The Effects of Short-Term Chronic Ethanol Intoxication and Ethanol Withdrawal on the Molecular Composition of the Rat Hippocampus by FT-IR Spectroscopy

Abstract

Our results suggest that 15 days of binge-like drinking resulting in the high blood alcohol concentration (varying in the dose-dependent manner between 253 and 606 mg/dl) produced a strong physical dependence manifested mainly by the changes in lipid profiles pointing toward withdrawal-induced oxidative stress. These results show that ethanol withdrawal may cause equal to or even more severe brain damage than the ethanol itself, which should be considered when designing antialcohol therapies.

Structural effects of simvastatin on rat liver tissue: Fourier transform infrared and Raman microspectroscopic studies

“…The details of the method can be found in Severcan et al 44 This method was successfully applied to biological membranes and tissue proteins to predict the secondary structure of proteins. 32,38,45,46…”

Biophysical evaluation of physiological effects of gilthead sea bream (Sparus aurata) farming using FTIR spectroscopy

“…, respectively (Cakmak, Zorlu, Severcan, & Severcan, 2011;Chan, Bocian, & Petersen, 1981;Elibol-Can et al, 2011). In addition the intensity of the band at 3422 cm À1 decreased with respect to the band at 3300 cm À1 in the cultured fish liver cells considerably.…”

“…The CH 2 asymmetric stretching band shifting was also analysed and was found to decrease (2926.53 ± 0.74 (for wild fish liver cells) and 2925.96 ± 0.20 (for cultured fish liver cells)) indicating an increase in the cell membrane order as mentioned in Elibol-Can et al (2011).…”

Fourier Transform Infrared Spectroscopy as a Novel Approach for Analyzing the Biochemical Effects of Anionic Surfactants on a Surfactant-Degrading Arcobacter Butzleri Strain

“…The gradual and considerable increase in the area-percentage values of turns (Table I) in a surfactant concentration-dependent manner supports the idea that SDS is responsible for denaturation of proteins in bacteria. 26 In particular, the comparative increase in turns for the 100 and especially the 3000 mg/L samples on day 3 is attributable to denatured proteins. Therefore, differential protein expression and denaturation could have contributed to the marked differences observed between protein secondary structures of 100 and 3000 mg/L samples on day 3.…”