The effects of repeated administration of diazepam, MK-801 and CGP 37849 on rat behavior in two models of anxiety

Jessa, Maria; Nazar, Maciej; Bidziński, Andrzej; Płaźnik, Adam

doi:10.1016/0924-977x(95)00068-z

Cited by 46 publications

(15 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…On the other hand, the lack of anxiogenic-like activity of this compound in the VT can be explained by a "floor effect", when potent suppression of water intake by an aversive stimulus makes its deeper inhibition unlikely. It is noteworthy that different BDZ receptor ligands were shown previously not to change significantly spontaneous water intake and pain sensitivity in rats, at least at anxiolytic doses (Pta~nik et al, 1994;Jessa et al, 1996). Considering the aforementioned facts, it may be suggested that the absence of any effects in the OFT of the BDZ partial agonist, bretazenil, is due to its lower potency at the BDZ receptor.…”

Section: Discussionmentioning

confidence: 89%

“…The OFT and VT have been well established as standard procedures sensitive to the anxiolytic-like effects of drugs (Pollard et al, 1990). In previous studies performed in our laboratory these two tests were found to be sensitive to the anxiolytic-like action of numerous compounds acting via a variety of neurotransmitter and receptor pathways (Stefafiski et al, 1992;P~a~nik et al, 1994;Jessa et al, 1996). Anxiolytic-like actions of 5-HTIA agonists, 5-HT3 antagonists and NMDA receptor complex antagonists, was shown in the OFT and VT tests.…”

Section: Discussionmentioning

confidence: 98%

See 1 more Smart Citation

Benzodiazepine-GABAA receptor complex ligands in two models of anxiety

Nazar

Jessa

Płaźnik

1997

J. Neural Transmission

View full text Add to dashboard Cite

In the present study, the actions of several compounds with different intrinsic activities and BDZ receptor selectivity were examined in two well established animal models of anxiety: the open field test (OFT) and Vogel's punished drinking text (VT). Full agonists at the BDZ GABAA receptor (midazolam and diazepam) showed anxiolytic-like effects in both tests; however, the doses necessary to disinhibit animal behavior controlled by fear were higher in the VT than in the OFT. None of the partial BDZ receptor agonists studied (bretazenil, Ro 19-8022 and abecarnil) diminished neophobia-like behavior of rats in the OFT, and their sedative influence on gross behavior prevailed. On the other hand, all three drugs produced a clear-cut anxiolytic effect in the VT. A selective BDZ, receptor subtype full agonist (zolpidem) had a similar profile of action to that of partial agonists with an even stronger sedative effect in the OFT. Alpidem (a selective BDZ1 receptor partial agonist) did not reveal any anxiolytic action in either test. Flumazenil (an antagonist at the BDZ-GABAA receptors) also produced no effect in the OFT, or the VT. An inverse BDZ receptor agonist, beta-carboline-3-carboxylate methyl ester (beta-CCM), evoked an anxiogenic-like response in the OFT, but not in the VT. In summary, it appeared that partial agonists and selective ligands at BDZ1 receptors revealed less advantageous anxiolytic-like action than did full allosteric GABAA receptor modulators. This study also indicates the test dependent profiles of action of BDZ-GABAA receptor ligands. It also indirectly suggests a different neurobiological background underlying the applied tests.

show abstract

Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 98%

Benzodiazepine-GABAA receptor complex ligands in two models of anxiety

Nazar

Jessa

Płaźnik

1997

J. Neural Transmission

View full text Add to dashboard Cite

show abstract

“…The effects of NMDA receptor ligands on seizure activity have been well characterized [Carter et al, 1995;Hoffman et al, 1992;Kotlinska and Liljequist, 1996;Valverius et al, 1990]; however, much less is known about their contribution to anxiety. Antagonists at the competitive site as well as the various allosteric modulatory sites on the NMDA receptor have been found to be anxiolytic in both mice and rats in a number of assays [Dunn et al, 1992;Jessa et al, 1996;Kotlinska and Liljequist, 1998;Wiley et al, 1995]. These compounds also block PTZ-induced anxiety in the EPM [De Souza et al, 1998;Matheus and Guimaraes, 1997], and NMDA (0-40 mg/kg, s.c.) partially substitutes for PTZ in rats trained to discriminate PTZ from saline (Table 1).…”

Section: N-methyl-d-aspartate Glutamate Receptorsmentioning

confidence: 94%

Animal models of the anxiogenic effects of ethanol withdrawal

Gatch¹,

Lal²

2001

Drug Development Research

View full text Add to dashboard Cite

Although anxiety is a major feature of ethanol withdrawal (EW) and much of treatment related to EW is focused on amelioration of the anxiety experienced during EW, less attention has been given to the anxiogenic effects of EW than to the convulsant effects. In this article, we review the animal literature on the anxiogenic effects of EW. Both GABA A and serotonin (5-HT) receptors are important targets in the treatment of anxiety. The roles of each of these two receptors on the anxiogenic effects of EW as well as their potential interrelation are discussed. The contribution of other receptor systems to the modulation of these effects is reviewed. Additionally, males and females show very different levels of anxiety during EW and studies on the role of the HPA axis in mediating these effects are examined. Finally, potential directions for better treatments for EW are discussed. Drug Dev. Res. 54:95-115, 2001.

show abstract

“…This suggests a commonality of effects between EtOH and NMDA antagonists. Interestingly, the latter compounds have been shown to exert anxiolytic effects in a variety of tests (Martinez et al, 2002;Molina-Hernández et al, 2006;Jessa et al, 1996). Therefore, it could be argued that early anxiolytic effects of EtOH act in the devaluation paradigm through NMDA mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Differential effects of ethanol and midazolam upon the devaluation of an aversive memory in infant rats

Pautassi

Nizhnikov

Molina

et al. 2007

Alcohol

View full text Add to dashboard Cite

In infant rats, low doses of ethanol have been found to attenuate the aversive representation of an unconditioned stimulus (US) as assessed through a revaluation paradigm. This may be explained by early anxiolytic properties of EtOH. The present set of experiments was aimed at analyzing possible mechanisms of these putative anti-anxiety effects of EtOH. In a the first experiment, EtOH's effects upon the expression of citric acid-induced distress calls were compared with varying doses of midazolam (MDZ), a fast-acting GABA A agonist. Similar calming effects of 0.5 g/kg EtOH and 0.09 mg/kg MDZ were observed. Both drugs were then assessed in their capability to alter the expression of a conditioned aversion by devaluing the US. Aversive conditioning was conducted on postnatal day 14 (PD14) by pairing a lemon odor (conditioned stimulus, CS) with intraoral stimulation of citric acid (US). Control animals experienced both stimuli in an explicitly unrelated fashion. On PD 15 pups were briefly exposed to the citric acid solution under the effects of 0.5 g/kg EtOH, 0.09 mg/kg MDZ, or the respective vehicle for each drug. Pups were then tested in a two-way odor preference test (lemon vs. cineole). Both vehicle and MDZ-treated animals spent significantly less time near the lemon CS, thus expressing a citric-acid mediated odor aversion. This conditioned response was completely inhibited in pups that received 0.5 g/kg EtOH. Locomotor patterns at test were not affected by either EtOH or MDZ administration. A higher dose of MDZ (0.18 mg/kg, i.p) was also ineffective in attenuating the aversive memory. In summary, EtOH's devaluating capabilities are not shared by MDZ, indicating that these effects of EtOH may not be GABA-mediated. Appetitive motivational properties of EtOH or non-GABA A -mediated anti-anxiety effects (i.e, NMDA-related) could underlie this devaluation effect of ethanol.

show abstract

The effects of repeated administration of diazepam, MK-801 and CGP 37849 on rat behavior in two models of anxiety

Cited by 46 publications

References 25 publications

Benzodiazepine-GABAA receptor complex ligands in two models of anxiety

Benzodiazepine-GABAA receptor complex ligands in two models of anxiety

Animal models of the anxiogenic effects of ethanol withdrawal

Differential effects of ethanol and midazolam upon the devaluation of an aversive memory in infant rats

Contact Info

Product

Resources

About