The effects of rice bran oil on left ventricular systolic function, cardiometabolic risk factors and inflammatory mediators in men with coronary artery disease: a randomized clinical trial

Mahdavi-Roshan, Marjan; Salari, Arsalan; Ghorbani, Zeinab; Nikpey, Zahra; Haghighatkhah, Motahare; Mousavi, Aboozar Fakhr; Gholipour, Mahboobeh; Pourfarzad, Amir

doi:10.1039/d1fo00094b

Cited by 3 publications

(13 citation statements)

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“…The studied subjects’ recruitment procedure has been described elsewhere [ 26 ]. Briefly, from the 40 enrolled patients, 37 individuals completed the study.…”

Section: Resultsmentioning

confidence: 99%

“…The research design and data gathering details have been described elsewhere [ 26 ]. Concisely, forty male patients with the diagnosis of severe CAD following percutaneous coronary angioplasty in Heshmat Cardiovascular hospital, Guilan University of Medical Sciences (GUMS), were included in the present RCT from 2019 (April) to 2020 (September).…”

Section: Methodsmentioning

confidence: 99%

“…The RBO used in the present study was a product of Giltaz Company located in Rasht, Guilan province in Iran. The details on the fatty acid composition of the applied oils have been illustrated earlier [ 26 ].…”

Section: Methodsmentioning

confidence: 99%

“…At the first visit and post-intervention, fasting venous blood samples were collected from all enrolled individuals to assess lipid profile, fasting blood sugar (FBS), and serum inflammatory mediators (tumor necrosis factor-alpha (TNF-α) in addition to high-sensitive C-reactive protein (hs-CRP)). More details on laboratory analysis have been reported in the previous publication [ 26 ].…”

Section: Methodsmentioning

confidence: 99%

“…In the light of these pieces of evidence, recently, the current research team has conducted a randomized controlled trial (RCT) aiming to explore the metabolic capabilities of RBO compared to the conventional oil, sunflower oil (SFO), plus a standard diet, among the men suffering from CAD. It was delineated that RBO consumption resulted in improving left ventricular dysfunction and serum levels of metabolic and inflammatory markers and single lipid parameters, except for HDL-C [ 26 ]. Considering that the atherogenicity and insulin resistance indices mentioned above could further the present knowledge regarding atherosclerosis progression and yield a deeper understanding of lipoproteins balance, insulin resistance, and response to treatment among CAD patients, in the present research, therefore, it is attempted to extend the previous analysis.…”

Section: Introductionmentioning

confidence: 99%

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Rice bran oil could favorably ameliorate atherogenicity and insulin resistance indices among men with coronary artery disease: post hoc analysis of a randomized controlled trial

et al. 2021

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Background Despite recent advances in recognizing more reliable indicators to estimate the coronary artery disease (CAD) patients’ response to treatment and prognosis, less attention has been paid to evaluating them in clinical trials. Hence, the present research was conducted to study the impact of rice bran oil (RBO) versus sunflower oil (SFO) on various atherogenicity and insulin resistance markers. Methods In the present 8-week randomized controlled trial, 40 CAD men with an average age of 56 years were allocated randomly into the intervention or control group to use RBO or SFO (30 g/day) plus a standardized dietary plan. As a further analysis, eight atherosclerosis-related indices were calculated before and after the study. Results Analysis of covariance test in which potential confounders and baseline levels were considered, indicated that using RBO compared to SFO reduced Castelli’s risk index I and II (adjusted means:3.29, 1.52 vs. 4.61, 2.20, respectively), atherogenic coefficient (2.29 vs. 3.61), lipoprotein combine index (6.54 vs. 17.53), and cholesterol index (0.46 vs. 1.20) after the trial (P-value ≤ 0.002). Also, the RBO group yielded significantly lower triglyceride glucose index (8.73 vs. 9.13) (P-value = 0.010). Further, marginally significant amelioration in triglyceride/HDL ratio and atherogenic index of plasma (1.48 and 0.13 vs. 1.86 and 0.24 respectively) were noted (P-value = 0.07). Spearman correlation analysis detected significant positive correlations between alterations in TNF-α serum levels (ng/L) and the majority of evaluated indices (P-value < 0.05). Conclusion Taken together, incorporating 30 g of RBO into the patient’s usual diet appeared effective in ameliorating atherogenicity and insulin resistance indicators among men with CAD, probably in relation to its anti-inflammatory properties. Trial registration The protocol of the current trial was retrospectively recorded in the Iranian clinical trial registration system (IRCT) with the registration number of IRCT20190313043045N1 (URL: https://en.irct.ir/trial/38346; Registration date: 2019-04-27).

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“…The studied subjects’ recruitment procedure has been described elsewhere [ 26 ]. Briefly, from the 40 enrolled patients, 37 individuals completed the study.…”

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Rice bran oil could favorably ameliorate atherogenicity and insulin resistance indices among men with coronary artery disease: post hoc analysis of a randomized controlled trial

et al. 2021

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An open label randomized controlled trial of the effects of rice bran oil on cardiometabolic risk factors, lipid peroxidation and antioxidant status in overweight/obese adults with metabolic syndrome

Mahdavi-Roshan,

Shoaibinobarian,

Evazalipour

et al. 2024

Lipids Health Dis

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Gout and Diet: A Comprehensive Review of Mechanisms and Management

et al. 2022

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Gout is well known as an inflammatory rheumatic disease presenting with arthritis and abnormal metabolism of uric acid. The recognition of diet-induced systemic metabolic pathways have provided new mechanistic insights and potential interventions on gout progression. However, the dietary recommendations for gouty patients generally focus on food categories, with few simultaneous considerations of nutritional factors and systemic metabolism. It is worthwhile to comprehensively review the mechanistic findings and potential interventions of diet-related nutrients against the development of gout, including purine metabolism, urate deposition, and gouty inflammation. Although piecemeal modifications of various nutrients often provide incomplete dietary recommendations, understanding the role of nutritional factors in gouty development can help patients choose their healthy diet based on personal preference and disease course. The combination of dietary management and medication may potentially achieve enhanced treatment effects, especially for severe patients. Therefore, the role of dietary and nutritional factors in the development of gout is systematically reviewed to propose dietary modification strategies for gout management by: (1) reducing nutritional risk factors against metabolic syndrome; (2) supplementing with beneficial nutrients to affect uric acid metabolism and gouty inflammation; and (3) considering nutritional modification combined with medication supplementation to decrease the frequency of gout flares.

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The effects of rice bran oil on left ventricular systolic function, cardiometabolic risk factors and inflammatory mediators in men with coronary artery disease: a randomized clinical trial

Abstract: Background/Objective In the current study, we aimed to explore the effects of rice bran oil (RBO) in adjunct to conventional medical therapy on left ventricular ejection fraction (LVEF), cardiometabolic risk...

Cited by 3 publications

References 30 publications

Rice bran oil could favorably ameliorate atherogenicity and insulin resistance indices among men with coronary artery disease: post hoc analysis of a randomized controlled trial

Rice bran oil could favorably ameliorate atherogenicity and insulin resistance indices among men with coronary artery disease: post hoc analysis of a randomized controlled trial

An open label randomized controlled trial of the effects of rice bran oil on cardiometabolic risk factors, lipid peroxidation and antioxidant status in overweight/obese adults with metabolic syndrome

Gout and Diet: A Comprehensive Review of Mechanisms and Management

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