The effects of single application of pastes containing ion-releasing particles on enamel demineralization

Iijima, Masahiro; Kawaguchi, Kyotaro; Kawamura, Naohiko; Ito, Sachiko; Saito, Takashi; Mizoguchi, Itaru

doi:10.4012/dmj.2016-307

Cited by 16 publications

(9 citation statements)

References 28 publications

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“…The samples used in this study were 50 healthy human premolars, without caries, restorations, exposed dentin, erosion, abrasions, fissures, or micro-fractures. Before procedure, soft tissues or existing bone tissue remnants were removed from samples, washed with distilled water, and stored in 0.05% thymol solution to preserve permeability of DTs [6,15].…”

Section: Sample Preparation and Experimental Designmentioning

confidence: 99%

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Dentinal tubules obliteration using a toothpaste with nano-hydroxyapatite obtained from chicken eggshell

Huamán-Mujica¹,

Castañeda-Vía²,

García³

et al. 2022

jos

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Introduction: Dentin hypersensitivity is a common pathology, produced by exposed dental tubules. Objectives: The aim of this study was the evaluation of the effectiveness of experimental toothpaste based on nano-hydroxyapatite (nHAP) obtained from chicken eggshell in the obliteration of dentinal tubules (DTs). Material and methods: Toothpastes with different percentages of nHAP were formulated, including 3%, 7%, and 15% of nHAP, a commercial paste, and a toothpaste without nHAP. Assays were made using healthy premolar samples (n = 50). The pastes were applied and brushed for 7 days after a first erosive cycle, then a second erosive cycle was made at 15 days. Samples were analyzed using scanning electron microscopy and confocal Raman microscopy at three times: after the first erosive cycle (T0), after applications of the pastes (T7), and after the second erosive cycle (T15). Results:The quantitative analysis of the micrographs showed a significant difference between the experimental toothpastes with respect to the controls. Moreover, there was no statistically significant difference between the experimental toothpastes at time T7. By mineral concentration analysis, the 3%-nHAP toothpaste presented a significant difference against conventional toothpaste, when evaluating mineral concentration at 7 days. Conclusions: The experimental paste is effective in obliterating DTs at concentrations of 7 and 15%, in addition to being stable over time.

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Section: Sample Preparation and Experimental Designmentioning

confidence: 99%

“…Recently, nano-hydroxyapatite (nHAP) obtained from synthetic salts to be used against DH due to their potential effect of obliteration of DTs was introduced [5][6][7].…”

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confidence: 99%

Dentinal tubules obliteration using a toothpaste with nano-hydroxyapatite obtained from chicken eggshell

Huamán-Mujica¹,

Castañeda-Vía²,

García³

et al. 2022

jos

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“…S-PRG filler releases six types of ions: fluoride (F), sodium (Na), borate (B), aluminium (Al), silicate (Si), and strontium (Sr) ions [1] over a long period of time, thereby contributing to various bioactive functions that have led to the development of different types of dental materials based on this technology. Some of the reported effects of these ions include acid buffering ability [1,2], suppression of demineralization, enhancing enamel and dentin remineralization [3][4][5][6], and anti-plaque forming property [7][8][9]. Currently, S-PRG filler is incorporated in resin-based composites, fissure sealants, tooth surface coating materials, resin adhesives, and dental cements.…”

Section: Introductionmentioning

confidence: 99%

The effect of surface pre‐reacted glass‐ionomer filler eluate on dental pulp cells and mineral deposition on dentin: In vitro study

Nishimaki

Nassar

Tamura

et al. 2021

European J Oral Sciences

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The effects of surface pre-reacted glass-ionomer (S-PRG) filler on pulpal cells and on the composition of dentinal deposits were investigated. Proliferation (CCK-8), cytotoxicity (LDH), and differentiation activity (ALP) tests, along with cell morphology observations, were conducted at 6 and 24 h after treatment of pulpal cells with different S-PRG filler eluate concentrations. Dentinal surfaces were immersed in deionized water or S-PRG filler eluate followed by immersion in deionized water or simulated body fluid and observed under scanning electron microscope and elemental analysis using energy dispersive x-ray spectrometer. At 24 h, there were significant differences in CCK-8 and ALP activity values between the groups in a concentrationdependent manner. LDH test data were not significantly different among the groups.Cell morphology was not altered at either exposure time. However, decreased cellular density was observed with the highest eluate concentration. Crystalline deposits and occluded dentinal tubules were observed in samples immersed in S-PRG filler with a later immersion in simulated body fluid, which also showed higher concentrations of certain ions compared to surfaces that were not initially treated with S-PRG filler. The lowest two eluate concentrations did not show significant toxicity. S-PRG enhanced the effect of simulated body fluid in the formation of mineral deposits.

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“…Since fluoride application is well known for preventing dental caries, fluoride‐containing toothpastes, mouth rinses, bracket bonding adhesives and sealants are widely used in clinical orthodontics (Kohda et al, 2012; Paschos et al, 2009; Sudjalim et al, 2007; Ten Cate, 2013). A surface pre‐reacted glass‐ionomer (S‐PRG) filler is surrounded by stable glass‐ionomer layer by pre‐reacting acid‐reactive glass‐containing fluoride with polycarboxylic acid in the oral environment (Fujimoto et al, 2010; Iijima et al, 2014; Iijima et al, 2017; Ito et al, 2011; Shiiya et al, 2016). Such fillers have been widely adopted in dentistry, and can release multiple ions (Al 3+ , BO 3 3− , F − , Na + , SiO 3 2− , Sr 2+ ).…”

Section: Introductionmentioning

confidence: 99%

Effects of polishing with paste containing surface pre‐reacted glass‐ionomer fillers on enamel remineralization after orthodontic bracket debonding

Nagasaki

Ishikawa

Ito

et al. 2020

Microscopy Res & Technique

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Surface pre‐reacted glass‐ionomer (S‐PRG) technology allows for the release of multiple ions. This study was performed to investigate the remineralization of etched enamel after removal of the bracket using a novel paste containing S‐PRG filler. Surfaces of polished enamel were etched with phosphoric acid and then subdivided into two regions. Bracket bonding resin was thinly applied to one region. After 24‐hr immersion in artificial saliva, the bonding resin on the enamel surfaces was removed by grinding with tungsten carbide bur at low‐speed, followed by polishing with one of four different polishing systems: (a) nonfluoridated paste (NF); (b) fluoridated paste (F); (c) S‐PRG filler‐containing paste (S‐PRG); or (d) nonfluoridated plus S‐PRG filler‐containing paste (NF + S‐PRG) (n = 15). The polished specimens were then immersed in an artificial saliva solution for 7 days. Nanoindentation testing of enamel surfaces was performed and their mechanical properties were compared. Representative specimens were examined with scanning electron microscope. In all specimens, the mechanical properties of the enamel surfaces were markedly degraded by acid etching. However, the mechanical properties of both regions (etched and resin‐infiltrated enamels) showed recovery after polishing and 7‐day immersion. Polishing with NF + S‐PRG paste led to significant recovery of mechanical properties compared to polishing with NF or S‐PRG paste alone, and remineralization was equivalent to that seen with F paste. Porous etched enamel surfaces were filled with a remineralization layer after each polishing procedure and 7‐day immersion in all polishing groups. Polishing using NF + S‐PRG paste can facilitate enamel remineralization after bracket removal.

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The effects of single application of pastes containing ion-releasing particles on enamel demineralization

Cited by 16 publications

References 28 publications

Dentinal tubules obliteration using a toothpaste with nano-hydroxyapatite obtained from chicken eggshell

Dentinal tubules obliteration using a toothpaste with nano-hydroxyapatite obtained from chicken eggshell

The effect of surface pre‐reacted glass‐ionomer filler eluate on dental pulp cells and mineral deposition on dentin: In vitro study

Effects of polishing with paste containing surface pre‐reacted glass‐ionomer fillers on enamel remineralization after orthodontic bracket debonding

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