The effects of silver nanoparticles on oyster embryos

Ringwood, Amy H.; McCarthy, Melissa; Bates, Tonya C.; Carroll, David

doi:10.1016/j.marenvres.2009.10.011

Cited by 132 publications

(80 citation statements)

References 8 publications

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“…Oyster embryo was used to examine the toxic effects of silver nanoparticles on embryonic development. The study evidenced a significant increase in metallothionein gene expression in embryos [201]. Another study demonstrated the genotoxicity and cytotoxicity of silver nanoparticles on fish cells.…”

Section: Mechanistic Studiesmentioning

confidence: 83%

“…Silver nanoparticles are also known for genotoxicity and cytotoxicity in fish including accumulation in gill tissues and lysosomal destabilization in adult oysters. They are also known for adverse effects on oyster embryonic development, oxidative stress and expression of p53 protein in zebrafish [187,[199][200][201][202]. In another study conducted on zebrafish, it was observed that silver nanoparticles caused induction of apoptosis and oxidative stress in the liver.…”

Section: Mechanistic Studiesmentioning

confidence: 99%

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In vitro and in vivo toxicity assessment of nanoparticles

2017

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Nanotechnology has revolutionized gene therapy, diagnostics and environmental remediation. Their bulk production, uses and disposal have posed threat to the environment. With the appearance of these nanoparticles in the environment, their toxicity assessment is an immediate concern. This review is an attempt to summarize the major techniques used in cytotoxity determination. The review also presents a detailed and elaborative discussion on the toxicity imposed by different types of nanoparticles including carbon nanotubes, gold nanoparticles, silver nanoparticles, quantum dots, fullerenes, aluminium nanoparticles, zinc nanoparticles, iron nanoparticles, titanium nanoparticles and silica nanoparticles. It discusses the in vitro and in vivo toxological effects of nanoparticles on bacteria, microalgae, zebrafish, crustacean, fish, rat, mouse, pig, guinea pig, human cell lines and human. It also discusses toxological effects on organs such as liver, kidney, spleen, sperm, neural tissues, liver lysosomes, spleen macrophages, glioblastoma cells, hematoma cells and various mammalian cell lines. It provides information about the effects of nanoparticles on the gene-expression, growth and reproduction of the organisms.

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Section: Mechanistic Studiesmentioning

confidence: 83%

Section: Mechanistic Studiesmentioning

confidence: 99%

In vitro and in vivo toxicity assessment of nanoparticles

2017

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“…Early larval stages of bivalves have not been widely used until now to study the uptake and impact of nanoparticles (Ringwood et al, 2009, Kadar et al, 2010, Ringwood et al, 2010, Noventa et al, 2018a, Noventa et al, 2018b, despite their ability to bioconcentrate solid particles and the bioimaging advantage offered by their transparency and small size (approximately 70 µm). Early veliger larvae (alias D-shell shaped larvae, prodissoconch I) actively feed on suspended food particles, processing them through a well developed digestive apparatus (Yonge, 1926b, Millar, 1955, Galtsoff, 1964, Elston, 1980a, Waller, 1981, Bayne, 2017 (Figure 1).…”

mentioning

confidence: 99%

Gold nanoparticles ingested by oyster larvae are internalized by cells through an alimentary endocytic pathway

et al. 2018

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The biological fate of nanoparticles taken up by organisms from their environment is a crucial issue for assessing ecological hazard. Despite its importance, it has scarcely been addressed due to the technical difficulties of doing so in whole organism in vivo studies. Here, by using transmission electron microscopy and energy dispersive X-ray spectroscopy (TEM-EDS), we describe the key aspects that characterize the interaction between an aquatic organism of global ecological and 2 economic importance, the early larval stage of the Japanese oyster (Crassostrea gigas), and model gold nanoparticles dispersed in their environment. The small size of the model organism allowed for a high-throughput visualization of the subcellular distribution of nanoparticles, providing a comprehensive and robust picture of the route of uptake, mechanism of cellular permeation, and the pathways of clearance counterbalancing bioaccumulation. We show that nanoparticles are ingested by larvae and penetrate cells through alimentary pinocytic/phagocytic mechanisms. They undergo intracellular digestion and storage inside residual bodies, before excretion with feces or translocation to phagocytic coelomocytes of the visceral cavity for potential extrusion or further translocation. Our mechanistically-supported findings highlight the potential of oyster larvae and other organisms which feature intracellular digestion processes to be exposed to manmade nanoparticles and thus any risks associated with their inherent toxicity.

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“…While much of the research on AgNP has focused on freshwater systems and organisms, there have been several articles focused towards the effects of AgNP on marine invertebrates (Bianchini et al, 2007;Ringwood et al, 2010;Gomes et al, 2014). The sea urchin, as a globally distributed species, is widely used in embryology, developmental biology research and as a bioindicator.…”

mentioning

confidence: 99%

Effect of silver nanoparticles on Mediterranean sea urchin embryonal development is species specific and depends on moment of first exposure

Burić

Jakšić

Štajner

et al. 2015

Marine Environmental Research

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With the ever growing use of nanoparticles in a broad range of industrial and consumer applications there is increasing likelihood that such nanoparticles will enter the aquatic environment and be transported through freshwater systems, eventually reaching estuarine or marine waters. Due to silver's known antimicrobial properties and widespread use of silver nanoparticles (AgNP), their environmental fate and impact is therefore of particular concern.In this context we have investigated the species-specific effects of low concentrations of 60 The moment at which embryos first encounter AgNP is also shown to be an important factor in the development of abnormalities, and future applications of the sea urchin embryo development test for nanoparticle toxicity testing should carefully address the specific phase of development of embryos when nanoparticles are first introduced.

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The effects of silver nanoparticles on oyster embryos

Cited by 132 publications

References 8 publications

In vitro and in vivo toxicity assessment of nanoparticles

In vitro and in vivo toxicity assessment of nanoparticles

Gold nanoparticles ingested by oyster larvae are internalized by cells through an alimentary endocytic pathway

Effect of silver nanoparticles on Mediterranean sea urchin embryonal development is species specific and depends on moment of first exposure

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