The effects of serotonin on the electrophysiological properties of atrioventricular node during an experimental atrial fibrillation

Changizi, Shima; Khori, Vahid; Alizadeh, Ali Mohammad

doi:10.1007/s00210-015-1123-4

Cited by 5 publications

(3 citation statements)

References 20 publications

(27 reference statements)

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“…Therefore, drugs targeting on the serotonin system, such as serotonin receptor agonist and antagonists, are used in the treatment of motility disorders. Although these drugs can relieve the patients' symptoms, there are also some dangerous adverse effects, such as arrhythmia [ 16 , 17 ]. Thus, it is crucial to find a new therapeutic approach to relieve gastrointestinal dysmotility associated with obesity.…”

Section: Introductionmentioning

confidence: 99%

Fecal Microbiota Transplantation Can Alleviate Gastrointestinal Transit in Rats with High-Fat Diet-Induced Obesity via Regulation of Serotonin Biosynthesis

Sun

Guo

Zhang

et al. 2018

BioMed Research International

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Aim We tested the hypothesis that fecal microbiota transplantation (FMT) could regulate the biotransformation of bile acids, such as deoxycholic acid (DCA) and cholic acid (CA), which in turn regulate the biosynthesis of serotonin in the gut and relieve gastrointestinal dysmotility in high-fat diet- (HFD-) induced obesity in rats. Methods Male Sprague-Dawley rats were randomly divided into the control diet group, HFD group, and HFD-fed with receiving FMT. HFD was fed for 12 weeks. At the end of two-week HFD, FMT was carried out for two weeks. The gastrointestinal transit, serotonin concentration, the expression of tryptophan hydroxylase 1 (TPH1) and serotonin reuptake transporter (SERT), and the levels of bile acids in intestinal contents were examined. Results Compared with the control group, the gastrointestinal transit and small intestinal serotonin concentration of HFD-fed rats were increased. In HFD-fed rats, TPH1 protein expression was increased significantly, while SERT protein expression was decreased, but not significant. The levels of CA and DCA in intestinal contents were also significantly increased in HFD-fed rats compared with the control group. After HFD-fed rats receiving FMT treatment, the gastrointestinal transit, small intestinal serotonin concentration, and TPH1 expression were decreased, while SERT expression was not affected. Moreover, the levels of CA and DCA in intestinal contents were also decreased. Conclusions FMT could alleviate small intestinal transit in the HFD-fed rats by regulating the serotonin biosynthesis. In this process, CA and DCA may be related to the regulation of synthesis of serotonin.

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Section: Introductionmentioning

confidence: 99%

Fecal Microbiota Transplantation Can Alleviate Gastrointestinal Transit in Rats with High-Fat Diet-Induced Obesity via Regulation of Serotonin Biosynthesis

Sun

Guo

Zhang

et al. 2018

BioMed Research International

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“…Interestingly our patient had no structural heart disease but has a past history of migraine and takes rizatriptan, a serotonin (5-HT) receptor agonist. 5-HT has been shown to cause prolongation of the nodal refractoriness more than atrial-His conduction time which leads to an increase in the excitability index without significant reduction of the ventricular rates during AF [ 10 ]. The presence of comorbidities like coronary atherosclerosis, obesity, dyslipidemia, hypertension, and hypothyroidism in our patient may have led to a predisposition for increased sympathetic tone, autonomic dysregulation, and increased sensitivity of the cardiac tissue to adenosine leading to paroxysmal atrial fibrillation that was unmasked by IV adenosine administration during cardiac catheterization [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

Adenosine-Induced Atrial Fibrillation During Coronary Angiography and Fractional Flow Reserve Procedures

Bhatheja¹,

Bajwa²,

Kapoor³

2023

Cureus

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A woman in her sixties presented with a history of progressive shortness of breath, palpitations, and feeling of chest heaviness for the last eight months. To rule out underlying obstructive coronary artery disease, an invasive cardiac catheterization was planned. To assess the hemodynamic significance of the lesion, resting full cycle ratio (RFR) and fractional flow reserve (FFR) values were measured. During this procedure, almost immediately after starting IV adenosine infusion, the patient went into atrial fibrillation which was reversed by IV aminophylline. Awareness of this uncommon effect of adenosine on the cardiac electrical pathways merits knowledge and a thorough follow-up testing of these patients is justified.

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“…Increased cytosolic IP 3 causes sarcoplasmic reticulum (SR) Ca 2+ release via IP 3 ‐receptor ligand‐gated Ca 2+ channels, leading to tachycardia and arrhythmia in various vertebrate models (Bramich et al., ; Centurión et al., ; Villalón and Centurión, ; Zima and Blatter, ). Serotonin was also shown to induce β‐adrenergic receptor activity in the rabbit atrioventricular node (Changizi et al., ).…”

Section: Discussionmentioning

confidence: 99%

Suppression of Tryptophan 2,3-Dioxygenase Produces a Slow Heartbeat Phenotype inDrosophila melanogaster

Beasley

Dowse

2016

J. Exp. Zool.

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The primary pathway utilizing tryptophan leads initially to kynurenine before branching. Products include nicotinamide adenine dinucleotide and important pigments in the eye. Products in this pathway have been linked to a number of pathologies. The gene encoding the first step in this pathway, tryptophan 2,3-dioxegenase, is encoded by the gene vermilion, initially discovered in Drosophila. In the fly, v is an important eye color marker, but is found to have multiple pleiotropic effects. We have uncovered significant effects of this mutation on the fly heart. The heart beats more slowly and more rhythmically in both males and females and in strains which we have outcrossed. In addition, the fly heart normally beats irregularly with multiple brief stoppages, and the time structure of these stoppages, as investigated by looking at interbeat intervals, is changed in flies bearing this mutation. Fewer flies bearing the v mutation show long hiatuses in beat compared to wild type, however, in some strains of the mutant animals that do, the number of stoppages in much greater and the mean duration is longer.

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The effects of serotonin on the electrophysiological properties of atrioventricular node during an experimental atrial fibrillation

Cited by 5 publications

References 20 publications

Fecal Microbiota Transplantation Can Alleviate Gastrointestinal Transit in Rats with High-Fat Diet-Induced Obesity via Regulation of Serotonin Biosynthesis

Fecal Microbiota Transplantation Can Alleviate Gastrointestinal Transit in Rats with High-Fat Diet-Induced Obesity via Regulation of Serotonin Biosynthesis

Adenosine-Induced Atrial Fibrillation During Coronary Angiography and Fractional Flow Reserve Procedures

Suppression of Tryptophan 2,3-Dioxygenase Produces a Slow Heartbeat Phenotype inDrosophila melanogaster

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