The Effects of Selenium in Acrylamide-Induced Nephrotoxicity in Rats: Roles of Oxidative Stress, Inflammation, Apoptosis, and DNA Damage

Şengül, Emin; Gelen, Volkan; Yıldırım, Serkan; Tekin, Samet; Dağ, Yusuf

doi:10.1007/s12011-020-02111-0

Cited by 50 publications

(60 citation statements)

References 63 publications

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“…Apoptosis is also another pathogenic mechanism through which ACR induced renal affection [23]. BAX reaction increased 4.5-fold in the ACR group.…”

Section: Discussionmentioning

confidence: 99%

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Protective effect of resveratrol on acrylamide-induced renal impairment

Nasralla¹,

Zaki

Attia

2021

Folia Morphol

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“…Apoptosis is also another pathogenic mechanism through which ACR induced renal affection [23]. BAX reaction increased 4.5-fold in the ACR group.…”

Section: Discussionmentioning

confidence: 99%

“…Oxidative stress is a shift in the balance between oxidants and antioxidants in favor of oxidants [3]. Many researchers proved the oxidative stress role of ACR over the kidney [23]. The values of the oxidative marker (MDA) in the ACR group increased by 1.4-fold, while the anti-oxidative marker (GSH) decreased by 1.3-fold.…”

Section: Discussionmentioning

confidence: 99%

Protective effect of resveratrol on acrylamide-induced renal impairment

Nasralla¹,

Zaki

Attia

2021

Folia Morphol

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“…The data obtained from our study were similar to the ndings study and the expression of 8-OHdG increased in renal tissues of mice in the 5-FU group. On the other hand, some studies have shown that the application of various antioxidant agents inhibits oxidative stress-induced DNA damage (Ince et al 2014;Sengul et al 2021).This shows that SLY has an antioxidant effects and thus reduce ROS-mediated 8-OHdG expression, thus preventing oxidative DNA damage.…”

Section: Immunohistochemical Ndingsmentioning

confidence: 98%

“…Serum urea and creatinine levels are biomarkers of kidney function, and serum levels increase when kidney tissue is damaged. (Chahdoura et al 2018;Dağ et al 2018;Sengul et al 2021). According to the data we obtained in our study, liver urea, creatinine, ALT, AST, and total bilirubin increased signi cantly in the 5-FU group compared to the control group.…”

Section: Immunohistochemical Ndingsmentioning

confidence: 99%

Investigation of Effects of Silymarin in 5-Fluorouracil Hepatotoxicity and Nephrotoxicity in Mice

Şengül

Gelen

Yıldırım

et al. 2021

Preprint

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Hepatotoxicity and nephrotoxicity are common side effects of 5-Fluorouracil (5-FU). The present study aimed to investigate the effects of Silymarin (SLY) on 5-FU induced hepatotoxicity and nephrotoxicity in mice. In our study, 10 mice in each group were randomly divided into four groups as the control group, 5-FU, SLY50+5-FU, and SLY100+5-FU group. SLY50+5-FU and SLY100+5-FU groups were administered at a dose of 50 and 100 mg/kg for seven days, respectively. 5-FU was administered at a dose of 400 mg/kg intraperitoneally on the fourth day. After the applications, the mice were decapitated under anesthesia. The liver and kidney functions which urea, creatinine, AST, ALT, and total bilirubin levels were analyzed in serum. In liver and renal tissues, MDA and GSH levels, SOD, CAT, and GR activity were determined. Also, histopathological and immunohistochemical changes were examined in liver and kidney sections. Urea, creatinine, ALT, AST, and total bilirubin levels increased 5-FU group according to control and prevented to this increases the especially high dose of SLY. 5-FU also causes histopathological and immunohistochemical changes such as degeneration, necrosis, hyperemia, DNA damage, and IL-6 increase in kidney and liver tissue. High doses of SLY prevented these changes caused by 5-FU. As a result of this study, it was determined that SLY has hepatoprotective and nephroprotective effects on 5-FU-induced liver and kidney damage in mice.

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“…It has been determined as a result of studies that CCl4 causes organ toxicities in tissues such as liver [6], heart [7], brain [8] and kidney [9]. In various recent studies, some flavonoids and natural ingredients are used to prevent the harmful effects of some toxic substances on the organs [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29]. One of these substances is resveratrol.…”

Section: Introductionmentioning

confidence: 99%

Protective effects of resveratrol on kidney function tests and renal histopathology in carbon tetrachloride-induced renal toxicity in rats

Gelen¹,

Şengül²

2021

World J. Adv. Res. Rev.

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In this study, it was aimed to investigate the protective effect of Resveratrol, which has a strong antioxidant effect on kidney tissues of rats experimentally induced with carbon tetrachloride with nephrotoxicity, by kidney function tests and histopathology. For this purpose, 32 male Wistar Albino rats were used. The subjects were randomly selected, 1st group control, 2nd group CCl4, 3rd group Resveratrol. The 4th group was divided into 4 groups as CCl4 + Resveratrol. At the end of the experiment, animals were sacrificed under anesthesia and kidney samples were taken in 10% formalin solution for histopathological analysis. In the histopathological examination, it was found that the rats in the control and Resveratrol groups had normal kidney histological structure. In CCI4 group, severe hydropic degeneration in tubules epithelium, mild coagulation necrosis in tubules epithelium and severe hyperemia in the vessels were observed. When kidney tissues of rats were examined in CCI4 + Resveratrol group, mild hydropic degeneration in tubules epithelium and mild hyperemia in vessels were observed. When the kidney tissues of the rats in the Resveratrol group were examined, it was observed that they had a normal histological appearance. As a result, it was determined that Resveratrol has a protective effect on kidney damage caused by CCI4.

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The Effects of Selenium in Acrylamide-Induced Nephrotoxicity in Rats: Roles of Oxidative Stress, Inflammation, Apoptosis, and DNA Damage

Cited by 50 publications

References 63 publications

Protective effect of resveratrol on acrylamide-induced renal impairment

Protective effect of resveratrol on acrylamide-induced renal impairment

Investigation of Effects of Silymarin in 5-Fluorouracil Hepatotoxicity and Nephrotoxicity in Mice

Protective effects of resveratrol on kidney function tests and renal histopathology in carbon tetrachloride-induced renal toxicity in rats

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