The effects of repetitive transcranial magnetic stimulation on eating behaviors and body weight in obesity: A randomized controlled study

Kim, Se‐Hong; Chung, Jin-Woong; Kim, Tae-Hong; Lim, Seong Hoon; Kim, Youngkook; Lee, Yun-Ah; Song, Sang‐Wook

doi:10.1016/j.brs.2017.11.020

Cited by 38 publications

(34 citation statements)

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“…Actual food consumption also mirrors the above effects, with experimental studies largely showing moderate-sized effects on appetitive food consumption following dlPFC modulation. 156 Several multisession intervention trials have likewise shown promising effects of repeated administration of dlPFC modulation on weight and eating outcomes [165][166][167] although the feasibility of such treatments for population-level problems such as overweight and obesity is not fully clear (along these lines, exercise may be a superior populationlevel strategy, not only because of its effects on metabolism, but also its effect on brain health 168 ).…”

Section: The Social Neurobiology Of Food Consumptionmentioning

confidence: 99%

Neuroimaging, neuromodulation, and population health: the neuroscience of chronic disease prevention

Hall

Bickel

Erickson

et al. 2018

Annals of the New York Academy of Sciences

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Preventable chronic diseases are the leading cause of death in the majority of countries throughout the world, and this trend will continue for the foreseeable future. The potential to offset the social, economic, and personal burdens associated with such conditions depends on our ability to influence people's thought processes, decisions, and behaviors, all of which can be understood with reference to the brain itself. Within the health neuroscience framework, the brain can be viewed as a predictor, mediator, moderator, or outcome in relation to health‐related phenomena. This review explores examples of each of these, with specific reference to the primary prevention (i.e., prevention of initial onset) of chronic diseases. Within the topic of primary prevention, we touch on several cross‐cutting themes (persuasive communications, delay discounting of rewards, and self‐control), and place a special focus on obesity as a disorder influenced by both eating behavior and exercise habits.

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Section: The Social Neurobiology Of Food Consumptionmentioning

confidence: 99%

Neuroimaging, neuromodulation, and population health: the neuroscience of chronic disease prevention

Hall

Bickel

Erickson

et al. 2018

Annals of the New York Academy of Sciences

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“… Kim et al (2018) were the first to show that 10Hz rTMS delivered to the left DLPFC in a mixed-gender, obese sample even reduced food consumption and hence body weight in obese individuals. They, however, applied not just one but four rTMS sessions also leading to higher levels of satiety than in the sham group.…”

Section: Resultsmentioning

confidence: 92%

“…Contrarily, C-reactive protein and lipid profiles remained almost unaffected probably due to the relatively short duration of the study. Together, these findings suggest that multiple rTMS sessions, like multiple tDCS sessions, have the potential to reduce body weight and may even decrease the risk for vascular events ( Kim et al, 2018 ). Applying just a single 10Hz rTMS session seems less effective.…”

Section: Resultsmentioning

confidence: 96%

“…RTMS ( Uher et al, 2005 ; Barth et al, 2011 ) or tDCS ( Goldman et al, 2011 ; Montenegro et al, 2012 ; Kekic et al, 2014 ; Lapenta et al, 2014 ) delivered in a single session to the DLPFC, appear effective to reduce food craving rather than calorie consumption (see Supplementary Table S1 ). Reduced food consumption ( Kim et al, 2018 ), mainly of high-caloric food ( Jauch-Chara et al, 2014 ), as well as sustained reductions in food craving ( Ljubisavljevic et al, 2016 ) were achieved with multiple DLPFC stimulation sessions. TDCS was also tested in combination with standard weight-loss approaches such as aerobic exercise.…”

Section: Discussionmentioning

confidence: 99%

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Invasive and Non-invasive Stimulation of the Obese Human Brain

Pleger

2018

Front. Neurosci.

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Accumulating evidence suggests that non-invasive and invasive brain stimulation may reduce food craving and calorie consumption rendering these techniques potential treatment options for obesity. Non-invasive transcranial direct current stimulation (tDCS) or repetitive transcranial magnet stimulation (rTMS) are used to modulate activity in superficially located executive control regions, such as the dorsolateral prefrontal cortex (DLPFC). Modulation of the DLPFC’s activity may alter executive functioning and food reward processing in interconnected dopamine-rich regions such as the striatum or orbitofrontal cortex. Modulation of reward processing can also be achieved by invasive deep brain stimulation (DBS) targeting the nucleus accumbens. Another target for DBS is the lateral hypothalamic area potentially leading to improved energy expenditure. To date, available evidence is, however, restricted to few exceptional cases of morbid obesity. The vagal nerve plays a crucial role in signaling the homeostatic demand to the brain. Invasive or non-invasive vagal nerve stimulation (VNS) is thus assumed to reduce appetite, rendering VNS another possible treatment option for obesity. Based on currently available evidence, the U.S. Food and Drug Administration recently approved VNS for the treatment of obesity. This review summarizes scientific evidence regarding these techniques’ efficacy in modulating food craving and calorie intake. It is time for large controlled clinical trials that are necessary to translate currently available research discoveries into patient care.

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“…Modulation of the left dlPFC reliably alters response to appetitive, calorie-dense food items [1,2]. Such effects are more reliable with rTMS than tDCS, and when stimulation is leftsided than right-sided [1,3,4] see also [5]. The involvement of the dlPFC in dietary self-control and the propensity toward weight gain is corroborated by functional imaging studies that also implicate the dlPFC in dietary self-control and obesity [6].…”

Section: Introductionmentioning

confidence: 85%

Contextual cues as modifiers of cTBS effects on indulgent eating

Safati

Hall

2019

Preprint

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Background: Prior studies have found that continuous theta burst stimulation (cTBS) targeting the left dlPFC results in reliable increases in consumption of calorie-dense food items. However, it is not known to what extent such effects are modified by cues in the immediate eating environment. Tempting environments (i.e., those saturated with appetitive eating cues) may lead to more reliance on cognitive control networks involving the dlPFC, thereby enhancing cTBS on eating.Objective/Hypothesis: The objective was to examine the extent to which cTBS effects on eating would be modified by contextual cues. It was hypothesized that cTBS effects on eating would be stronger in the presence of facilitating cues.Methods: Using a between-subjects factorial design, 107 adults were randomly assigned to one of four conditions: 1) active cTBS + facilitating cues, 2) sham cTBS + facilitating cues, 3) active cTBS + inhibiting cues, 4) sham cTBS + inhibiting cues. Following stimulation participants completed a flanker paradigm and a taste test during which quantity consumed was assessed surreptitiously.Results: Findings revealed a significant interaction between stimulation and cue type (F(1,102)=6.235, p=.014), such that the effects of cTBS were stronger for those in the facilitating cue condition. Conclusions:The effects of cTBS on eating are strengthened in the presence of facilitating cues.Methodologically speaking, facilitating cues may be a functional prerequisite for exploring cTBS effects on eating in the laboratory. Substantively, the findings also suggest that facilitating cues Indulgent Eating 3 in the eating environment may amplify counter-intentional food indulgence in everyday life via cognitive control failure.

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The effects of repetitive transcranial magnetic stimulation on eating behaviors and body weight in obesity: A randomized controlled study

Cited by 38 publications

References 38 publications

Neuroimaging, neuromodulation, and population health: the neuroscience of chronic disease prevention

Neuroimaging, neuromodulation, and population health: the neuroscience of chronic disease prevention

Invasive and Non-invasive Stimulation of the Obese Human Brain

Contextual cues as modifiers of cTBS effects on indulgent eating

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