrated that before nanoclay addition the solution has pronounced viscoelastic properties with zero-shear viscosity of 100 Pa s and plateau modulus around 7 Pa, which were attributed to the formation of an entangled micellar network. The solution demonstrated pronounced shear thinning behavior provided by the elongation of wormlike micellar chains in flow direction. Upon addition of non-exfoliated nanoclay particles, the zero-shear viscosity increases by an order of magnitude, while the useful property of shear-induced thinning is retained. Oscillation amplitude tests show that viscoelastic fluid becomes hydrogel upon addition of nanoclay, because elastic response was observed even at large stress amplitudes. This behavior was attributed to the formation of nanoclaywormlike micelles junctions. Prepared soft hydrogel is a promising candidate for injection applications, because of its self-assembled structure providing pronounced shear-thinning behavior and fast recovery of rheological properties at rest. In this nanocomposite material, nanoclay tactoids strengthen the hydrogels and can serve as reservoirs for the delivery of various substances.

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“…Zwitterionic surfactants are, to an extent, self-screening, which allows them to pack more densely at interfaces while also having high aqueous solubilities. [51][52][53][54][55] In the case of OAPB, it is likely that GO experiences attractive interactions with the positively charged ammonium in the head-group, especially in cases where the carboxyl group is protonated. OAPB molecules are thus going to have high affinities for the GO surfaces, and render the sheets hydrophobic.…”

Section: Go/zwitterionic Surfactant Systemsmentioning

confidence: 99%

Spontaneous surface adsorption of aqueous graphene oxide by synergy with surfactants

McCoy

Armstrong

Moore

et al. 2022

Phys. Chem. Chem. Phys.

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The effects of small molecule organic additives on the self-assembly and rheology of betaine wormlike micellar fluids

Cited by 55 publications

References 84 publications

Highly Water-Preserving Zwitterionic Betaine-Incorporated Collagen Sponges With Anti-oxidation and Anti-inflammation for Wound Regeneration

Highly Water-Preserving Zwitterionic Betaine-Incorporated Collagen Sponges With Anti-oxidation and Anti-inflammation for Wound Regeneration

Injectable ultra-soft hydrogel with natural nanoclay

Spontaneous surface adsorption of aqueous graphene oxide by synergy with surfactants

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