The effects of reversible inactivation of postero-temporal visual cortex on neuronal activities in cat's area 17

Huang, Jin Yu; Wang, Chun; Dreher, Bogdan

doi:10.1016/j.brainres.2006.12.081

Cited by 30 publications

(37 citation statements)

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“…Potential residual eye movements were prevented by bilateral cervical sympathec- 18, 19, 20a, 20b, 21a, and 21b, as well as topographically organized areas [anterolateral (ALLS), anteromedial (AMLS), dorsal (DLS), posterolateral (PLLS), posteromedial (PMLS), and ventral lateral suprasylvian (VLS) areas], anterior ectosylvian area (AEV), and posterior suprasylvian area (PS) in the left cerebral hemisphere, are indicated (cf. Huang et al 2007). MS, marginal sulcus; SSS, superior suprasylvian sulcus.…”

Section: Methodsmentioning

confidence: 99%

Phase sensitivities, excitatory summation fields, and silent suppressive receptive fields of single neurons in the parastriate cortex of the cat

Romo

Wang

Zeater

et al. 2011

Journal of Neurophysiology

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Romo PA, Wang C, Zeater N, Solomon SG, Dreher B. Phase sensitivities, excitatory summation fields, and silent suppressive receptive fields of single neurons in the parastriate cortex of the cat. J Neurophysiol 106: 1688 -1712, 2011. First published June 29, 2011 doi:10.1152/jn.00894.2010We have recorded single-neuron activity from cytoarchitectonic area 18 of anesthetized (0.4 -0.7% isoflurane in 65% N 2 O-35% O 2 gaseous mixture) domestic cats. Neurons were identified as simple or complex on the basis of the ratios between the phase-variant (F1) component and the mean firing rate (F0) of spike responses to optimized (orientation, direction, spatial and temporal frequencies, size) high-contrast, luminance-modulated, sinewave drifting gratings (simple: F1/F0 spike-response ratios Ͼ 1; complex: F1/F0 spike-response ratios Ͻ 1). The predominance (ϳ80%) of simple cells among the neurons recorded from the principal thalamorecipient layers supports the idea that most simple cells in area 18 might constitute a putative early stage in the visual information processing. Apart from the "spike-generating" regions (the classical receptive fields, CRFs), the receptive fields of threequarters of area 18 neurons contain silent, extraclassical suppressive regions (ECRFs). The spatial extent of summation areas of excitatory responses was negatively correlated with the strength of the ECRFinduced suppression of spike responses. Lowering the stimulus contrast resulted in an expansion of the summation areas of excitatory responses accompanied by a reduction in the strength of the ECRFinduced suppression. The spatial and temporal frequency and orientation tunings of the ECRFs were much broader than those of the CRFs. Hence, the ECRFs of area 18 neurons appear to be largely "inherited" from their dorsal thalamic inputs. In most area 18 cells, costimulation of CRFs and ECRFs resulted in significant increases in F1/F0 spike-response ratios, and thus there was a contextually modulated functional continuum between the simple and complex cells. luminance-modulated gratings; simple and complex cells; spatial and temporal properties; classical and extraclassical receptive fields; primary visual cortex HUBEL AND WIESEL (1965) postulated that in the domestic cat, the so-called parastriate cortex (cytoarchitectonic area 18 of Gurewitsch and Chatschaturian 1928; cf. Otsuka and Hässler 1962) constitutes a "higher order" visual cortical area (Fig.

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Section: Methodsmentioning

confidence: 99%

Phase sensitivities, excitatory summation fields, and silent suppressive receptive fields of single neurons in the parastriate cortex of the cat

Romo

Wang

Zeater

et al. 2011

Journal of Neurophysiology

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“…(C) The location of receptive field (RF) centers of 28 area 19 neurons tested for the effects of cooling of PTV. Note the location of RF centers of 11 area 17 neurons examined for velocity-tuning in the previous series of experiments (Huang et al, 2007). (D) Outlines of RFs of area 19 neurons of two cats included in the present study.…”

Section: Introductionmentioning

confidence: 99%

“…PTV constitutes a distinct part of pattern/form information processing stream (Campbell, 1978; Lomber et al, 1996a, b) and is the presumed homolog of primate infero-temporal cortex (Payne, 1993). Although PTV and primary visual cortices are interconnected only indirectly (Figure 1B, Rosenquist, 1985; Dreher, 1986; Dreher et al, 1996; Burke et al, 1998; Batardiere et al, 1998), reversible inactivation of PTV affects the responses and a number of receptive field (RF) characteristics, of a substantial proportion of neurons in the part of V1 corresponding visuotopically to PTV (Bardy et al, 2006, 2009; Huang et al, 2007). …”

Section: Introductionmentioning

confidence: 99%

Silencing “Top-Down” Cortical Signals Affects Spike-Responses of Neurons in Cat’s “Intermediate” Visual Cortex

Huang

Wang

Dreher

2017

Front. Neural Circuits

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We examined the effects of reversible inactivation of a higher-order, pattern/form-processing, postero-temporal visual (PTV) cortex on the background activities and spike-responses of single neurons in the ipsilateral cytoarchitectonic area 19 (putative area V3) of anesthetized domestic cats. Very occasionally (2/28), silencing recurrent “feedback” signals from PTV, resulted in significant and reversible reduction in background activity of area 19 neurons. By contrast, in large proportions of area 19 neurons, PTV inactivation resulted in: (i) significant reversible changes in the peak magnitude of their responses to visual stimuli (35.5%; 10/28); (ii) substantial reversible changes in direction selectivity indices (DSIs; 43%; 12/28); and (iii) reversible, upward shifts in preferred stimulus velocities (37%; 7/19). Substantial (≥20°) shifts in preferred orientation and/or substantial (≥20°) changes in width of orientation-tuning curves of area 19 neurons were however less common (26.5%; 4/15). In a series of experiments conducted earlier, inactivation of PTV also induced upward shifts in the preferred velocities of the ipsilateral cytoarchitectonic area 17 (V1) neurons responding optimally at low velocities. These upward shifts in preferred velocities of areas 19 and 17 neurons were often accompanied by substantial increases in DSIs. Thus, in both the primary visual cortex and the “intermediate” visual cortex (area 19), feedback from PTV plays a modulatory role in relation to stimulus velocity preferences and/or direction selectivity, that is, the properties which are usually believed to be determined by the inputs from the dorsal thalamus and/or feedforward inputs from the primary visual cortices. The apparent specialization of area 19 for processing information about stationary/slowly moving visual stimuli is at least partially determined, by the feedback from the higher-order pattern-processing visual area. Overall, the recurrent signals from the higher-order, pattern/form-processing visual cortex appear to play an important role in determining the magnitude of spike-responses and some “motion-related” receptive field properties of a substantial proportion of neurons in the intermediate form-processing visual area—area 19.

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“…Feedback is known to suppress noise and to enhance stimulus contrast (Hupé et al 1998;De Weerd et al 1999;Huang et al 2007;Hayes and Merigan 2007), in particular when the feedforward signal is weak (Supèr and Romeo 2011). Such an idea of noise reduction by feedback may explain why in our human study the false alarm rate remained constant and even slightly decreased for longer SOAs when the role of feedback is expected to be more pronounced.…”

Section: Model Versus Human Performancementioning

confidence: 57%

Stimulus detection after interruption of the feedforward response in a backward masking paradigm

et al. 2012

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In backward masking, a target stimulus is rendered invisible by the presentation of a second stimulus, the mask. When the mask is effective, neural responses to the target are suppressed. Nevertheless, weak target responses sometimes may produce a behavioural response. It remains unclear whether the reduced target response is a purely feedforward response or that it includes recurrent activity. Using a feedforward neural network of biological plausible spiking neurons, we tested whether a transient spike burst is sufficient for face categorization. After training the network, the system achieved face/non-face categorization for sets of grayscale images. In a backward masking paradigm, the transient burst response was cut off thereby reducing the feedforward target response. Despite the suppressed feedforward responses stimulus classification remained robust. Thus according to our model data stimulus detection is possible with purely, suppressed feedforward responses.

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The effects of reversible inactivation of postero-temporal visual cortex on neuronal activities in cat's area 17

Cited by 30 publications

References 80 publications

Phase sensitivities, excitatory summation fields, and silent suppressive receptive fields of single neurons in the parastriate cortex of the cat

Phase sensitivities, excitatory summation fields, and silent suppressive receptive fields of single neurons in the parastriate cortex of the cat

Silencing “Top-Down” Cortical Signals Affects Spike-Responses of Neurons in Cat’s “Intermediate” Visual Cortex

Stimulus detection after interruption of the feedforward response in a backward masking paradigm

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