The effects of sleep deprivation on symptoms of psychopathology in healthy adults

Kahn-Greene, Ellen T.; Killgore, Desiree B.; Kamimori, Gary H.; Balkin, Thomas J.; Killgore, William D.S.

doi:10.1016/j.sleep.2006.08.007

Cited by 270 publications

(179 citation statements)

References 43 publications

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“…Indeed, our post-hoc regression analysis further confirmed that sleep quality was not a significant predictor of paranoia. This is surprising as several studies have reported links between a range of sleep disturbances and paranoia (Kahn-Greene et al, 2007;Sheaves et al, 2016;Reeve et al, 2017).…”

Section: Sleep Quality and Paranoiamentioning

confidence: 90%

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Sleep quality and paranoia: The role of alexithymia, negative emotions and perceptual anomalies

Rehman

Gumley

Biello

2018

Psychiatry Research

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A B S T R A C TRecent evidence suggests that sleep problems are associated with psychotic like experiences including paranoia. However, the mechanisms underpinning this association are not well understood and thus studies modelling hypothesised mediating factors are required. Alexithymia, the inability to recognise and describe emotions within the self may be an important candidate. In two separate studies we sought to investigate factors mediating the relationship between sleep quality and paranoia using a cross-sectional design. Healthy volunteers without a mental health diagnosis were recruited (study 1, N = 401, study 2, N = 402). Participants completed a series of measures assessing paranoia, negative emotions, alexithymia and perceptual anomalies in an online survey. In study 1, regression and mediation analyses showed that the relationship between sleep quality and paranoia was partially mediated by alexithymia, perceptual anomalies and negative affect. In contrast, study 2 found that the relationship between sleep quality and paranoia was fully mediated by negative affect, alexithymia and perceptual anomalies. The link between sleep quality and paranoia is unclear and reasons for discrepant results are discussed. Novel findings in this study include the link between alexithymia and paranoia.

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Section: Sleep Quality and Paranoiamentioning

confidence: 90%

“…At the non-clinical level, sleep loss in healthy individuals leads to an increase in paranoid thoughts (Kahn-Greene et al, 2007;Reeve et al, 2017). Another study administered the Oxford Sleep Survey which includes questions on sleep and psychotic like experiences (PLE's) to over 1000 students.…”

Section: Introductionmentioning

confidence: 99%

Sleep quality and paranoia: The role of alexithymia, negative emotions and perceptual anomalies

Rehman

Gumley

Biello

2018

Psychiatry Research

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“…Fifty-five hours of sleep loss induced intense frustration and aggression, deterioration in interpersonal relations [120], as well as an increase in the subjective perception of affective symptoms of psychopathology (anxiety, depression, mania, insanity) [121]. Survey studies conducted on male teenagers revealed a correlation between sleep deficiency and elevated aggression [122].…”

Section: Changes In Eeg Signalmentioning

confidence: 99%

Consequences of sleep deprivation

Orzeł-Gryglewska¹

2010

International Journal of Occupational Medicine and Environmental Health

211

133

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This paper presents the history of research and the results of recent studies on the effects of sleep deprivation in animals and humans. Humans can bear several days of continuous sleeplessness, experiencing deterioration in wellbeing and effectiveness; however, also a shorter reduction in the sleep time may lead to deteriorated functioning. Sleeplessness accounts for impaired perception, difficulties in keeping concentration, vision disturbances, slower reactions, as well as the appearance of microepisodes of sleep during wakefulness which lead to lower capabilities and efficiency of task performance and to increased number of errors. Sleep deprivation results in poor memorizing, schematic thinking, which yields wrong decisions, and emotional disturbances such as deteriorated interpersonal responses and increased aggressiveness. The symptoms are accompanied by brain tissue hypometabolism, particularly in the thalamus, prefrontal, frontal and occipital cortex and motor speech centres. Sleep deficiency intensifies muscle tonus and coexisting tremor, speech performance becomes monotonous and unclear, and sensitivity to pain is higher. Sleeplessness also relates to the changes in the immune response and the pattern of hormonal secretion, of the growth hormone in particular. The risk of obesity, diabetes and cardiovascular disease increases. The impairment of performance which is caused by 20-25 hours of sleeplessness is comparable to that after ethanol intoxication at the level of 0.10% blood alcohol concentration. The consequences of chronic sleep reduction or a shallow sleep repeated for several days tend to accumulate and resemble the effects of acute sleep deprivation lasting several dozen hours. At work, such effects hinder proper performance of many essential tasks and in extreme situations (machine operation or vehicle driving), sleep loss may be hazardous to the worker and his/her environment.

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“…A possible explanation is the fact that these studies utilize a wide variety of methods in small samples making it difficult to validate results. Several studies have been carried out through the application of psychomotor tests applied to a doctor after sleep deprivation and showed decreased reaction time, increased response time variability and increase drowsiness 10,13,14 Pilcher et al 15 published a meta-analysis that found that mood is more affected by sleep deprivation than either cognitive or motor performance and that partial sleep deprivation has a more profound effect on functioning than either longterm or short-term sleep deprivation. Ayas et al 16 showed a higher incidence of medical errors including wrong decision making and needlestick incidents.…”

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confidence: 99%

Effects of Acute Sleep Deprivation Resulting from Night Shift Work on Young Doctors

et al. 2015

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RESUMOIntrodução: Avaliar a privação do sono e seus efeitos sobre os jovens médicos relativamente à capacidade de concentração e desempenho psicomotor. Material e Métodos: Dezoito médicos, com idades entre 26 -33 anos, divididos em dois grupos: grupo sem privação de sono (sem trabalho nocturno) e grupo com privação de sono (no mínimo 12 horas de trabalho nocturno / semana). Aplicámos o Índice de Qualidade de Sono de Pittsburgh para rastrear a presença de patologia do sono e a Escala de Sonolência Epworth para avaliar subjectivamente a sonolência diurna; usamos actigrafia e o diário de sono para avaliar a higiene do sono e os ciclos de sono-vigília. Para demonstrar os efeitos da privação do sono, foi aplicado o teste de Toulouse-Piéron (teste de concentração) e uma bateria de três testes de tempo de reação após o período de trabalho nocturno. Resultados: O grupo com privação de sono apresentou maior sonolência diurna na Escala de Sonolência Epworth (p < 0,05) e durante a semana a privação de sono foi maior (p < 0,010). A duração média do sono durante o período de trabalho nocturno foi de 184,2 minutos para o grupo com privação de sono e 397,7 minutos para grupo sem privação de sono (p < 0,001). No teste Toulouse-Piéron o grupo com privação de sono apresentou maior número de omissões (p < 0,05) com um pior resultado no índice de concentração (p < 0,05). Os testes psicomotores que avaliaram a resposta a estímulos simples revelaram maior latência na resposta (p < 0,05) e mais erros (p < 0,05) no grupo com privação de sono; no teste de reacção a instrução o e grupo com privação de sono apresentou pior índice de perfeição (p < 0,05); no teste de movimentos finos não houve diferença estatisticamente significativa entre os grupos. Discussão: A privação de sono aguda resultante do trabalho nocturno em profissões médicas está associada a uma diminuição da atenção e concentração e no atraso de resposta a estímulos. Isto pode comprometer o atendimento ao paciente, bem como a saúde e a qualidade de vida do próprio médico. Conclusão: É essencial estudar os efeitos da privação aguda de sono sobre a capacidade cognitiva e de desempenho dos profissionais de saúde. Palavras-chave: Médicos; Privação de Sono; Tolerância ao Trabalho Programado; Ritmo Circadiano; Transtornos do Sono. ABSTRACT Introduction:To evaluate sleep deprivation and its effects on young physicians in relation to concentration capacity and psychomotor performance. Material and Methods:Eighteen physicians aged 26 -33 years were divided into 2 groups: non-sleep deprived group (with no night work) and sleep deprived group (minimum 12 hour of night work/week). We applied Pittsburgh Sleep Quality Index to screen the presence of sleep pathology and Epworth Sleepiness Scale to evaluate subjective daytime sleepiness; we used actigraphy and sleep diary to assess sleep hygiene and standard sleep-wake cycles. To demonstrate the effects of sleep deprivation, we applied ToulousePiéron's test (concentration test) and a battery of three reaction time tasks after the night duty...

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The effects of sleep deprivation on symptoms of psychopathology in healthy adults

Cited by 270 publications

References 43 publications

Sleep quality and paranoia: The role of alexithymia, negative emotions and perceptual anomalies

Sleep quality and paranoia: The role of alexithymia, negative emotions and perceptual anomalies

Consequences of sleep deprivation

Effects of Acute Sleep Deprivation Resulting from Night Shift Work on Young Doctors

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