The Effects of Sevoflurane, Halothane, Enflurane, and Isoflurane on Hepatic Blood Flow and Oxygenation in Chronically Instrumented Greyhound Dogs

Influence of desflurane, isoflurane and halothane on regional tissue perfusion in dogs

“…The effects of isoflurane on renal and hepatic blood flow demonstrated in the current investigation are also partially supported by several previous studies ,32-37 although presence of baseline anaesthetics, acute surgical preparation and use of different animal species complicate direct comparison between these studies and the current investigation. Similar discrepancies also make comparison with previous studies examining the effect of halothane on hepatic blood flow difficult, although the present findings clearly support those of Gelman et al 36 and Frink et al 37 who demonstrated decreases in hepatic arterial blood flow with halothane but not isoflurane in pentobarbital anaesthetized, acutely instrumented dogs (by the radioactive microsphere technique) and chronically instrumented dogs (using electromagnetic flow probes), respectively. This investigation represents the first to examine specifically the effects of the desflurane on splanchnic and skeletal muscle blood flow.…”

Imaging and tissue biodistribution of 99mTc-labeled adenovirus knob (serotype 5)

“…The difference between 16.1 s (theoretical maximum) and 22.7 s (dynamic measured value) is probably related to decreased cardiac output by the halothane anesthesia. 25 Therefore, these results would indicate that the 99m TcAd5K had a 100% extraction efficiency by the liver until receptor saturation and that initial binding was limited only by blood flow to the liver.…”

Noninvasive ICG clearance test for estimating hepatic blood flow during halothane and isoflurane anaesthesia

“…Bernard et al 2~ observed no change in HBF during isoflurane anaesthesia in the chronically instrumented dogs. Frink et al 17 observed a decrease in PBF and total hepatic blood flow in greyhounds, though the effect of isoflurane was less than that of halothane. These conflicting results may be due to the differences of breeds (mongrel dog vs greyhound) or techniques for estimating HBF (electromagnetic flow probe vs pulsed Doppler flow probe vs labeled microspheres).…”

“…Halothane impairs this response and decreases HBF secondary to reductions in both portal blood flow and hepatic arterial blood flow in animal studies. i-3, [17][18][19] In dogs, Gelman et al 3 reported that the hepatic arterial buffer response was maintained during isoflurane anaesthesia; the decrease in PBF was compensated by the increase of hepatic arterial blood flow. Although ICG clearance did not correlate with changes in liver blood flow in their experiment, they observed that ICG clearance decreased during halothane anaesthesia and did not change during isoflurane anaesthesia.…”