The Effects of Serum Calcium and Parathyroid Hormone Changes on Psychological and Cognitive Function in Patients Undergoing Parathyroidectomy for Primary Hyperparathyroidism

Abstract

Reduction in mood and anxiety symptoms is associated with reductions in both iPTH and spatial working memory in patients with pHPT who undergo successful parathyroidectomy.

Surgery for ‘asymptomatic’ mild primary hyperparathyroidism improves some clinical symptoms postoperatively

“…Roman et al (17) showed that reduction in mood swings and anxiety symptoms were associated with reduction of PTH level in patients with pHPT who underwent successful parathyroidectomy. Weber et al (18) confirmed that depression, anxiety, and impaired quality of life were related to pHPT.…”

Minimally Invasive Parathyroidectomy for Primary Hyperparathyroidism - Current Views, Issues and Controversies

“…One of the explanations for this is that it is believed that there is a strong link between serum calcium levels and cognitive function. (Roman et al, 2011) In a general population cohort study of more than 4000 individuals, Schram et al found that high serum calcium levels were associated with faster decline in cognitive function, especially for people older than 75 years. This finding persisted even if people with abnormally high serum calcium levels were excluded.…”

“…Examination of change scores revealed that postoperative reduction in PTH was associated with a decrease in state anxiety, which was also associated with improvement in visuospatial working memory. (Roman et al, 2011) …”

Asymptomatic Primary Hyperparathyroidism

“…Several studies have specifically addressed cognitive function in PHPT (31)(32)(33)(34)(35)(36). Data interpretation has been limited by small sample sizes, issues with control populations, generalizations from narrow testing of cognitive domains, and variable follow-up periods.…”