The effects of slide cohesion on impulse-wave formation

Meng, Zhenzhu; Ancey, Christophe

doi:10.1007/s00348-019-2800-8

Cited by 10 publications

(12 citation statements)

References 37 publications

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“…As with Islam et al [42], we observed that the hydrogels based on Carbopol ® Ultrez TM 10 and 30 were shear-thinning fluids characterized by a low degree of thixotropy and the presence of yield stress (Figure 5). The flow curves with increasing and decreasing shear rates were best described by the Herschel-Bulkley model, which was also confirmed by Meng et al [25,62]. At T = 25 • C, the curves were very close to each other, whereas at T = 32 Low yield stress values of the H1-INS formulation suggest a lighter texture, easier melting of the hydrogel on the skin surface, and a higher insulin diffusion coefficient at the application site, which was confirmed in the pharmaceutical availability study.…”

Section: Discussionsupporting

confidence: 83%

“…As with Islam et al [ 42 ], we observed that the hydrogels based on Carbopol ® Ultrez TM 10 and 30 were shear-thinning fluids characterized by a low degree of thixotropy and the presence of yield stress ( Figure 5 ). The flow curves with increasing and decreasing shear rates were best described by the Herschel–Bulkley model, which was also confirmed by Meng et al [ 25 , 62 ]. At T = 25 °C, the curves were very close to each other, whereas at T = 32 °C, the hysteresis area increased slightly (H1-INS 10.66 Pa/s vs. 16.68 Pa/s; H2-INS 31.40 Pa/s vs. 39.09 Pa/s).…”

Section: Discussionsupporting

confidence: 81%

“…It was found that Carbopols ensured high pharmaceutical availability of the drug substance [ 25 ]. In total, 70% of insulin was released from the Carbopol ® Ultrez TM 10 hydrogel matrix, and 65% was released from the Carbopol ® Ultrez TM 30 hydrogel within 3 h. In comparison, 75% of insulin was released from the methyl cellulose-based hydrogel after 9 h, and 60% was released from the glycerol ointment after 6 h. The shorter time of insulin release from the H1 and the H2 matrices resulted from their chemical structure.…”

Section: Discussionmentioning

confidence: 99%

“…Hydrogel preparations were prepared er the requirements of the Polish Pharmacopoeia XI [ 24 ], according to the formula provided in Table 1 . Triethanolamine was used for neutralizing carboxyl groups and spatial cross-linking of Carbopol ® Ultrez™ 10 (H1) and Carbopol ® Ultrez™ 30 (H2) [ 25 ]. The formulation pH was neutral.…”

Section: Methodsmentioning

confidence: 99%

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Pre-Formulation Studies: Physicochemical Characteristics and In Vitro Release Kinetics of Insulin from Selected Hydrogels

et al. 2021

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Insulin loaded to the polymer network of hydrogels may affect the speed and the quality of wound healing in diabetic patients. The aim of our research was to develop a formulation of insulin that could be applied to the skin. We chose hydrogels commonly used for pharmaceutical compounding, which can provide a form of therapy available to every patient. We prepared different gel formulations using Carbopol® UltrezTM 10, Carbopol® UltrezTM 30, methyl cellulose, and glycerin ointment. The hormone concentration was 1 mg/g of the hydrogel. We assessed the influence of model hydrogels on the pharmaceutical availability of insulin in vitro, and we examined the rheological and the texture parameters of the prepared formulations. Based on spectroscopic methods, we evaluated the influence of model hydrogels on secondary and tertiary structures of insulin. The analysis of rheograms showed that hydrogels are typical of shear-thinning non-Newtonian thixotropic fluids. Insulin release from the formulations occurs in a prolonged manner, providing a longer duration of action of the hormone. The stability of insulin in hydrogels was confirmed. The presence of model hydrogel carriers affects the secondary and the tertiary structures of insulin. The obtained results indicate that hydrogels are promising carriers in the treatment of diabetic foot ulcers. The most effective treatment can be achieved with a methyl cellulose-based insulin preparation.

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Section: Discussionsupporting

confidence: 83%

“…As with Islam et al [ 42 ], we observed that the hydrogels based on Carbopol ® Ultrez TM 10 and 30 were shear-thinning fluids characterized by a low degree of thixotropy and the presence of yield stress ( Figure 5 ). The flow curves with increasing and decreasing shear rates were best described by the Herschel–Bulkley model, which was also confirmed by Meng et al [ 25 , 62 ]. At T = 25 °C, the curves were very close to each other, whereas at T = 32 °C, the hysteresis area increased slightly (H1-INS 10.66 Pa/s vs. 16.68 Pa/s; H2-INS 31.40 Pa/s vs. 39.09 Pa/s).…”

Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Pre-Formulation Studies: Physicochemical Characteristics and In Vitro Release Kinetics of Insulin from Selected Hydrogels

et al. 2021

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“…Researchers have conducted experiments using physical models that try to reproduce the physical processes of impulse waves generated by subaerial landslides. They have simplified water geometry by using 2D flumes or 3D basins and idealized the sliding masses as rigid blocks [4][5][6][7][8], granular solids [9][10][11][12][13][14], or viscoplastic fluids [15,16]. Based on reliable experimental data, a number of empirical or semi-empirical equations have been established, either by combining regression techniques with dimensional analysis [11,[17][18][19] or by a scaling analysis of governing equations [20,21].…”

Section: Introductionmentioning

confidence: 99%

Using a Data Driven Approach to Predict Waves Generated by Gravity Driven Mass Flows

Meng

Ancey

2020

Water

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When colossal gravity-driven mass flows enter a body of water, they may generate waves which can have destructive consequences on coastal areas. A number of empirical equations in the form of power functions of several dimensionless groups have been developed to predict wave characteristics. However, in some complex cases (for instance, when the mass striking the water is made up of varied slide materials), fitting an empirical equation with a fixed form to the experimental data may be problematic. In contrast to previous empirical equations that specified the mathematical operators in advance, we developed a purely data-driven approach which relies on datasets and does not need any assumptions about functional form or physical constraints. Experiments were carried out using Carbopol Ultrez 10 (a viscoplastic polymeric gel) and polymer–water balls. We selected an artificial neural network model as an example of a data-driven approach to predicting wave characteristics. We first validated the model by comparing it with best-fit empirical equations. Then, we applied the proposed model to two scenarios which run into difficulty when modeled using those empirical equations: (i) predicting wave features from subaerial landslide parameters at their initial stage (with the mass beginning to move down the slope) rather than from the parameters at impact; and (ii) predicting waves generated by different slide materials, specifically, viscoplastic slides, granular slides, and viscoplastic–granular mixtures. The method proposed here can easily be updated when new parameters or constraints are introduced into the model.

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Numerical simulation of potential impulse waves generated by the Mogu rock landslide at varying water levels in the Lianghekou Reservoir, China

Chen,

Xu,

Zhang

et al. 2024

Landslides

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Reservoir impoundment and water level fluctuations often trigger landslides and their secondary disasters, such as potential impulse waves, posing a serious threat to the safety of people along the reservoir and dam areas, causing economic losses and even catastrophic consequences. This study delves into a comprehensive field investigation and monitoring of the engineering geological conditions and deformation mechanisms the Mogu rock landslide. Impoundment is identified as the primary factor inducing slope deformation, with the cumulative displacement of the sliding body showing no signs of convergence, indicating potential instability. By coupling the elasto-visco-plasticity model and the RNG turbulence model in FLOW3D, an actual surge disaster near the Lianghekou Reservoir dam area is replicated to validate the reliability of the numerical method. Building upon this, a three-dimensional model is established to calculate potential impulse waves generated by the Mogu rock landslide, and the risk to the dam is evaluated. Under varying water level conditions, the simulated heights of impulse waves do not surpass the dam elevation, demonstrating a satisfactory safety margin. Given the inherent danger of landslide-induced wave disasters, continuous attention is warranted, and preventive measures and suggestions are proposed to address these concerns. Additionally, the study explores the contributions of water level fluctuations to the primary wave height, the maximum run-up on the opposite bank and the dam, and the attenuation rate of wave height along the river channel. The results provide significant reference values for the early warning and prevention of comparable reservoir landslides and potential landslide-induced waves worldwide.

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The effects of slide cohesion on impulse-wave formation

Cited by 10 publications

References 37 publications

Pre-Formulation Studies: Physicochemical Characteristics and In Vitro Release Kinetics of Insulin from Selected Hydrogels

Pre-Formulation Studies: Physicochemical Characteristics and In Vitro Release Kinetics of Insulin from Selected Hydrogels

Using a Data Driven Approach to Predict Waves Generated by Gravity Driven Mass Flows

Numerical simulation of potential impulse waves generated by the Mogu rock landslide at varying water levels in the Lianghekou Reservoir, China

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