The effects of single dose of methamphetamine on lipid peroxidation levels in the rat striatum and prefrontal cortex

Disparity in the temporal appearance of methamphetamine-induced apoptosis and depletion of dopamine terminal markers in the striatum of mice

“…One such mechanism may involve the generation of reactive oxygen species and the induction of lipid peroxidation and modification of proteins (protein carbonyls). Recent studies have detected soon after the systemic injection of METH, the induction of lipid peroxidation in the striatum, hippocampus, and prefrontal cortex [1,13]. METH induces lipid peroxidation in the striatum as early as 30 min after a single i.p.…”

Revisiting oxidative stress and mitochondrial dysfunction in the pathogenesis of Parkinson disease—resemblance to the effect of amphetamine drugs of abuse

“…In animal models, methamphetamine [312] and DͲamphetamine [313,314] also affected the activity of antioxidant enzymes. In addition, evidences of oxidative damage have been reported in the brains of metamphetamine human abusers [315] and methamphetamine [312] or DͲamphetamine [309]exposed animals.…”

Cellular and molecular mechanisms involved in the neurotoxicity of opioid and psychostimulant drugs

“…Moreover, in methamphetamine human abusers the activity of antioxidant enzymes was affected in several regions of the brain (Mirecki et al, 2004). In animal models, methamphetamine (Acikgoz et al, 2000) and D-amphetamine (Frey et al, 2006b;Carvalho et al, 2001) also affected the activity of antioxidant enzymes. In addition, evidences of oxidative damage have been reported in the brains of metamphetamine human abusers (Fitzmaurice et al, 2006) and methamphetamine (Acikgoz et al, 2000) or D-amphetamine (Frey et al, 2006a) exposed animals.…”

“…In animal models, methamphetamine (Acikgoz et al, 2000) and D-amphetamine (Frey et al, 2006b;Carvalho et al, 2001) also affected the activity of antioxidant enzymes. In addition, evidences of oxidative damage have been reported in the brains of metamphetamine human abusers (Fitzmaurice et al, 2006) and methamphetamine (Acikgoz et al, 2000) or D-amphetamine (Frey et al, 2006a) exposed animals. In catecholaminergic cell cultures, we have previously shown that chronic exposure to D-amphetamine induces a partial protection against H 2 O 2 -induced toxicity, which was suggested to be associated with adaptation to oxidative stress (Cunha- Oliveira et al, 2006c).…”