The Effects of Scolicidal Agent Propolis on Liver and Biliary Tree

Kısmet, Kemal; Kılıçoğlu, Sibel Serin; Kilicoglu, Bulent; Erel, Serap; Gençay, Ömür; Sorkun, Kadriye; Erdemlı, Esra; Akhan, Okan; Akkuş, Mehmet Ali; Sayek, İskender

doi:10.1007/s11605-008-0555-2

Cited by 8 publications

(5 citation statements)

References 13 publications

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“…The fatality rate of glucose at different concentrations on protoscolices was further examined by increasing the exposure times which demonstrated the effect of time on eliminating the viability of protoscolices. Moreover, our results showed that, at a fixed exposure time, increasing the glucose concentrations led to reduced viability of protoscolices, a finding in agreement with the results of other researchers [ 5 , 14 – 16 ]. Of course, glucose in some gradually increasing concentrations including 10%, 15%, 20%, 25%, and 30% and exposure times such as 1, 2, 3, 4, 5, 6, 7, 8, 9, and 10 min produced a little effect on protoscolices with no significant difference.…”

Section: Discussionsupporting

confidence: 93%

Study of Protoscolicidal Effects of Hypertonic Glucose on Protoscolices of Hydatid Cyst at Different Concentrations and Exposure Times

Shahnazi

Badakhsh

Azadmehr

et al. 2014

International Scholarly Research Notices

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Surgical operation is the treatment of choice for hydatid cyst. To date, many protoscolicidal substances have been used for inactivation of hydatid cyst contents but most of these compounds may produce several side effects. The aim of this study was to evaluate the protoscolicidal effects of hypertonic glucose on protoscolices of hydatid cyst at different concentrations and exposure times. Protoscolices were obtained aseptically from the livers of slaughtered sheep at Qazvin abattoir, Iran. Protoscolices were exposed to different concentrations of hypertonic glucose (10%, 15%, 20%, 25%, 30%, 40%, and 50%) at different times (1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 20, 30, 40, 50, and 60 min). Viability of protoscolices was evaluated by 0.1% eosin and the movement of protoscolices flame cells. The highest protoscolicidal effect (100%) of hypertonic glucose was obtained at concentrations 40% and 50% following 40 and 20 min exposure times, respectively. Some protoscolicidal agents show a variety of dangerous complications such as biliary tract fibrosis and liver necrosis; however, hypertonic glucose especially at a concentration of 40% may demonstrate less side effects compared with glucose 50%. Further in vivo investigations are suggested.

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Section: Discussionsupporting

confidence: 93%

Study of Protoscolicidal Effects of Hypertonic Glucose on Protoscolices of Hydatid Cyst at Different Concentrations and Exposure Times

Shahnazi

Badakhsh

Azadmehr

et al. 2014

International Scholarly Research Notices

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“…[29][30][31][32][33] , Trichomonas vaginalis 32 . In vitro effects of this product on protoscoleces have been reported in two study 34,35 . We determined that 0.50 mg/mL concentration of propolis killed all of the protoscoleces at the end of the 3rd minute.…”

Section: Cmjmentioning

confidence: 88%

The scolocidal effect of propolis on protoscoleces and daugther cysts

Özçelık¹,

Sümer²,

Değerlı³

2015

Cumhuriyet Med J

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SUMMARYObjective: Scolocidal elements are used in the aim of not scattering the protoscoleces' outside the cyst during the treatment of cyst hydatid in our present-day. It is hoped from the scolocidal materials; besides its effect on protoscoleces, not being toxic, being easy practicable, not causing sclerozan cholanjit and if possible, penetrating in the daughter vesicules. In this research, the effect of propolis which is a bee product on protoscoleces were investigated. Methods: In our work, daughter vesicules and protoscoleces obtain from the liver of a patient during surgery and propolis from the Black Sea Region were used. Viability tests were done by using 0.1% eosine solution. After propolis disolved in dimethylsulfoxide, within the range of 50 mg/mL and 0.010 mg/mL using by 0.9% serum physiological solution 100 µl into each of the tube and in 1.,3.,5.,10.,20.,and 30. minutes the rates of viability of protoscolex (4000 protoscolex/mL) are fixed. The research were subjected to daughter vesicules that is 4-7 mm in diameters. The concentration of propolis at 0.80 and 3.12 mg/mL were investigated viability rates of protoscolex at different incubation time and whether the possibilty of penetration to the daughter vesicules. Results: It was seen that protoscolexs were effected by the Propolis at 0.100 mg/mL concentration in the first minute, at 0.050 mg/mL concentration in the 3. minutes, at 0.025 mg/mL concentration at 10. minutes and at 0.010 mg/mL concentration in 20. minutes. For protoscolex in the vesicules at 0.80 mg/mL concentration in 20. minute, in 3.12 mg/mL concentration in 10. minutes were found to be lethal. Conclusions: As the protoscolex could be killed by Propolis which penetrate to daughter cysts in a very short time as 10 minutes, we thing that it will be beneficial completing advanced studies.

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“…These can only be removed by surgery or percutaneous aspiration, which does not nullify the risk of disruption of the hydatid cyst, release of protoscoleces into adjacent tissues and dissemination of the infection [99] . An ethanolic Turkish propolis extract showed intense scolicidal activity in vitro ( Table 3, Figure 4), whereas there were no pathological effects in the liver and biliary tree of Wistar rats [100] …”

Section: Helminthsmentioning

confidence: 99%

Antiparasitic Properties of Propolis Extracts and Their Compounds

Paula

Cândido

Santos

et al. 2021

Chemistry & Biodiversity

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Propolis is a bee product that has been used in medicine since ancient times. Although its anti‐inflammatory, antioxidant, antimicrobial, antitumor, and immunomodulatory activities have been investigated, its anti‐parasitic properties remain poorly explored, especially regarding helminths. This review surveys the results obtained with propolis around the world against human parasites. Regarding protozoa, studies carried out with the protozoa Trypanosoma spp. and Leishmania spp. have demonstrated promising results in vitro and in vivo. However, there are fewer studies for Plasmodium spp., the etiological agent of malaria and less so for helminths, particularly for Fasciola spp. and Schistosoma spp. Despite the favorable in vitro results with propolis, helminth assays need to be further investigated. However, propolis has shown itself to be an excellent natural product for parasitology, thus opening new paths and approaches in its activity against protozoa and helminths.

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The Effects of Scolicidal Agent Propolis on Liver and Biliary Tree

Abstract: Propolis may be used as a scolicidal agent even in the case of cystobiliary communication with no side effects on liver and biliary tree.

Cited by 8 publications

References 13 publications

Study of Protoscolicidal Effects of Hypertonic Glucose on Protoscolices of Hydatid Cyst at Different Concentrations and Exposure Times

Study of Protoscolicidal Effects of Hypertonic Glucose on Protoscolices of Hydatid Cyst at Different Concentrations and Exposure Times

The scolocidal effect of propolis on protoscoleces and daugther cysts

Antiparasitic Properties of Propolis Extracts and Their Compounds

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