1994
DOI: 10.1111/j.1476-5381.1994.tb13134.x
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The effects of sigma ligands and of neuropeptide Y on N‐methyl‐d‐aspartate‐induced neuronal activation of CA3 dorsal hippocampus neurones are differentially affected by pertussin toxin

Abstract: 1 The in vivo effects of the high affinity sigma ligands 1,3-di(2-tolyl)guanidine (DTG), ( + )-Ncyclopropylmethyl-N-methyl-1,4-diphenyl-l-ethyl-but-3-en-1-ylamine hydrochloride (JO-1784)

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Cited by 57 publications
(25 citation statements)
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References 43 publications
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“…The fact that JO-1784 is inactive by itself on [Ca 2ϩ ] i (after a pulse of Glu) may support the notion that 1 receptors exhibit differential sensitivity to 1 agonists (Monnet et al, 1994) and suggests that the molecular mechanism by which (ϩ)-benzomorphans and JO-1784 reduce the glutamate response differs from that responsible for the enhancement of the Glu. Hayashi et al (1995) using primary neuronal culture have shown a similar inhibitory effect of DTG on the NMDA receptor-induced [Ca 2ϩ ] i influx that we did.…”
Section: Discussionmentioning
confidence: 47%
“…The fact that JO-1784 is inactive by itself on [Ca 2ϩ ] i (after a pulse of Glu) may support the notion that 1 receptors exhibit differential sensitivity to 1 agonists (Monnet et al, 1994) and suggests that the molecular mechanism by which (ϩ)-benzomorphans and JO-1784 reduce the glutamate response differs from that responsible for the enhancement of the Glu. Hayashi et al (1995) using primary neuronal culture have shown a similar inhibitory effect of DTG on the NMDA receptor-induced [Ca 2ϩ ] i influx that we did.…”
Section: Discussionmentioning
confidence: 47%
“…Implication of pertussis toxin-sensitive heterotrimeric G i͞o proteins has been proposed previously in the immediate in vivo and in vitro modulation by 1 ligands of neuronal firing and potassium conductance (8)(9)(10). Here, we bring further support to this notion as we show that the intracellular steps of 1 receptor activation result in the recruitment of the subsequent, calcium-dependent PLC͞PKC cascade.…”
Section: Discussionmentioning
confidence: 93%
“…These characteristics, although alleviating the controversy on the 1 receptor molecular reality, do not fit with its currently proposed mechanisms of action on potassium conductances and coupling with heterotrimeric membrane-bound G proteins (8)(9)(10).…”
mentioning
confidence: 91%
“…Interestingly, in particular conditions, e.g. following Gi/o protein inactivation by pertussis toxin, haloperidol fails to reverse the effect of a agonists on the NMDA-induced neuronal activation (Monnet et al, 1994).…”
Section: Introductionmentioning
confidence: 99%