The Effects of Reserpine on the Spontaneous Contraction of the Isolated Atrium of Rabbit Treated With Monoamine Oxidase Inhibitors

Tachi, Shunji; Nakatani, George; Fujiwara, Motohatsu

doi:10.1254/jjp.13.74

Cited by 3 publications

(2 citation statements)

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“…Chessin et al (9) have reported that mice, rats, guinea-pigs and rabbits pretreated with iproniazid respond to the administration of reserpine with marked motor excitation instead of the usual depression and that the blood pressure of the anesthetized cats pretreated with iproniazid is elevated by the administration of reserpine. The similar reversal of the action of reserpine has been shown in the isolated atrium of rabbit pretreated with iproniazid (10), and in the blood pressure of dog pretreated with SKFHowever, Nakanishi (1) has reported that the depressor responses of the anesthe tized rabbit, cat and dog to xylopinine were rather somewhat potentiated by SKF-385.…”

Section: Discussionsupporting

confidence: 56%

The Central Effects of Xylopinine in Mice

Yamamoto

1963

Japanese Journal of Pharmacology

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The depression of the spontaneous movement of mice by xylopinine, 2,3,10,11-tetra methoxy-5,6-13a-tetrahydro-8-dibenzo(a-g)quinolizinc, has been reported by Nakanishi (1). In the unanesthetized rabbit, the intravenous injection of xylopinine produced high voltage slow waves and increased spindle waves in EEG. The threshold voltage for eliciting the reticular arousal response by stimulation of the ascending reticular formation was also elevated.Recently, Hsu and Kin (2) have studied the pharmacological effects of tetrahydro palmatine and its analogues. They showed that tetrahydropalmatine exerted sedative tranquilizing effects in mice.The present experiments were designed to study sedative-tranquilizing effects of xylopinine in mice. METHODSThe experiments were performed in the mice, weighing 14 to 18 g, of both sexes.The drugs used in this experiment were all injected intraperitoneally in 0.2 ml of aqueous solution per 10 g. The drugs used were xylopinine citrate, tetrabenazine hy drochloride, chlorpromazine hydrochloride, methamphetamine hydrochloride, trans-dl 2-phenylcyclopropylamine maleate (SKF-385), caffeine and amobarbital sodium. Because of less solubility in water SKF-385 was suspended in the physiological saline solution.The locomotor movement of mice was measured as a number of rotations of the rotation apparatus devised by Takagi et al. (3). The sleeping time of mice was deter mined by measuring the period of time of the disappearance of the righting reflex over 20 seconds and was expressed in minutes. The antagonistic effects of xylopinine were assayed on the lethality in mice due to seizures produced by the injection of the convulsive drugs and by the electroshock. For the induction of the electroshock seizure the apparatus of Woodbury and Davenport (4) was used. Further details of the ex perimental methods will be described under the RESULTS. RESULTSI. Effects of vylopinine on the motor movement of the unanesthetized mice When the mice were transferred from the feeding cage to the rotation apparatus in the daytime, the animals showed the exploratory movements for a while, and some

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Section: Discussionsupporting

confidence: 56%

The Central Effects of Xylopinine in Mice

Yamamoto

1963

Japanese Journal of Pharmacology

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“…Tachi, Nakatani and Fujiwara (12) have studied the effects of reserpine on the isolated atrial preparation of rabbit pretreated with the MAO inhibitors. The atrium of rabbit pretreated with beta-phenylisopropylamine or SKF-385, either of which alone produces the positive inotropic and 'chronotropic effects, has responded to reserpine with the depressor effect, while the atrium of rabbit pretreated with iproniazid has responded to reserpine with the augmenting effect.…”

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Effects of SKF-385 and Reserpine on the Tissue Catecholamine Content in Rabbits

Shimamoto

Matsuo

Hattori

et al. 1964

Japanese Journal of Pharmacology

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The intravenous injection of 0.5 to 3.0 mg/kg of traps-2-phenylcyclopropylamine maleate in the anesthetized dog produces the pressor effect which is prevented by the adrenolytic doses of tolazoline and dibenamine (1). However, the repetition of the doses of SKF-385 exerts the depressor effect which is totally abolished by the pretreat ment with reserpine. The results indicate that the pressor effect relates with the release of the endogenous noradrenaline, while the depressor effect relates with the presence of the endogenous noradrenaline in the circulatory organs. The accumulation of the endogenous catecholamine after administration of monoamine oxidase (MAO) inhibitor has been shown in the central nervous system (2-4) and in the heart (5-7). On the other hand, the administration of iproniazid has been reported to produce no significant change of the brain noradrenaline in rabbit (8, 9) and of the heart noradrenaline in rabbit and mouse (9, 10). Goldberg and Shideman (11) have shown that the myo cardial noradrenaline in cat decreases significantly in response to 2 to 30 mg/kg of SKF 385, while that in rat increases markedly.Tachi, Nakatani and Fujiwara (12) have studied the effects of reserpine on the isolated atrial preparation of rabbit pretreated with the MAO inhibitors. The atrium of rabbit pretreated with beta-phenylisopropylamine or SKF-385, either of which alone produces the positive inotropic and 'chronotropic effects, has responded to reserpine with the depressor effect, while the atrium of rabbit pretreated with iproniazid has responded to reserpine with the augmenting effect. The results prompted to study the changes of catecholamine in the tissues including brain, heart, spleen and adrenal glands in the rabbit which received SKF-385 alone or reserpine after the pretreatment with SKF-385. METHODSAlbino rabbits, weighing 1.5 to 2.5 kg and of both sexes, were used in the present experiments. The drugs used were trans-2-phenylcyclopropylamine maleate (SKF-385) and reserpine. The drugs were injected into the marginal vein of theear. At 2, 4, 6, 8, 16, 24 and 32 hours after the injection of 5.0 mg/kg of SKF-385 the animals were sacrificed through bleeding by cutting both common carotid arteries.In another series of experiments, reserpine in the dose of 1.0 mg/kg was injected intravenously, at 0, 2, 4, 6, 14, 24 and 30 hours after the administration of 5.0 mg/kg of SKF-385. Two hours thereafter, the animals were killed and the brain cortex, brain stem, atria, spleen and adrenal glands were extirpated and weighed for the determina tion of catecholamine in the tissues. The tissues were homogenized by adding 0.4 N HC1O,. The homogenates of the tissues were prepared for the chemical assay of ad renaline and noradrenaline according to the method described by Higuchi (13). The content of noradrenaline in the brain cortex, brain stem and atria is expressed as /ag; g wet tissue weight, while that of noradrenaline or adrenaline in the spleen and adrenal glands is expressed as total ,ug.The contents of adrenaline ...

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Addenda to Volume I

1967

Psychopharmacological Agents

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The Effects of Reserpine on the Spontaneous Contraction of the Isolated Atrium of Rabbit Treated With Monoamine Oxidase Inhibitors

Cited by 3 publications

References 6 publications

The Central Effects of Xylopinine in Mice

The Central Effects of Xylopinine in Mice

Effects of SKF-385 and Reserpine on the Tissue Catecholamine Content in Rabbits

Addenda to Volume I

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